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Kim K, Doi A, Wen B, Ng K, Zhao R, Cahan P, Kim J, Aryee MJ, Ji H, Ehrlich LI, Yabuuchi A, Takeuchi A, Cunniff KC, Hongguang H, McKinney-Freeman S, Naveiras O, Yoon TJ, Irizarry RA, Jung N, Seita J, Hanna J, Murakami P, Jaenisch R, Weissleder R, Orkin SH, Weissman IL, Feinberg AP, Daley GQ
Epigenetic memory in induced pluripotent stem cells.
Nature. 2010;467(7313):285-90 - PMID: 20644535 - PMCID: PMC3150836
Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, Clish CB, Vaitheesvaran B, Iliopoulos O, Kurland I, Dor Y, Weissleder R, Shirihai OS, Ellisen LW, Espinosa JM, Mostoslavsky R
The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1alpha.
Cell. 2010;140(2):280-293 - PMID: 20141841 - PMCID: PMC2821045
Haun JB, Devaraj NK, Hilderbrand SA, Lee H, Weissleder R
Bioorthogonal chemistry amplifies nanoparticle binding and enhances the sensitivity of cell detection
Nat Nanotechnol. 2010;5(9):660-5 - PMID: 20676091 - PMCID: PMC2934903
Swirski FK, Wildgruber M, Ueno T, Figueiredo JL, Panizzi P, Iwamoto Y, Zhang E, Stone JR, Rodriguez E, Chen JW, Pittet MJ, Weissleder R, Nahrendorf M
Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice.
J Clin Invest. 2010;120(7):2627-34 - PMID: 20577051 - PMCID: PMC2898607
Gaglia JL, Guimaraes AR, Harisinghani M, Turvey SE, Jackson R, Benoist C, Mathis D, Weissleder R
Noninvasive imaging of pancreatic islet inflammation in type 1A diabetes patients.
J Clin Invest. 2010;121(1):442-5 - PMID: 21123946 - PMCID: PMC3007157
Condeelis J, Weissleder R
In Vivo Imaging in Cancer.
Cold Spring Harb Perspect Biol. 2010;2(12):a003848 - PMID: 20861158 - PMCID: PMC2982169 - Cover
Morishige K, Kacher DF, Libby P, Josephson L, Ganz P, Weissleder R, Aikawa M
High-Resolution Magnetic Resonance Imaging Enhanced With Superparamagnetic Nanoparticles Measures Macrophage Burden in Atherosclerosis.
Circulation. 2010;122(17):1707-15 - PMID: 20937980 - PMCID: PMC3003265
Nahrendorf M, Pittet MJ, Swirski FK
Monocytes: protagonists of infarct inflammation and repair after myocardial infarction.
Circulation. 2010;121(22):2437-45 - PMID: 20530020 - PMCID: PMC2892474
Sakhuja R, Suh WM, Jaffer FA, Jang IK
Residual Thrombogenic Substrate After Rupture of a Lipid-Rich Plaque: Possible Mechanism of Acute Stent Thrombosis?
Circulation. 2010;122(22):2349-2350 - PMID: 21147731
Parekkadan B, Upadhyay R, Dunham J, Iwamoto Y, Mizoguchi E, Mizoguchi A, Weissleder R, Yarmush ML
Bone Marrow Stromal Cell Transplants Prevent Experimental Enterocolitis and Require Host CD11b+ Splenocytes.
Gastroenterology. 2010;140(3):966-975.e4 - PMID: 20955701 - PMCID: PMC3033974
Panizzi P, Swirski FK, Figueiredo JL, Waterman P, Sosnovik DE, Aikawa E, Libby P, Pittet M, Weissleder R, Nahrendorf M
Impaired infarct healing in atherosclerotic mice with Ly-6C(hi) monocytosis.
J Am Coll Cardiol. 2010;55(15):1629-38 - PMID: 20378083 - PMCID: PMC2852892
Gros J, Hu JK, Vinegoni C, Feruglio PF, Weissleder R, Tabin CJ
WNT5A/JNK and FGF/MAPK Pathways Regulate the Cellular Events Shaping the Vertebrate Limb Bud.
Curr Biol. 2010;20(22):1993-2002 - PMID: 21055947 - PMCID: PMC2998074
Leuschner F, Panizzi P, Chico-Calero I, Lee WW, Ueno T, Cortez-Retamozo V, Waterman P, Gorbatov R, Marinelli B, Iwamoto Y, Chudnovskiy A, Figueiredo JL, Sosnovik DE, Pittet MJ, Swirski FK, Weissleder R, Nahrendorf M
Angiotensin-Converting Enzyme Inhibition Prevents the Release of Monocytes From Their Splenic Reservoir in Mice With Myocardial Infarction.
