SPECT-CT imaging facility

The overall goal of this facility is to provide SPECT imaging capabilities with or without high-resolution CT co-registration. The primary use of the facility is for the development and validation of novel radiolabeled imaging ligands which can be used for tumor detection, cell tracking, diagnosis of autoimmune diseases or vulnerable plaque localization.

Gammamedica Chamber

The most recently installed system is a high resolution X-SPECT™ system (Gamma Medica, Northridge, CA, USA). The SPECT system has 2 gamma detectors, which can be equipped with either parallel hole or pinhole collimators, the latter with exchangeable pinhole diameters. The system can be used with various isotopes, most frequently 111In and 99mTc. The spatial resolution for the SPECT system is about 1 mm.

Fusion

The CT detector is mounted on the same gantry as the gamma detectors, It has a pixel size of 75 µm and allows the acquisition of a 512x512x512 matrix with reconstruction in about 15 minutes. The CT data can be fused with the SPECT data.

Publications

  1. Pittet MJ, Grimm J, Berger CR, Tamura T, Wojtkiewicz G, Nahrendorf M, Romero P, Swirski FK, Weissleder R. In vivo imaging of T cell delivery to tumors after adoptive transfer therapy. Proc Natl Acad Sci U S A. 2007;104(30):12457-61
  2. Campanella GS, Grimm J, Manice LA, Colvin RA, Medoff BD, Wojtkiewicz GR, Weissleder R, Luster AD. Oligomerization of CXCL10 is necessary for endothelial cell presentation and in vivo activity. J Immunol. 2006 Nov 15;177(10):6991-8.
  3. Querol Sans M, Chen JW, Weissleder R, Bogdanov AA. Myeloperoxidase Activity Imaging Using %sup67Ga Labeled Substrate. Mol Imaging Biol. 2005;:1-8.
  4. Kelly K, Alencar H, Funovics M, Mahmood U, Weissleder R. Detection of invasive colon cancer using a novel, targeted, library-derived fluorescent peptide. Cancer Research. 2004;64(17):6247-51