Ralph Weissleder, MD, PhD
Professor, Harvard Medical School Director, Center for Molecular Imaging Research Director, Center for Systems Biology Phone: 617-643-3220 Email: rweissleder@mgh.harvard.edu My primary research interests lie in the field of in vivo molecular imaging. Specific research interests over the last 10 years have included the development of novel molecular probes for MR imaging, methods to image cell trafficking and homing, imaging of gene expression in vivo and development of novel imaging technologies, in particular different magnetic resonance and optical imaging methods. These basic research interests go hand-in hand with my clinical interests in interventional and oncologic imaging. Specific examples of translational research have included the development of novel magnetic nanoparticles for MR imaging; the development of enzyme activatable probes for the detection of early cancers by minimally invasive techniques such as laparoscopy; and clinical testing of long circulating polymers for angiogenesis imaging. Molecular libraries and screens: One of the current areas of interest is the creation and use of entire libraries of imaging agents and their screening to identify hits for molecular targets of interest. Using this approach we have identified unique molecules and nanomaterials with specificity for activated and resting macrophages, subsets of endothelial cells and specific tumor cells. Nanomaterials: Another area of interest is the exploration of novel nanomaterials to develop novel diagnostic and therapeutic agents. We have developed a series of new nanomaterials for specific applications in cancer and cardiovascular disease. Stem cells: Another long standing research interest has been the imaging and tracking of individual cell populations in vivo especially stem cells. While we developed methods of superparamagnetic cell labeling over 10 years ago, it has not been until very recently that the use of membrane translocation signals has afforded the much required higher loading capacity of cells. Having the necessary tools at hand, we are now interested in exploring how the localization and retrieval of cell populations in vivo will enable detailed analysis of specific stem cell and organ interactions critical for advancing the therapeutic use of stem cells. Another area of interest is the identification of new affinity ligands for different stem cell types to allow their visualization in vivo. Publications Lee H, Sun E, Ham D, Weissleder R
Chip-NMR biosensor for detection and molecular analysis of cells.
Nat Med. 2008;:ePub
Wurdinger T, Badr C, Pike L, de Kleine R, Weissleder R, Breakefield XO, Tannous BA
A secreted luciferase for ex vivo monitoring of in vivo processes.
Nat Methods. 2008;5:171-173
Nahrendorf M, Zhang H, Hembrador S, Panizzi P, Sosnovik D, Aikawa E, Libby P, Swirski F, Weissleder R.
Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis
Circulation. 2008;117:379-387
Nahrendorf M, Sosnovik D, Chen JW, Panizzi P, Figueiredo JL, Aikawa E, Libby P, Swirski FK, Weissleder R
Activatable Magnetic Resonance Imaging Agent Reports Myeloperoxidase Activity in Healing Infarcts and Noninvasively Detects the Antiinflammatory Effects of Atorvastatin on Ischemia-Reperfusion Injury.
Circulation. 2008;117(9):1153-60
Kircher M, Grimm J, Swirski FK, Libby P, Gerszten R, Allport J, Weissleder R
Noninvasive in vivo imaging of monocyte trafficking to atherosclerotic lesions.
Circulation. 2008;117:388-395
Kelly KA, Bardeesy N, Anbazhagan R, Gurumurthy S, Berger J, Alencar H, Depinho RA, Mahmood U, Weissleder R
Targeted Nanoparticles for Imaging Incipient Pancreatic Ductal Adenocarcinoma.
PLoS Med. 2008;5(4):e85
Korosoglou G, Weiss RG, Kedziorek DA, Walczak P, Gilson WD, Schar M, Sosnovik DE, Kraitchman DL, Boston RC, Bulte JW, Weissleder R, Stuber M
Noninvasive detection of macrophage-rich atherosclerotic plaque in hyperlipidemic rabbits using positive contrast magnetic resonance imaging.
J Am Coll Cardiol. 2008;52:483-91
Koh I, Hong R, Weissleder R, Josephson L
Sensitive NMR Sensors Detect Antibodies to Influenza.
