Farouc Jaffer, MD, PhD
Assistant Professor of Medicine, Harvard Medical School Director, Cardiovascular Molecular Imaging Program, CMIR Assistant in Medicine and Attending Interventional Cardiologist, Massachusetts General Hospital Assistant in Research, Department of Radiology, Massachusetts General Hospital Phone: 617-724-6242 Email: fjaffer@mgh.harvard.edu My primary research is in translational molecular imaging of the cardiovascular system. My main goal is to develop and validate new near infrared fluorescence and magnetic resonance imaging agents that could eventually be used to specifically image molecular aspects of human cardiovascular disease in vivo. Active research interests include:
Publications Transglutaminase activity in acute infarcts predicts healing outcome and let ventricular remodelling : implications for FXIII therapy and antithrombin use in myocardial infarction
Eur Heart J. 2008;29:445-454
Advances in fluorescence imaging of the cardiovascular system.
J Nucl Cardiol. 2008;15(3):417-28
Optical Visualization of Cathepsin K Activity in Atherosclerosis With a Novel, Protease-Activatable Fluorescence Sensor.
Circulation. 2007;115(17):2292-8
Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo.
Circulation. 2007;116(24):2841-50
Molecular imaging of cardiovascular disease.
Circulation. 2007;116(9):1052-61
Multimodality Molecular Imaging Identifies Proteolytic and Osteogenic Activities in Early Aortic Valve Disease.
Circulation. 2007;115:377-386
Noninvasive imaging of apoptosis in cardiovascular disease.
Heart Fail Rev. 2007;:ePub
Noninvasive Vascular Cell Adhesion Molecule-1 Imaging Identifies Inflammatory Activation of Cells in Atherosclerosis.
Circulation. 2006;114:1504-1511
Factor XIII Deficiency Causes Cardiac Rupture, Impairs Wound Healing, and Aggravates Cardiac Remodeling in Mice with Myocardial Infarction
Circulation. 2006;113(9):1196-1202
Molecular and Cellular Imaging of Atherosclerosis, Emerging Applications
J Am Coll Cardiol. 2006;47:1328-1338
Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease.
P Natl Acad Sci U S A. 2006;103(27):10340-5
A Macrophage Targeted Theranostic Nanoparticle for Biomedical Applications
Small. 2006;2(8-9):983-987
Molecular imaging of myocardial infarction.
J Mol Cell Cardiol. 2006;41:921-933
Cellular Imaging of Inflammation in Atherosclerosis Using Magnetofluorescent Nanomaterials
Mol Imaging. 2006;(5) 2 :85-92
Detection of macrophage activity in atherosclerosis in vivo using multichannel, high-resolution laser scanning fluorescence microscopy.
J Biomed Opt. 2006;11(2):21009
Molecular Imaging in the Clinical Arena
JAMA. 2005;293(7):855-62
Near-infrared fluorescent imaging of cerebral thrombi and blood-brain barrier disruption in a mouse model of cerebral venous sinus thrombosis
J Cereb Blood F Met. 2005;25(2):226-33
A Branched Fluorescent Peptide Probe for Imaging of Activated Platelets
Mol Pharmacol. 2005;2:92-95
Development of a near infrared fluorescence catheter: operating characteristics and feasibility for atherosclerotic plaque detection
J Phys D Appl Phys. 2005;38:2701-2707
Molecular Imaging of Factor XIIIa Activity in Thrombosis Using a Novel, Near-Infrared Fluorescent Contrast Agent That Covalently Links to Thrombi.
Circulation. 2004;110(2):170-6
Seeing within: molecular imaging of the cardiovascular system
Circ Res. 2004;94(4):433-45
Novel Factor XIII Probes for Blood Coagulation Imaging
Chembiochem. 2003;4:897-899
In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe
Arterioscl Throm Vas. 2002;22:1929-35
A novel near-infrared fluorescence sensor for detection of thrombin activation in blood
Chembiochem. 2002;3:207-11
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Farouc Jaffer, MD, PhD