Farouc Jaffer, MD, PhD
Assistant Professor of Medicine, Harvard Medical School
Director, Cardiovascular Molecular Imaging Program, CMIR
Assistant in Medicine and Attending Interventional Cardiologist, Massachusetts General Hospital
Assistant in Research, Department of Radiology, Massachusetts General Hospital
Phone: 617-724-9353
Email: fjaffer@mgh.harvard.edu
Our lab is interested in applying molecular imaging technology to 1) understand the evolution and therapy of inflammation in atherosclerosis though serial,
high-resolution imaging and 2) developed translatable, catheter-based fluorescence technology to study vascular disease in human coronary sized arteries
Active research interests include:
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Multimodality molecular imaging of atherothrombotic vascular disease
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Intravascular catheter-based fluorescence molecular imaging in preclinical models
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Nanotechnological therapies for atherosclerosis and thrombosis
Publications
Aikawa E, Aikawa M, Libby P, Figueiredo JL, Rusanescu G, Iwamoto Y, Fukuda D, Kohler RH, Shi GP, Jaffer FA, Weissleder R
Arterial and Aortic Valve Calcification Abolished by Elastolytic Cathepsin S Deficiency in Chronic Renal Disease.
Jaffer FA
Assessing niacin as an atherosclerosis therapeutic agent valuable insights provided by high-resolution vascular magnetic resonance imaging.
J Am Coll Cardiol. 2009;54(19):1795-6 - PMID: 19874993
Jaffer FA, Libby P, Weissleder R
Optical and Multimodality Molecular Imaging. Insights Into Atherosclerosis.
McCarthy JR, Patel P, Botnaru I, Haghayeghi P, Weissleder R, Jaffer FA
Multimodal Nanoagents for the Detection of Intravascular Thrombi.
Osborn EA, Jaffer FA
The year in molecular imaging.
J Am Coll Cardiol Img. 2009;2:97-113 - PMID: 19356541
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Jaffer FA, Vinegoni C, John MC, Aikawa E, Gold HK, Finn AV, Ntziachristos V, Libby P, Weissleder R
Real-Time Catheter Molecular Sensing of Inflammation in Proteolytically Active Atherosclerosis.
Nahrendorf M, Aikawa E, Figueiredo JL, Stangenberg L, van den Borne S, Blankesteijn M, Sosnovik D, Jaffer F, Tung CH, Weissleder R
Transglutaminase activity in acute infarcts predicts healing outcome and let ventricular remodelling : implications for FXIII therapy and antithrombin use in myocardial infarction
Eur Heart J. 2008;29:445-454 - PMID: 18276618
Osborn EA, Jaffer FA
Advances in molecular imaging of atherosclerotic vascular disease.
Curr Opin Cardiol. 2008;23:620-8 - PMID: 18830079
Chang K, Jaffer F
Advances in fluorescence imaging of the cardiovascular system.
J Nucl Cardiol. 2008;15(3):417-28 - PMID: 18513648
Korngold EC, Jaffer FA, Weissleder R, Sosnovik DE
Noninvasive imaging of apoptosis in cardiovascular disease.
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Aikawa E, Nahrendorf M, Figueiredo JL, Swirski F, Shtatland T, Kohler RH, Jaffer F, Aikawa M, Weissleder R.
Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo.
Circulation. 2007;116(24):2841-50 - PMID: 18040026
Jaffer FA, Libby P, Weissleder R
Molecular imaging of cardiovascular disease.
Circulation. 2007;116(9):1052-61 - PMID: 17724271
Jaffer FA, Kim DE, Quinti L, Tung CH, Aikawa E, Pande AN, Kohler RH, Shi GP, Libby P, Weissleder R
Optical Visualization of Cathepsin K Activity in Atherosclerosis With a Novel, Protease-Activatable Fluorescence Sensor.
Circulation. 2007;115(17):2292-8 - PMID: 17420353
Aikawa E, Nahrendorf M, Sosnovik D, Lok VM, Jaffer FA, Aikawa M, Weissleder R
Multimodality Molecular Imaging Identifies Proteolytic and Osteogenic Activities in Early Aortic Valve Disease.
