Optical tomography of turbid media has so far been limited by systems that require fixed geometries or measurements employing fibers. We have been developing technologies that records noncontact optical measurements from diffuse media of arbitrary shapes and retrieves the three-dimensional surface information of the diffuse medium.
Schematic shows the 1st generation FMT system setup using a conventional CCD camera and a 3d photosymmetry camera employed. The inset shows the resin phantom imaged in this study.
We have also developed a novel method method for modeling the composite photon propagation in diffuse media and in air which was then applied to fluorescence reconstructions.
Our approach offers significant experimental simplicity and yields high-information-content
datasets. An example of the performance of this tomographic approach is shown in Figure 2 using phantoms and animals..
Experimental results from imaging a diffusive solid half cylinder containing two fluorescent tubes (a) Rendering of tube surface and the relative source of sources (red) and virtual detectors (blue). (b) Imaging of two tubes, the left tube at double the fluorchrome concentration of the right tube. (c) Imaging o f the same tubes at equal fluorochrome concentrations.
3D surface rendering and area capture mapping