Fluorescence Tomography
Claudio Vinegoni, PhD

Co-registration of magnetic resonance imaging (MRI) and fluorescence-mediated molecular tomography (FMT). The grayscale depicts the anatomical information obtained using MRI from a mouse model implanted with an HT1080 carcinoma in the mammary pad. The color image is the first in vivo FMT image. The image represents the spatial variation of cathespin B in the animal, obtained at the coronal level of the tumor. The tumor seen on the MR image is congruent with high cathepsin B concentration seen on the FMT image. FMT can target and quantify three-dimensionally a variety of different enzymes associated with carcinogenesis and pathogenesis. Thus molecular specificity can be achieved and used for diagnostic or treatment strategies.