Angew Chem Int Edit. 2008;47(22):4119-4121
Shaw SY, Westly EC, Pittet MJ, Subramanian A, Schreiber SL, Weissleder R
Perturbational profiling of nanomaterial biologic activity.
P Natl Acad Sci U S A. 2008;105:7387-7392
Chen JW, Breckwoldt MO, Aikawa E, Chiang G, Weissleder R
Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis.
Brain. 2008;131(Pt 4):1123-33
McCarthy JR, Weissleder R
Multifunctional magnetic nanoparticles for targeted imaging and therapy.
Adv Drug Deliv Rev. 2008;60:1241-1251
Kelly KA, Setlur SR, Ross R, Anbazhagan R, Waterman P, Rubin MA, Weissleder R
Detection of early prostate cancer using a hepsin-targeted imaging agent.
Cancer Res. 2008;68(7):2286-91
Shah K, Hingtgen S, Kasmieh R, Figueiredo JL, Garcia-Garcia E, Martinez-Serrano A, Breakefield X, Weissleder R
Bimodal viral vectors and in vivo imaging reveal the fate of human neural stem cells in experimental glioma model.
J Neurosci. 2008;28:4406-13
Nahrendorf M, Aikawa E, Figueiredo JL, Stangenberg L, van den Borne S, Blankesteijn M, Sosnovik D, Jaffer F, Tung CH, Weissleder R
Transglutaminase activity in acute infarcts predicts healing outcome and let ventricular remodelling : implications for FXIII therapy and antithrombin use in myocardial infarction
Eur Heart J. 2008;29:445-454
Gee MS, Upadhyay R, Bergquist H, Alencar H, Reynolds F, Maricevich M, Weissleder R, Josephson L, Mahmood U
Human Breast Cancer Tumor Models: Molecular Imaging of Drug Susceptibility and Dosing during HER2/neu-targeted Therapy.
Radiology. 2008;:ePub
Blois J, Yuan H, Smith A, Pacold ME, Weissleder R, Cantley LC, Josephson L
Slow Self-Activation Enhances The Potency of Viridin Prodrugs.
J Med Chem. 2008;:ePub
Sosnovik DE, Nahrendorf M, Weissleder R
Targeted imaging of myocardial damage.
Nat Clin Pract Card. 2008;5 Suppl 2:S63-70
Hilderbrand SA, Kelly KA, Niedre M, Weissleder R
Near Infrared Fluorescence-Based Bacteriophage Particles for Ratiometric pH Imaging.
Bioconjug Chem. 2008;:ePub
Barnes KR, Blois J, Smith A, Yuan H, Reynolds F, Weissleder R, Cantley LC, Josephson L
Fate of a Bioactive Fluorescent Wortmannin Derivative in Cells.
Bioconjug Chem. 2008;19:130-137
Sosnovik DE, Nahrendorf M, Weissleder R
Magnetic nanoparticles for MR imaging: agents, techniques and cardiovascular applications.
Basic Res Cardiol. 2008;103(2):122-30
Nahrendorf M, Sosnovik DE, Weissleder R
MR-optical imaging of cardiovascular molecular targets.
Basic Res Cardiol. 2008;103:87-94
Figueiredo JL, Passerotti CC, Sponholtz T, Nguyen HT, Weissleder R
A Novel Method of Imaging Calcium Urolithiasis Using Fluorescence.
J Urol. 2008;179:1610-1614
Taktak S, Weissleder R, Josephson L
Electrode Chemistry Yields a Nanoparticle-Based NMR Sensor for Calcium.
Langmuir. 2008;24 (14):7596-7598
Hong R, Cima MJ, Weissleder R, Josephson L
Magnetic microparticle aggregation for viscosity determination by MR.
Magn Reson Med. 2008;59:515-520
Korosoglou G, Tang L, Kedziorek D, Cosby K, Gilson WD, Vonken EJ, Schar M, Sosnovik D, Kraitchman DL, Weiss RG, Weissleder R, Stuber M
Positive contrast MR-lymphography using inversion recovery with ON-resonant water suppression (IRON).
