Umar Mahmood, MD, PhD
Associate Professor of Radiology, Harvard Medical School
Director, CMIR Mouse Imaging Program
Phone: 617-726-6477
Email: umahmood@mgh.harvard.edu
Overall, my research interests can be divided into two themes: optimization
of molecular imaging of specific disease models and instrumentation development
for small animal imaging. In both cases, a spectrum of imaging modalities
are employed. Imaging technologies we are utilizing and improving for rodent
imaging include optical techniques (reflective and tomographic), MR, nuclear
(planar and SPECT), and CT. Our technological improvements have been driven
by the understanding that clinical imaging systems are optimized for humans
and that marked improvements in spatial resolution and signal-to-noise ratio
characteristics are achieved by focusing on the geometry and scale of rodents,
mostly mice, we use as our disease models.
Specific projects which are currently underway include:
Animal models
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Optical imaging of mouse models of cancer, cardiovascular disease,
and inflammation/inflammatory arthritis
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Nuclear imaging (planar/SPECT) of mouse/rat models of cancer, arthritis,
and gene delivery
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MR imaging of transgenic mice for evaluation of therapy
Technology development
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Optimization of reflective and catheter-based small animal optical
imaging
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MR small animal imaging optimization, including coil and pulse sequence
modification
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Nuclear planar, SPECT, and newer technology development (coded aperture,
new detectors)
My clinical interests are primarily in body imaging and interventional procedures.
Publications
Kelly KA, Bardeesy N, Anbazhagan R, Gurumurthy S, Berger J, Alencar H, Depinho RA, Mahmood U, Weissleder R
Targeted Nanoparticles for Imaging Incipient Pancreatic Ductal Adenocarcinoma.
Gee MS, Upadhyay R, Bergquist H, Alencar H, Reynolds F, Maricevich M, Weissleder R, Josephson L, Mahmood U
Human Breast Cancer Tumor Models: Molecular Imaging of Drug Susceptibility and Dosing during HER2/neu-targeted Therapy.
Lin KY, Maricevich M, Bardeesy N, Weissleder R, Mahmood U
In vivo quantitative microvasculature phenotype imaging of healthy and malignant tissues using a fiber-optic confocal laser microprobe.
Transl Oncol. 2008;1: 84-94
Wu HJ, Sawaya H, Binstadt B, Brickelmaier M, Blasius A, Gorelik L, Mahmood U, Weissleder R, Carulli J, Benoist C, Mathis D.
Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk
Mahmood U, Wallace MB
Molecular imaging in gastrointestinal disease.
Gastroenterology. 2007;132(1): 11-4
Arwert E, Hingtgen S, Figueiredo JL, Bergquist H, Mahmood U, Weissleder R, Shah K.
Visualizing the dynamics of EGFR activity and antiglioma therapies in vivo
Izmailova ES, Paz N, Alencar H, Chun M, Schopf L, Hepperle M, Lane JH, Harriman G, Xu Y, Ocain T, Weissleder R, Mahmood U, Healy AM, Jaffee B
Use of molecular imaging to quantify response to IKK-2 inhibitor treatment in murine arthritis.
Kozloff KM, Weissleder R, Mahmood U
Non-Invasive Optical Detection of Bone Mineral.
Alencar H, Funovics MA, Figueiredo J, Sawaya H, Weissleder R, Mahmood U
Colonic Adenocarcinomas: Near-Infrared Microcatheter Imaging of Smart Probes for Early Detection.
Radiology. 2007;244(1): 232-8
Montet X, Figueiredo JL, Alencar H, Ntziachristos V, Mahmood U, Weissleder R.
Tomographic fluorescence imaging of tumor vascular volume in mice.
Upadhyay R, Sheth RA, Weissleder R, Mahmood U
Quantitative Real-time Catheter-based Fluorescence Molecular Imaging in Mice.
Gee MS, Upadhyay R, Bergquist H, Weissleder R, Josephson L, Mahmood U
Multiparameter noninvasive assessment of treatment susceptibility, drug target inhibition and tumor response guides cancer treatment.
Tam JM, Upadhyay R, Pittet MJ, Weissleder R, Mahmood U
Improved in vivo whole-animal detection limits of green fluorescent protein-expressing tumor lines by spectral fluorescence imaging.
Sheth RA, Upadhyay R, Weissleder R, Mahmood U
Real-time multichannel imaging framework for endoscopy, catheters, and fixed geometry intraoperative systems.
