Farouc Jaffer, MD, PhD
Associate Professor of Medicine, Harvard Medical School
Director of Vascular Imaging, Cardiovascular Molecular Imaging Program, CMIR
Assistant in Medicine and Attending Interventional Cardiologist, Massachusetts General Hospital
Assistant in Research, Department of Radiology, Massachusetts General Hospital

Phone: 617-724-9353
Email: fjaffer@mgh.harvard.edu

Our lab is interested in applying molecular imaging technology to 1) understand the evolution and therapy of inflammation in atherosclerosis though serial, high-resolution imaging and 2) developed translatable, catheter-based fluorescence technology to study vascular disease in human coronary sized arteries

Active research interests include:

  1. Multimodality molecular imaging of atherothrombotic vascular disease

  2. Intravascular catheter-based fluorescence molecular imaging in preclinical models

  3. Nanotechnological therapies for atherosclerosis and thrombosis

Min JK, Leipsic J, Pencina MJ, Berman DS, Koo BK, van Mieghem C, Erglis A, Lin FY, Dunning AM, Apruzzese P, Budoff MJ, Cole JH, Jaffer FA, Leon MB, Malpeso J, Mancini GB, Park SJ, Schwartz RS, Shaw LJ, Mauri L
Diagnostic Accuracy of Fractional Flow Reserve From Anatomic CT Angiography.
JAMA-J Am Med Assoc. 2012;:1-9 - PMID: 22922562
Moon H, Park HE, Kang J, Lee H, Cheong C, Lim YT, Ihm SH, Seung KB, Jaffer FA, Narula J, Chang K, Hong KS
Noninvasive Assessment of Myocardial Inflammation by Cardiovascular Magnetic Resonance in a Rat Model of Experimental Autoimmune Myocarditis.
Circulation. 2012;125(21):2603-12 - PMID: 22550157
Ripplinger CM, Kessinger CW, Li C, Kim JW, McCarthy JR, Weissleder R, Henke PK, Lin CP, Jaffer FA
Inflammation Modulates Murine Venous Thrombosis Resolution In Vivo: Assessment by Multimodal Fluorescence Molecular Imaging.
Arterioscler Thromb Vasc Biol. 2012;32(11):2616-24 - PMID: 22995524 - PMCID: PMC3516622
Hara T, Bhayana B, Thompson B, Kessinger CW, Khatri A, McCarthy JR, Weissleder R, Lin CP, Tearney GJ, Jaffer FA
Molecular imaging of fibrin deposition in deep vein thrombosis using fibrin-targeted near-infrared fluorescence.
JACC Cardiovasc Imaging. 2012;5(6):607-15 - PMID: 22698530 - PMCID: PMC3376390
McCarthy JR, Sazonova IY, Erdem SS, Hara T, Thompson BD, Patel P, Botnaru I, Lin CP, Reed GL, Weissleder R, Jaffer FA
Multifunctional nanoagent for thrombus-targeted fibrinolytic therapy.
Nanomedicine (Lond). 2012;7(7):1017-28 - PMID: 22348271 - PMCID: PMC3360120
Taqueti VR, Jaffer FA
High-resolution molecular imaging via intravital microscopy: illuminating vascular biology in vivo.
Integr Biol (Camb). 2012;5(2):278-90 - PMID: 23135362 - PMCID: PMC3558556
Saxena A, Kessinger CW, Thompson B, McCarthy JR, Iwamoto Y, Lin CP, Jaffer FA
High-Resolution Optical Mapping of Inflammatory Macrophages Following Endovascular Arterial Injury.
Mol Imaging Biol. 2012;15(3):282-9 - PMID: 23090852 - PMCID: PMC3650124
Erdem SS, Sazonova IY, Hara T, Jaffer FA, McCarthy JR
Detection and treatment of intravascular thrombi with magnetofluorescent nanoparticles.
Method Enzymol. 2012;508:191-209 - PMID: 22449927
Rosenthal A, Jaffer FA, Ntziachristos V
Intravascular multispectral optoacoustic tomography of atherosclerosis: prospects and challenges.
Imaging Med. 2012;4(3):299-310 - PMID: 23144663 - PMCID: PMC3493570