Circulation. 2007;115:377-386 - PMID: 17224478
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Nahrendorf M, Jaffer FA, Kelly KA, Sosnovik DE, Aikawa E, Libby P, Weissleder R
Noninvasive Vascular Cell Adhesion Molecule-1 Imaging Identifies Inflammatory Activation of Cells in Atherosclerosis.
Circulation. 2006;114:1504-1511 - PMID: 17000904
Nahrendorf M, Hu K, Frantz S, Jaffer F, Tung CH, Hiller KH, Voll S, Nordbeck P, Sosnovik D, Gattenlohner S, Novikov M, Dickneite G, Reed G, Jakob P, Rosenzweig A, Bauer W, Weissleder R, Ertl G.
Factor XIII Deficiency Causes Cardiac Rupture, Impairs Wound Healing, and Aggravates Cardiac Remodeling in Mice with Myocardial Infarction
Circulation. 2006;113(9):1196-1202 - PMID: 16505171
Jaffer F, Libby P, Weissleder R.
Molecular and Cellular Imaging of Atherosclerosis, Emerging Applications
J Am Coll Cardiol. 2006;47:1328-1338 - PMID: 16580517
Swirski FK, Pittet MJ, Kircher MF, Aikawa E, Jaffer FA, Libby P, Weissleder R
Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease.
McCarthy J, Jaffer F, Weissleder R.
A Macrophage Targeted Theranostic Nanoparticle for Biomedical Applications
Small. 2006;2(8-9):983-987 - PMID: 17193154
Jaffer FA, Sosnovik DE, Nahrendorf M, Weissleder R
Molecular imaging of myocardial infarction.
J Mol Cell Cardiol. 2006;41:921-933 - PMID: 17067633
Jaffer F, Nahrendorf M, Sosnovik D, Kelly KA, Aikawa E, Weissleder R
Cellular Imaging of Inflammation in Atherosclerosis Using Magnetofluorescent Nanomaterials
Mol Imaging. 2006;(5) 2 :85-92 - PMID: 16954022
Pande AN, Kohler RH, Aikawa E, Weissleder R, Jaffer FA
Detection of macrophage activity in atherosclerosis in vivo using multichannel, high-resolution laser scanning fluorescence microscopy.
J Biomed Opt. 2006;11(2):21009 - PMID: 16674184
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Jaffer F, Weissleder R
Molecular Imaging in the Clinical Arena
JAMA-J Am Med Assoc. 2005;293(7):855-62 - PMID: 15713776
Kim DE, Jaffer FA, Weissleder R, Tung CH, Schellingerhout D.
Near-infrared fluorescent imaging of cerebral thrombi and blood-brain barrier disruption in a mouse model of cerebral venous sinus thrombosis
J Cerebr Blood F Met. 2005;25(2):226-33 - PMID: 15678125
Tung CH, Quinti L, Jaffer F, Weissleder R
A Branched Fluorescent Peptide Probe for Imaging of Activated Platelets
Mol Pharmacol. 2005;2:92-95 - PMID: 15804182
Zhu B, Jaffer F, Nztiachristos V, Weissleder R
Development of a near infrared fluorescence catheter: operating characteristics and feasibility for atherosclerotic plaque detection
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Jaffer FA, Tung CH, Wykrzykowska JJ, Ho NH, Houng AK, Reed GL, Weissleder R
Molecular Imaging of Factor XIIIa Activity in Thrombosis Using a Novel, Near-Infrared Fluorescent Contrast Agent That Covalently Links to Thrombi.
Circulation. 2004;110(2):170-6 - PMID: 15210587
Jaffer FA, Weissleder R
Seeing within: molecular imaging of the cardiovascular system
Circ Res. 2004;94(4):433-45 - PMID: 15001542
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Tung CH, Ho NH, Zeng Q, Tang Y, Jaffer FA, Reed GL, Weissleder R
Novel Factor XIII Probes for Blood Coagulation Imaging
Chembiochem. 2003;4:897-899 - PMID: 12964167
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Jaffer FA, Tung CH, Gerszten RE, Weissleder R
In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe
Arterioscler Thromb Vasc Biol. 2002;22:1929-35 - PMID: 12426227
Tung CH, Gerszten RE, Jaffer FA, Weissleder R
A novel near-infrared fluorescence sensor for detection of thrombin activation in blood
Chembiochem. 2002;3:207-11 - PMID: 11921399
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