Mukesh Harisinghani, MD
Associate Professor of Radiology, Harvard Medical School
Assistant Radiologist, Dept. of Abdominal Imaging

Phone: 617-726-8396
Email: mharisinghani@mgh.harvard.edu

Design and conduct clinical trials and provide an avenue for clinical testing of novel imaging agents developed at CMIR.

Over the last several years we have conducted phase 1,2 and phase 3 clinical trials of monocrystalline iron oxides (1-2) for a number of applications. Current trials evaluate the efficacy of these agents to improve detection of subtle lymph node metastases in patients with prostate cancer (funded in part by RSNA) and renal cancer (funded in part by by SCBT).

My primary clinical interests lie in abdominal and pelvic MR imaging



Publications
Harisinghani M
Nanoparticle-enhanced MRI: are we there yet?
Lancet Oncol. 2008;9:814-815
Feldman AS, McDougal WS, Harisinghani MG
The potential of nanoparticle-enhanced imaging.
Urol Oncol. 2008;26(1):65-73
Guimaraes AR, Tabatabei S, Dahl D, McDougal WS, Weissleder R, Harisinghani MG
Pilot Study Evaluating Use of Lymphotrophic Nanoparticle-Enhanced Magnetic Resonance Imaging for Assessing Lymph Nodes in Renal Cell Cancer.
Urology. 2008;71(4):708-12
Li CS, Harisinghani MG, Lin WC, Braschi M, Hahn PF, Mueller PR
Enhancement Characteristics of Ultrasmall Superparamagnetic Iron Oxide Particle Within the Prostate Gland in Patients With Primary Prostate Cancer.
J Comput Assist Tomogr. 2008;32:523-528
Harisinghani M, Ross R, Guimaraes A, Weissleder R
Utility of a New Bolus-Injectable Nanoparticle for Clinical Cancer Staging
Neoplasia. 2007;(9)12:1160-1165
Saksena M, Harisinghani M, Hahn P, Kim J, Saokar A, King B, Weissleder R
Comparison of lymphotropic nanoparticle-enhanced MRI sequences in patients with various primary cancers.
Am J Roentgenol. 2006;187(6):W582-8
Harisinghani MG, Saksena MA, Hahn PF, King B, Kim J, Torabi MT, Weissleder R
Ferumoxtran-10-Enhanced MR Lymphangiography: Does Contrast-Enhanced Imaging Alone Suffice for Accurate Lymph Node Characterization?
Am J Roentgenol. 2006;186(1):144-8
Saksena MA, Saokar A, Harisinghani MG
Lymphotropic nanoparticle enhanced MR imaging (LNMRI) technique for lymph node imaging.
Eur J Radiol. 2006;58(3):367-74
Ross R, Harisinghani M
Prostate cancer imaging-what the urologic oncologist needs to know.
Radiol Clin North Am. 2006;44(5):711-22
Ross R, Harisinghani M
New clinical imaging modalities in prostate cancer.
Hematol Oncol Clin North Am. 2006;20(4):811-30
Saokar A, Braschi M, Harisinghani M
Lymphotrophic nanoparticle enhanced MR imaging (LNMRI) for lymph node imaging.
Abdom Imaging. 2006;:ePub
Shih HA, Harisinghani M, Zietman AL, Wolfgang JA, Saksena M, Weissleder R.
Mapping of nodal disease in locally advanced prostate cancer: Rethinking the clinical target volume for pelvic nodal irradiation based on vascular rather than bony anatomy
Int J Radiat Oncol. 2005;63(4):1262-9
Harisinghani MG, Saksena M, Ross RW, Tabatabaei S, Dahl D, McDougal S, Weissleder R
A pilot study of lymphotrophic nanoparticle-enhanced magnetic resonance imaging technique in early stage testicular cancer: a new method for noninvasive lymph node evaluation.
Urology. 2005;66(5):1066-71
Harisinghani MG, Weissleder R
Sensitive, noninvasive detection of lymph node metastases.
PLoS Med. 2004;1(3):e66
Harisinghani MG, Barentsz J, Hahn PF, Deserno WM, Tabatabaei S, van de Kaa CH, de la Rosette J, Weissleder R
Noninvasive detection of clinically occult lymph-node metastases in prostate cancer
N Engl J Med. 2003;348:2491-9
Harisinghani MG, Barentsz JO, Hahn PF, Deserno W, de la Rosette J, Saini S, Marten K, Weissleder R
MR lymphangiography for detection of minimal nodal disease in patients with prostate cancer
Acad Radiol. 2002;9 Suppl 2:S312-3
Harisinghani MG, Saini S, Weissleder R, Rubin D, deLange E, Harms S, Weinreb J, Small W, Sukerkar A, Brown JJ, Zelch J, Lucas M, Morris M, Hahn PF
Splenic imaging with ultrasmall superparamagnetic iron oxide ferumoxtran-10 (AMI-7227): preliminary observations
J Comput Assist Tomogr. 2001;25:770-6
Harisinghani MG, Jhaveri KS, Weissleder R, Schima W, Saini S, Hahn PF, Mueller PR
MRI contrast agents for evaluating focal hepatic lesions
Clin Radiol. 2001;56:714-25
Harisinghani MG, Saini S, Weissleder R, Hahn PF, Yantiss RK, Tempany C, Wood BJ, Mueller PR
MR lymphangiography using ultrasmall superparamagnetic iron oxide in patients with primary abdominal and pelvic malignancies: radiographic-pathologic correlation
Am J Roentgenol. 1999;172:1347-51
Schima W, Saini S, Petersein J, Weissleder R, Harisinghani M, Mayo-Smith W, Hahn PF
MR imaging of the liver with Gd-BOPTA: quantitative analysis of T1-weighted images at two different doses
J Magn Reson Imaging. 1999;10:80-3