Free Space Tomography

Recently the capacity to resolve molecular function and gene expression in whole animals has been proven in vivo. When probing with light, the ideal experimental configuration would be such that the sources and detectors are not in contact with the scattering medium, offering simple experimental procedures and yielding large numbers of tomographic projections. We have developed a theoretical workframe to quantitavely acquire photon signals from arbritrary surfaces with detectors of arbritrary locations. The experimental set up used for initial measurements is shown in Figure 1 and experimental validation of the theory developed is shown in Figure 2.

Setupfreespace

Figure 1.
Experimental setup and geometry assumed for the measurements shown in figure 2.

Freespace1

Figure 2.
Experimental normalized Born intensity data (solid lines) and theoretical predictions (bullets) for free space optical measurements from the half cylinder in Fig. 1 for the three different source positions shown on Fig.1 as small spheres at y=0.

For details see Ripoll J., et. al. Phys. Rev. Lett. 91(10): 103901-1-4 (2003)