Circ Res. 2010;107(11):1364-73 - PMID: 20930148 - PMCID: PMC2992104
Hjortnaes J, Butcher J, Figueiredo JL, Riccio M, Kohler RH, Kozloff KM, Weissleder R, Aikawa E
Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation.
Eur Heart J. 2010;31(16):1975-84 - PMID: 20601388 - PMCID: PMC2921509
Nahrendorf M, Keliher E, Marinelli B, Waterman P, Feruglio PF, Fexon L, Pivovarov M, Swirski FK, Pittet MJ, Vinegoni C, Weissleder R
Hybrid PET-optical imaging using targeted probes
Proc Natl Acad Sci U S A. 2010;107(17):7910-5 - PMID: 20385821 - PMCID: PMC2867879
Hung KE, Maricevich MA, Richard LG, Chen WY, Richardson MP, Kunin A, Bronson RT, Mahmood U, Kucherlapati R
Development of a mouse model for sporadic and metastatic colon tumors and its use in assessing drug treatment.
Proc Natl Acad Sci U S A. 2010;107(4):1565-70 - PMID: 20080688 - PMCID: PMC2824379
Vallet S, Mukherjee S, Vaghela N, Hideshima T, Fulciniti M, Pozzi S, Santo L, Cirstea D, Patel K, Sohani AR, Guimaraes A, Xie W, Chauhan D, Schoonmaker JA, Attar E, Churchill M, Weller E, Munshi N, Seehra JS, Weissleder R, Anderson KC, Scadden DT, Raje N
Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone disease.
Proc Natl Acad Sci U S A. 2010;107(11):5124-9 - PMID: 20194748 - PMCID: PMC2841922
McCarthy JR
Multifunctional agents for concurrent imaging and therapy in cardiovascular disease.
Adv Drug Deliv Rev. 2010;62(11):1023-30 - PMID: 20654664 - PMCID: PMC2974776
Taniguchi CM, Winnay J, Kondo T, Bronson RT, Guimaraes AR, Aleman JO, Luo J, Stephanopoulos G, Weissleder R, Cantley LC, Kahn CR
The Phosphoinositide 3-Kinase Regulatory Subunit p85{alpha} Can Exert Tumor Suppressor Properties through Negative Regulation of Growth Factor Signaling.
Cancer Res. 2010;70(13):5305-5315 - PMID: 20530665 - PMCID: PMC3204358
Yoo BK, Chen D, Su ZZ, Gredler R, Yoo J, Shah K, Fisher PB, Sarkar D
Molecular Mechanism of Chemoresistance by Astrocyte Elevated Gene-1.
Cancer Res. 2010;70(8):3249-58 - PMID: 20388796 - PMCID: PMC2855753
Bagci-Onder T, Wakimoto H, Anderegg M, Cameron C, Shah K
A dual PI3K/mTOR inhibitor, PI-103, cooperates with stem cell delivered TRAIL in experimental glioma models.
Cancer Res. 2010;71(1):154-63 - PMID: 21084267
Liong M, Shao H, Haun JB, Lee H, Weissleder R
Carboxymethylated Polyvinyl Alcohol Stabilizes Doped Ferrofluids for Biological Applications.
Adv Mater. 2010;22(45):5168-72 - PMID: 20859943 - PMCID: PMC2993874
Rodriguez E, Nilges M, Weissleder R, Chen JW
Activatable magnetic resonance imaging agents for myeloperoxidase sensing: mechanism of activation, stability, and toxicity.
J Am Chem Soc. 2010;132(1):168-77 - PMID: 19968300 - PMCID: PMC2802665
Hingtgen SD, Kasmieh R, van de Water J, Weissleder R, Shah K
Determining Multiple Aspects of Stem Cell-Based Therapies Using Novel Diagnostic and Therapeutic Multifunctional Molecules.
Stem Cells. 2010;28(4):832-41 - PMID: 20127797 - PMCID: PMC3021283
van Eekelen M, Sasportas LS, Kasmieh R, Yip S, Figueiredo JL, Louis DN, Weissleder R, Shah K
Human stem cells expressing novel TSP-1 variant have anti-angiogenic effect on brain tumors.
Oncogene. 2010;29(22):3185-95 - PMID: 20305695 - PMCID: PMC3390229
Chang K, Francis SA, Aikawa E, Figueiredo JL, Kohler RH, McCarthy JR, Weissleder R, Plutzky J, Jaffer FA
Pioglitazone Suppresses Inflammation In Vivo in Murine Carotid Atherosclerosis. Novel Detection by Dual-Target Fluorescence Molecular Imaging.