Mahmood U, Upadhyay R
Current and Future Imaging Paradigms in Colorectal Cancer
Seminars in Colon and Rectal Surgery. 2007;18(2): 132-138
Binstadt BA, Patel PR, Alencar H, Nigrovic PA, Lee DM, Mahmood U, Weissleder R, Mathis D, Benoist C
Particularities of the vasculature can promote the organ specificity of autoimmune attack.
Ji H, Li D, Chen L, Shimamura T, Kobayashi S, McNamara K, Mahmood U, Mitchell A, Sun Y, Al-Hashem R, Chirieac LR, Padera R, Bronson RT, Kim W, Janne PA, Shapiro GI, Tenen D, Johnson BE, Weissleder R, Sharpless NE, Wong KK
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies.
Zhang M, Alicot EM, Chiu I, Li J, Verna N, Vorup-Jensen T, Kessler B, Shimaoka M, Chan R, Friend D, Mahmood U, Weissleder R, Moore FD, Carroll MC
Identification of the target self-antigens in reperfusion injury.
Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA
Both p16Ink4a and the p19Arf-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse.
Deramaudt TB, Takaoka M, Upadhyay R, Bowser MJ, Porter J, Lee A, Rhoades B, Johnstone CN, Weissleder R, Hingorani SR, Mahmood U, Rustgi AK
N-Cadherin and Keratinocyte Growth Factor Receptor Mediate the Functional Interplay between Ki-RASG12V and p53V143A in Promoting Pancreatic Cell Migration, Invasion, and Tissue Architecture Disruption.
Funovics MA, Alencar H, Montet X, Weissleder R, Mahmood U
Simultaneous fluorescence imaging of protease expression and vascularity during murine colonoscopy for colonic lesion characterization.
Gastrointest Endosc. 2006;64(4): 589-97
Newton JR, Kelly KA, Mahmood U, Weissleder R, Deutscher SL
In vivo selection of phage for the optical imaging of PC-3 human prostate carcinoma in mice.
Trehin R, Figueiredo JL, Pittet M, Weissleder R, Josephson L, Mahmood U.
Fluorescent Nanoparticle Uptake for Brain Tumor Visualization
Mahmood U
Can a clinically used chemoembolization vehicle improve transgene delivery?
Messerli SM, Prabhakar S, Tang Y, Mahmood U, Weissleder R, Bronson R, Martuza R, Rabkin S, Breakefield XO
Treatment of schwannomas with an oncolytic recombinant herpes simplex virus in murine models of neurofibromatosis type 2.
Hum Gene Ther. 2006;17(1): 20-30
Turvey SE, Swart E, Denis MC, Mahmood U, Benoist C, Weissleder R, Mathis D.
Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes
Kim YR, Yudina A, Figueiredo J, Reichardt W, Hu-Lowe D, Petrovsky A, Kang HW, Torres D, Mahmood U, Weissleder R, Bogdanov AA Jr.
Detection of Early Antiangiogenic Effects in Human Colon Adenocarcinoma Xenografts: In vivo Changes of Tumor Blood Volume in Response to Experimental VEGFR Tyrosine Kinase Inhibitor
Alencar H, Mahmood U, Kawano Y, Hirata T, Weissleder R
Novel Multiwavelength Microscopic Scanner for Mouse Imaging.
Figueiredo JL, Alencar H, Weissleder R, Mahmood U
Near infrared thoracoscopy of tumoral protease activity for improved detection of peripheral lung cancer.
Int J Cancer. 2005;118(11): 2672-7
Alencar H, King R, Funovics M, Stout C, Weissleder R, Mahmood U.
A novel mouse model for segmental orthotopic colon cancer
Int J Cancer. 2005;117(3): 335-9
Messerli SM, Prabhakar S, Tang Y, Mahmood U, Weissleder R, Bronson R, Martuza R, Rabkin S, Breakefield XO
Treatment of Schwannomas with an Oncolytic Recombinant Herpes Simplex Virus in Murine Models of Neurofibromatosis Type 2.
Hum Gene Ther. 2005;17(1): 20-30
Brown AB, Mahmood U, Cortes ML, Tang Y, Dai G, Stemmer-Rachamimov A, Prabhakar S, Leishear K, Onda H, Kwiatkowski D, Weissleder R, Breakefield X
Magnetic resonance imaging and characterization of spontaneous lesions in a transgenic mouse model of tuberous sclerosis as a model for endothelial cell-based transgene delivery.
