Angiogenesis in Tumors
Alex R. Guimaraes, MD, PhD

Trans-cutaneous in vivo confocal fluorescence image of an anti-CD31-Cy5.5 conjugate which binds to tumor neovasculature (red). Tumor cells express green fluorescent protein (GFP).

Imaging of individual endothelial cells is possible in live animals without the use of implanted glass chambers. The image was obtained using a transcutaneous multiphoton/confocal microscope designed by Dr. Charles Lin, Wellman Laser Center, Department of Dermatology, MGH