Arterioscler Thromb Vasc Biol. 2010;30(10):1933-9 - PMID: 20689078 - PMCID: PMC3030475
Kramer CM, Sinusas AJ, Sosnovik DE, French BA, Bengel FM
Multimodality Imaging of Myocardial Injury and Remodeling.
J Nucl Med. 2010;51 Suppl 1:107S-121S - PMID: 20395347 - PMCID: PMC3078824
Kraehenbuehl TP, Ferreira LS, Hayward AM, Nahrendorf M, van der Vlies AJ, Vasile E, Weissleder R, Langer R, Hubbell JA
Human embryonic stem cell-derived microvascular grafts for cardiac tissue preservation after myocardial infarction.
Biomaterials . 2010;32(4):1102-9 - PMID: 21035182
Jurewicz M, Ueno T, Azzi J, Tanaka K, Murayama T, Yang S, Sayegh MH, Niimi M, Abdi R
Donor Antioxidant Strategy Prolongs Cardiac Allograft Survival by Attenuating Tissue Dendritic Cell Immunogenicity.
Am J Transplant. 2010;11(2):348-355 - PMID: 21182586
McCarthy JR, Korngold E, Weissleder R, Jaffer FA
A Light-Activated Theranostic Nanoagent for Targeted Macrophage Ablation in Inflammatory Atherosclerosis.
Small. 2010;6(18):2041-9 - PMID: 20721949 - PMCID: PMC3018665
Gultepe E, Reynoso FJ, Jhaveri A, Kulkarni P, Nagesha D, Ferris C, Harisinghani M, Campbell RB, Sridhar S
Monitoring of magnetic targeting to tumor vasculature through MRI and biodistribution.
Nanomedicine (Lond). 2010;5(8):1173-82 - PMID: 21039195
Martinez-Boubeta C, Balcells L, Cristool R, Sanfeliu C, Rodriguez E, Weissleder R, Lope-Piedrafita S, Simeonidis K, Angelakeris M, Sandiumenge F, Calleja A, Casas L, Monty C, Martinez B
Self-assembled Multifunctional Fe/MgO Nanospheres for Magnetic Resonance Imaging and Hyperthermia.
Nanomed. 2010;6(2):362-370 - PMID: 19800988
Pandharipande PV, Gervais DA, Hartman RI, Harisinghani MG, Feldman AS, Mueller PR, Gazelle GS
Renal Mass Biopsy to Guide Treatment Decisions for Small Incidental Renal Tumors: A Cost-effectiveness Analysis.
Radiology. 2010;256(3):836-46 - PMID: 20720070 - PMCID: PMC2923731
Hamed HA, Yacoub A, Park MA, Eulitt PJ, Dash R, Sarkar D, Dmitriev IP, Lesniak MS, Shah K, Grant S, Curiel DT, Fisher PB, Dent P
Inhibition of Multiple Protective Signaling Pathways and Ad.5/3 Delivery Enhances mda-7/IL-24 Therapy of Malignant Glioma.
Mol Ther. 2010;18(6):1130-42 - PMID: 20179672 - PMCID: PMC2889737
Wiles KG, Panizzi P, Kroh HK, Bock PE
Skizzle is a novel plasminogen and plasmin binding protein from Streptococcus agalactiae that targets proteins of human fibrinolysis to promote plasmin generation.
J Biol Chem. 2010;285(27):21153-64 - PMID: 20435890 - PMCID: PMC2898333
Fourches D, Pu D, Tassa C, Weissleder R, Shaw SY, Mumper RJ, Tropsha A
Quantitative Nanostructure-Activity Relationship Modeling.
ACS Nano. 2010;4(10):5703-12 - PMID: 20857979 - PMCID: PMC2997621
Osborn EA, Jaffer FA
The year in molecular imaging.
JACC Cardiovasc Imaging. 2010;3(11):1181-95 - PMID: 21071007 - PMCID: PMC3057415
Emdad L, Sarkar D, Lee SG, Su ZZ, Yoo BK, Dash R, Yacoub A, Fuller CE, Shah K, Dent P, Bruce JN, Fisher PB
Astrocyte elevated gene-1: a novel target for human glioma therapy.
