Biomarker Discovery
John Chen, MD, PhD

One of the interests of our group is to translate the genetic differences that exist among different people and diseases into useful targets for molecular imaging. To accomplish this we utilize molecular profiling techniques to identify molecular signatures specific for disease and then image signature expression using various imaging modalities.

In this particular image we have taken advantage of the overexpression of the transferrin receptor on a cancer cell line to demonstrate that differences in receptor level can be measured in a mouse brain tumor model using Magnetic Resonance Imaging. Tumor on left overexpresses receptor and is more detectable by MRI.