J Magn Reson Imaging. 2008;27(5):1175-1180
Guimaraes AR, Tabatabei S, Dahl D, McDougal WS, Weissleder R, Harisinghani MG
Pilot Study Evaluating Use of Lymphotrophic Nanoparticle-Enhanced Magnetic Resonance Imaging for Assessing Lymph Nodes in Renal Cell Cancer.
Urology. 2008;71(4):708-12
Rusanescu G, Weissleder R, Aikawa E
Notch Signaling in Cardiovascular Disease and Calcification
Curr Cardiol Review. 2008;4(3):148-156
Gounaris E, Tung CH, Restaino C, Maehr R, Kohler R, Joyce JA, Plough HL, Barrett TA, Weissleder R, Khazaie K
Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth.
PLoS ONE. 2008;3:e2916
Lin KY, Maricevich M, Bardeesy N, Weissleder R, Mahmood U
In vivo quantitative microvasculature phenotype imaging of healthy and malignant tissues using a fiber-optic confocal laser microprobe.
Transl Oncol. 2008;1:84-94
Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R, Jacks T
Restoration of p53 function leads to tumour regression in vivo.
Nature. 2007;445:661-5
Kirsch DG, Dinulescu DM, Miller JB, Grimm J, Santiago PM, Young NP, Nielsen GP, Quade BJ, Chaber CJ, Schultz CP, Takeuchi O, Bronson RT, Crowley D, Korsmeyer SJ, Yoon SS, Hornicek FJ, Weissleder R, Jacks T
A spatially and temporally restricted mouse model of soft tissue sarcoma.
Nat Med. 2007;13(8):992-997
Swirski FK, Libby P, Aikawa E, Alcaide P, Luscinskas FW, Weissleder R, Pittet MJ
Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata
J Clin Invest. 2007;117(1):195-205
Kurozumi K, Hardcastle J, Thakur R, Yang M, Christoforidis G, Fulci G, Hochberg F, Weissleder R, Carson W, Chiocca A, Kaur B.
Effect of Tumor Microenvironment Modulation on the Efficacy of Oncolytic Virus Therapy
J Natl Cancer Inst. 2007;(99) 23:1768-1781
Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo JL, Libby P, Weissleder R, Pittet MJ
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions.
J Exp Med. 2007;204(12):3037-47
Wu HJ, Sawaya H, Binstadt B, Brickelmaier M, Blasius A, Gorelik L, Mahmood U, Weissleder R, Carulli J, Benoist C, Mathis D.
Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk
J Exp Med. 2007;204:1911-1922
Sosnovik DE, Nahrendorf M, Deliolanis N, Novikov M, Aikawa E, Josephson L, Rosenzweig A, Weissleder R, Ntziachristos V
Fluorescence Tomography and Magnetic Resonance Imaging of Myocardial Macrophage Infiltration in Infarcted Myocardium In Vivo.
Circulation. 2007;115:1384-1391
Sosnovik DE, Nahrendorf M, Weissleder R
Molecular magnetic resonance imaging in cardiovascular medicine.
Circulation. 2007;115(15):2076-86
Aikawa E, Nahrendorf M, Sosnovik D, Lok VM, Jaffer FA, Aikawa M, Weissleder R
Multimodality Molecular Imaging Identifies Proteolytic and Osteogenic Activities in Early Aortic Valve Disease.
Circulation. 2007;115:377-386
Jaffer FA, Libby P, Weissleder R
Molecular imaging of cardiovascular disease.
Circulation. 2007;116(9):1052-61
Jaffer FA, Kim DE, Quinti L, Tung CH, Aikawa E, Pande AN, Kohler RH, Shi GP, Libby P, Weissleder R
Optical Visualization of Cathepsin K Activity in Atherosclerosis With a Novel, Protease-Activatable Fluorescence Sensor.
Circulation. 2007;115(17):2292-8
Aikawa E, Nahrendorf M, Figueiredo JL, Swirski F, Shtatland T, Kohler RH, Jaffer F, Aikawa M, Weissleder R.
Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo.
Circulation. 2007;116(24):2841-50
Nahrendorf M, Sosnovik D, Waterman P, Swirski F, Pande A, Aikawa E, Figueiredo JL, Pittet M, Weissleder R.
Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct
Circ Res. 2007;100:1218-1225
Gounaris E, Erdman SE, Restaino C, Gurish MF, Friend DS, Gounari F, Lee DM, Zhang G, Glickman JN, Shin K, Rao VP, Poutahidis T, Weissleder R, McNagny KM, Khazaie K
Mast cells are an essential hematopoietic component for polyp development.
P Natl Acad Sci U S A. 2007;104:19977-82
Pittet M, Grimm J, Berger C, Tamura T, Wojtkiewicz G, Nahrendorf M, Romero P, Swirski F, Weissleder R.
In vivo imaging of T cell delivery to tumors after adoptive transfer therapy
P Natl Acad Sci U S A. 2007;104:12457-12461
Arwert E, Hingtgen S, Figueiredo JL, Bergquist H, Mahmood U, Weissleder R, Shah K.
Visualizing the dynamics of EGFR activity and antiglioma therapies in vivo
Cancer Res. 2007;67 (15):7335-7342
Corsten MF, Miranda R, Kasmieh R, Krichevsky AM, Weissleder R, Shah K
MicroRNA-21 Knockdown Disrupts Glioma Growth In vivo and Displays Synergistic Cytotoxicity with Neural Precursor Cell Delivered S-TRAIL in Human Gliomas.
Cancer Res. 2007;67(19):8994-9000
Fulci G, Dmitrieva N, Gianni D, Fontana EJ, Pan X, Lu Y, Kaufman CS, Kaur B, Lawler SE, Lee RJ, Marsh CB, Brat DJ, van Rooijen N, Rachamimov AS, Hochberg FH, Weissleder R, Martuza RL, Chiocca EA
Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses.
Cancer Res. 2007;67(19):9398-406
Izmailova ES, Paz N, Alencar H, Chun M, Schopf L, Hepperle M, Lane JH, Harriman G, Xu Y, Ocain T, Weissleder R, Mahmood U, Healy AM, Jaffee B
Use of molecular imaging to quantify response to IKK-2 inhibitor treatment in murine arthritis.
Arth Rheum. 2007;56(1):117-128
Kozloff KM, Weissleder R, Mahmood U
Non-Invasive Optical Detection of Bone Mineral.
J Bone Miner Res. 2007;(22) 8:1208-1216
Yuan H, Barnes KR, Weissleder R, Cantley L, Josephson L
Covalent Reactions of Wortmannin under Physiological Conditions.
Chem Biol. 2007;14(3):321-8
Shepherd J, Hilderbrand SA, Waterman P, Heinecke JW, Weissleder R, Libby P
A fluorescent probe for the detection of myeloperoxidase activity in atherosclerosis-associated macrophages.
Chem Biol. 2007;14:1221-31
Kock N, Kasmieh R, Weissleder R, Shah K
Tumor Therapy Mediated by Lentiviral Expression of shBcl-2 and S-TRAIL.
Neoplasia. 2007;9(5):435-42
Harisinghani M, Ross R, Guimaraes A, Weissleder R
Utility of a New Bolus-Injectable Nanoparticle for Clinical Cancer Staging
Neoplasia. 2007;(9)12:1160-1165
Montet X, Figueiredo JL, Alencar H, Ntziachristos V, Mahmood U, Weissleder R.
Tomographic fluorescence imaging of tumor vascular volume in mice.
Radiology. 2007;242 (3):751-758
Upadhyay R, Sheth RA, Weissleder R, Mahmood U
Quantitative Real-time Catheter-based Fluorescence Molecular Imaging in Mice.
Radiology. 2007;245(2):523-31
Alencar H, Funovics MA, Figueiredo J, Sawaya H, Weissleder R, Mahmood U
Colonic Adenocarcinomas: Near-Infrared Microcatheter Imaging of Smart Probes for Early Detection.
Radiology. 2007;244(1):232-8
Taktak S, Sosnovik D, Cima MJ, Weissleder R, Josephson L
Multiparameter Magnetic Relaxation Switch Assays.
Anal Chem. 2007;(79) 23:8863-9
Kim YM, Hilderbrand S, Weissleder R, Tung CH
Sugar sensing based on induced pH changes
Chem Commun. 2007;(22):2299-2301
Hilderbrand S, Weissleder R.