Mol Cancer Ther. 2010;9(1):79-88 - PMID: 20053777 - PMCID: PMC3165052
Kirsch DG, Grimm J, Guimaraes AR, Wojtkiewicz GR, Perez BA, Santiago PM, Anthony NK, Forbes T, Doppke K, Weissleder R, Jacks T
Imaging Primary Lung Cancers in Mice to Study Radiation Biology.
Int J Radiat Oncol Biol Phys. 2010;76(4):973-977 - PMID: 20206017 - PMCID: PMC2847457
Reiner T, Kohler RH, Liew CW, Hill JA, Gaglia J, Kulkarni RN, Weissleder R
Near-Infrared Fluorescent Probe for Imaging of Pancreatic B Cells
Bioconjug Chem. 2010;21:1362-1368 - PMID: 20583828 - PMCID: PMC2912453
Bratlie KM, Dang TT, Lyle S, Nahrendorf M, Weissleder R, Langer R, Anderson DG
Rapid biocompatibility analysis of materials via in vivo fluorescence imaging of mouse models.
PLoS ONE. 2010;5(4):e10032 - PMID: 20386609 - PMCID: PMC2850367
Berny MA, Munnix IC, Auger JM, Schols SE, Cosemans JM, Panizzi P, Bock PE, Watson SP, McCarty OJ, Heemskerk JW
Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear.
PLoS ONE. 2010;5(4):e10415 - PMID: 20454680 - PMCID: PMC2861630
Razansky RN, Rosenthal A, Mallas G, Razansky D, Jaffer FA, Ntziachristos V
Near-infrared fluorescence catheter system for two-dimensional intravascular imaging in vivo.
Optics Express. 2010;18(11):11372-81 - PMID: 20588998
Thurber GM, Weissleder R
Quantitating Antibody Uptake In Vivo: Conditional Dependence on Antigen Expression Levels.
Mol Imaging Biol. 2010;13(4):623-32 - PMID: 20809210 - PMCID: PMC3000888
Guimaraes AR, Ross R, Figuereido JL, Waterman P, Weissleder R
MRI with Magnetic Nanoparticles Monitors Downstream Anti-Angiogenic Effects of mTOR Inhibition.
Mol Imaging Biol. 2010;13(2):314-20 - PMID: 20559742
Reiner T, Earley S, Turetsky A, Weissleder R
Bioorthogonal Small-Molecule Ligands for PARP1 Imaging in Living Cells.
Chembiochem. 2010;11(17):2374-2377 - PMID: 20967817 - PMCID: PMC3034378
Calfon MA, Vinegoni C, Ntziachristos V, Jaffer FA
Intravascular near-infrared fluorescence molecular imaging of atherosclerosis: toward coronary arterial visualization of biologically high-risk plaques.
J Biomed Opt. 2010;15(1):011107 - PMID: 20210433 - PMCID: PMC3188610
Uppot RN, Harisinghani MG, Gervais DA
Imaging-guided percutaneous renal biopsy: rationale and approach.
AJR Am J Roentgenol. 2010;194(6):1443-9 - PMID: 20489082
Gee MS, Kim JY, Gervais DA, Hahn PF, Mueller PR
Management of abdominal and pelvic abscesses that persist despite satisfactory percutaneous drainage catheter placement.
AJR Am J Roentgenol. 2010;194(3):815-20 - PMID: 20173165
Cronin CG, Harisinghani MG, Catalano O, Blake MA
Multitechnique imaging findings of prolene plug hernia repair.
AJR Am J Roentgenol. 2010;195(3):701-6 - PMID: 20729449
Fumene Feruglio P, Vinegoni C, Gros J, Sbarbati A, Weissleder R
Block matching 3D random noise filtering for absorption optical projection tomography.
Phys Med Biol. 2010;55(18):5401-5415 - PMID: 20736500 - PMCID: PMC2934766
McCarthy JR, Bhaumik J, Karver MR, Sibel Erdem S, Weissleder R
Targeted nanoagents for the detection of cancers.
Mol Oncol. 2010;4(6):511-28 - PMID: 20851695 - PMCID: PMC2981649
Hamilton AM, Rogers KA, Belisle AJ, Ronald JA, Rutt BK, Weissleder R, Boughner DR
Early identification of aortic valve sclerosis using iron oxide enhanced MRI.
J Magn Reson Imaging. 2010;31(1):110-6 - PMID: 20027578
Figueiredo JL, Siegel C, Nahrendorf M, Weissleder R
Intraoperative Near-Infrared Fluorescent Cholangiography (NIRFC) in Mouse Models of Bile Duct Injury.