Chen WT, Mahmood U, Weissleder R, Tung CH
Arthritis imaging using a near-infrared fluorescence folate-targeted probe
Mahmood U, Josephson L
Molecular MR Imaging Probes
Pivovarov M, Bhandary G, Mahmood U, Zahlmann G, Naraghi M, Weissleder R
MIPortal: A High Capacity Server for Molecular Imaging Research.
Wunder A, Schellenberger E, Mahmood U, Bogdanov A Jr, Muller-Ladner U, Weissleder R, Josephson L.
Methotrexate-induced accumulation of fluorescent annexin v in collagen-induced arthritis
Mol Imaging. 2005;4(1): 1-6
Denis MC, Mahmood U, Benoist C, Mathis D, Weissleder R
Imaging inflammation of the pancreatic islets in type 1 diabetes.
P Natl Acad Sci U S A. 2004;101(34): 12634-9
Kelly K, Alencar H, Funovics M, Mahmood U, Weissleder R
Detection of invasive colon cancer using a novel, targeted, library-derived fluorescent peptide.
Wunder A, Tung CH, Muller-Ladner U, Weissleder R, Mahmood U
In vivo imaging of protease activity in arthritis: a novel approach for monitoring treatment response.
Mahmood U
Can MR Imaging Be Used to Track Delivery of Intravascularly Administered Stem Cells?
Radiology. 2004;233(3): 625-6
Funovics MA, Weissleder R, Mahmood U
Catheter-based in vivo imaging of enzyme activity and gene expression: feasibility study in mice.
Mahmood U
Near infrared optical applications in molecular imaging. Earlier, more accurate assessment of disease presence, disease course, and efficacy of disease treatment.
IEEE Eng Med Biol. 2004;23(4): 58-66
Kircher MF, Mahmood U, King RS, Weissleder R, Josephson L
A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation
Mahmood U, Weissleder R
Near-infrared optical imaging of proteases in cancer
Mol Cancer Ther. 2003;2: 489-96
Josephson L, Mahmood U, Wunderbaldinger P, Tang Y, Weissleder R
Pan and sentinel lymph node visualization using a near-infrared fluorescent probe
Mol Imaging. 2003;2: 18-23
Funovics MA, Alencar H, Su HS, Khazaie K, Weissleder R, Mahmood U
Miniaturized multichannel near infrared endoscope for mouse imaging
Mol Imaging. 2003;2: 350-7
Ji H, Ohmura K, Mahmood U, Lee DM, Hofhuis FM, Boackle SA, Takahashi K, Holers VM, Walport M, Gerard C, Ezekowitz A, Carroll MC, Brenner M, Weissleder R, Verbeek JS, Duchatelle V, Degott C, Benoist C, Mathis D
Arthritis critically dependent on innate immune system players
Chen J, Tung CH, Mahmood U, Ntziachristos V, Gyurko R, Fishman MC, Huang PL, Weissleder R
In vivo imaging of proteolytic activity in atherosclerosis
Mahmood U, Tung CH, Tang Y, Weissleder R
Feasibility of in vivo multichannel optical imaging of gene expression: experimental study in mice
Josephson L, Kircher MF, Mahmood U, Tang Y, Weissleder R
Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes
Bioconjug Chem. 2002;13: 554-60
Schellingerhout D, Accorsi R, Mahmood U, Idoine J, Lanza RC, Weissleder R
Coded aperture nuclear scintigraphy: a novel small animal imaging technique
Mahmood U, Weissleder R
Some tools for molecular imaging
Bremer C, Bredow S, Mahmood U, Weissleder R, Tung CH
Optical imaging of matrix metalloproteinase-2 activity in tumors: feasibility study in a mouse model
Radiology. 2001;221: 523-9
Weissleder R, Mahmood U
Molecular imaging
Bremer C, Ntziachristos V, Mahmood U, Tung CH, Weissleder R
[Progress in optical imaging]
Weissleder R, Moore A, Mahmood U, Bhorade R, Benveniste H, Chiocca EA, Basilion JP
In vivo magnetic resonance imaging of transgene expression
Tung CH, Mahmood U, Bredow S, Weissleder R
In vivo imaging of proteolytic enzyme activity using a novel molecular reporter
Weissleder R, Tung CH, Mahmood U, Bogdanov A Jr
In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
Nat Biotechnol. 1999;17: 375-8
Mahmood U, Tung CH, Bogdanov A Jr, Weissleder R
Near-infrared optical imaging of protease activity for tumor detection
Tung CH, Bredow S, Mahmood U, Weissleder R
Preparation of a cathepsin D sensitive near-infrared fluorescence probe for imaging
Bioconjug Chem. 1999;10: 892-6
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