World J Surg. 2010;34 (2):336-343 - PMID: 20033407 - PMCID: PMC2809822
de la Rosette J, Ahmed H, Barentsz J, Johansen TB, Brausi M, Emberton M, Frauscher F, Greene D, Harisinghani M, Haustermans K, Heidenreich A, Kovacs G, Mason M, Montironi R, Mouraviev V, de Reijke T, Taneja S, Thuroff S, Tombal B, Trachtenberg J, Wijkstra H, Polascik T
Focal therapy in prostate cancer-report from a consensus panel.
J Endourol. 2010;24(5):775-80 - PMID: 20477543
Eisner BH, Kurtz MP, Harisinghani MG
Evolving Role of Magnetic Resonance Imaging in Renal Cancer Imaging.
J Endourol. 2010;24(5):707-11 - PMID: 20433369
Islam T, Harisinghani MG
Prostate cancer imaging: what the next decade holds.
Expert Rev Med Devices. 2010;7(5):577-9 - PMID: 20822379
Shenoy-Bhangle A, Nimkin K, Gee MS
Pediatric imaging: Current and emerging techniques.
J Postgrad Med. 2010;56(2):98-102 - PMID: 20622388
Sanghvi D, Harisinghani MG
Modalities in modern radiology: A synopsis.
J Postgrad Med. 2010;56(2):85-7 - PMID: 20622386
Shenoy-Bhangle A, Nimkin K, Gee MS
Pediatric imaging: Current and emerging techniques.
J Postgrad Med. 2010;56(2):98-102 - PMID: 20622388
Karaosmanoglu AD, Gee MS
Sonographic findings of an adrenal leiomyosarcoma.
J Ultrasound Med. 2010;29(9):1369-73 - PMID: 20733196
Libby P, Nahrendorf M, Weissleder R
Molecular imaging of atherosclerosis: a progress report.
Tex Heart Inst J. 2010;37(3):324-7 - PMID: 20548813 - PMCID: PMC2879214
Saokar A, Islam T, Jantsch M, Saksena MA, Hahn PF, Harisinghani MG
Detection of lymph nodes in pelvic malignancies with computed tomography and magnetic resonance imaging.
Clin Imaging. 2010;34(5):361-6 - PMID: 20813300
Saokar A, Gee MS, Islam T, Mueller PR, Harisinghani MG
Appearance of primary lymphoid malignancies on lymphotropic nanoparticle-enhanced magnetic resonance imaging using ferumoxtran-10.
Clin Imaging. 2010;34(6):448-52 - PMID: 21092874
Ventura E, Islam T, Gee MS, Mahmood U, Braschi M, Harisinghani MG
Detection of nodal metastatic disease in patients with non-small cell lung cancer: comparison of positron emission tomography (PET), contrast-enhanced computed tomography (CT), and combined PET-CT.
Clin Imaging. 2010;34(1):20-28 - PMID: 20122515
Lee DK, Nahrendorf M, Schellingerhout D, Kim DE
Will molecular optical imaging have clinically important roles in stroke management, and how?
J Clin Neurol. 2010;6(1):10-8 - PMID: 20386638 - PMCID: PMC2851295
McCarthy JR
Nanomedicine and Cardiovascular Disease.
Curr Cardiovasc Imaging Rep. 2010;3(1):42-49 - PMID: 20369034 - PMCID: PMC2848940
Shah K
In Vivo Imaging of the Dynamics of Different Variants of EGFR in Glioblastomas.
Methods Mol Biol. 2010;680:153-164 - PMID: 21153380
Jaffer FA
Intravital Fluorescence Microscopic Molecular Imaging of Atherosclerosis.
Methods Mol Biol. 2010;680:131-140 - PMID: 21153378 - PMCID: PMC3051165
Iyer VR, Hahn PF, Blaszkowsky LS, Thayer SP, Halpern EF, Harisinghani MG
Added Value of Selected Images Embedded Into Radiology Reports to Referring Clinicians.
J Am Coll Radiol. 2010;7(3):205-210 - PMID: 20193926 - PMCID: PMC3086392
Shah K
Imaging Fate of Stem Cells at a Cellular Resolution in the Brains of Mice.
Methods Mol Biol. 2010;680:91-101 - PMID: 21153375
Chen HH, Josephson L, Sosnovik DE
Imaging of apoptosis in the heart with nanoparticle technology.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2010;3(1):86-99 - PMID: 20945336 - PMCID: PMC3086683
Huang S, Sosnovik DE
Molecular and Microstructural Imaging of the Myocardium.
Curr Cardiovasc Imaging Rep. 2010;3(1):26-33 - PMID: 20689659 - PMCID: PMC2916196
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