Optimized pH-responsive cyanine fluorochromes for detection of acidic environments
Chem Commun. 2007;(26):2747-9
Bouffard J, Kim Y, Swager TM, Weissleder R, Hilderbrand SA
A Highly Selective Fluorescent Probe for Thiol Bioimaging.
Org Lett. 2007;10 :37-40
Gee MS, Upadhyay R, Bergquist H, Weissleder R, Josephson L, Mahmood U
Multiparameter noninvasive assessment of treatment susceptibility, drug target inhibition and tumor response guides cancer treatment.
Int J Cancer. 2007;(121) 11:2492-2500
Law B, Weissleder R, Tung CH
Protease-Sensitive Fluorescent Nanofibers.
Bioconjug Chem. 2007;(18) 6 ::1701-1704
Nahrendorf M, Badea C, Hedlund LW, Figueiredo JL, Sosnovik DE, Johnson GA, Weissleder R
High Resolution Imaging of Murine Myocardial Infarction With Delayed Enhancement Cine Micro-CT.
Am J Physiol Heart Circ Physiol. 2007;292(6):3172-8
Shtatland T, Guettler D, Kossodo M, Pivovarov M, Weissleder R
PepBank - a database of peptides based on sequence text mining and public peptide data sources.
BMC Bioinformatics. 2007;8(1):280
Ho NH, Weissleder R, Tung CH
A Self-Immolative Reporter For beta-Galactosidase Sensing.
Chembiochem. 2007;8:560-566
Tam JM, Upadhyay R, Pittet MJ, Weissleder R, Mahmood U
Improved in vivo whole-animal detection limits of green fluorescent protein-expressing tumor lines by spectral fluorescence imaging.
Mol Imaging. 2007;6(4):269-76
Montet-Abou K, Montet X, Weissleder R, Josephson L
Cell internalization of magnetic nanoparticles using transfection agents.
Mol Imaging. 2007;(6) 1:1-9
Sheth RA, Upadhyay R, Weissleder R, Mahmood U
Real-time multichannel imaging framework for endoscopy, catheters, and fixed geometry intraoperative systems.
Mol Imaging. 2007;6(3):147-55
Farrar CT, Dai G, Novikov M, Rosenzweig A, Weissleder R, Rosen BR, Sosnovik DE
Impact of field strength and iron oxide nanoparticle concentration on the linearity and diagnostic accuracy of off-resonance imaging.
NMR Biomed. 2007;:ePub
McCarthy JR, Weissleder R
Model Systems for Fluorescence and Singlet Oxygen Quenching by Metalloporphyrins.
ChemMedChem. 2007;2:360-365
McCarthy J, Kelly KA, Sun EY, Weissleder R.
Targeted delivery of multifunctional magnetic nanoparticles
NanoMedicine. 2007;2(2):153-167
Kim Y, Choi Y, Weissleder R, Tung CH
Membrane permeable esterase-activated fluorescent imaging probe.
Bioorg Med Chem Lett. 2007;17(18):5054-7
Korngold EC, Jaffer FA, Weissleder R, Sosnovik DE
Noninvasive imaging of apoptosis in cardiovascular disease.
Heart Fail Rev. 2007;:ePub
Nahrendorf M, Weissleder R
Advances in cardiovascular medicine through molecular imaging.
Radiologe. 2007;47(1):18-24
Grimm J, Kircher MF, Weissleder R
Cell tracking : Principles and applications.
Radiologe. 2007;47(1):25-33
Swirski FK, Berger CR, Figueiredo JL, Mempel TR, von Andrian UH, Pittet MJ, Weissleder R
A near-infrared cell tracker reagent for multiscopic in vivo imaging and quantification of leukocyte immune responses.
PLoS ONE. 2007;2(10):e1075
Kelly KA, Carson J, McCarthy JR, Weissleder R
Novel Peptide Sequence ("IQ-tag") with High Affinity for NIR Fluorochromes Allows Protein and Cell Specific Labeling for In Vivo Imaging.
PLoS ONE. 2007;2:e665
Binstadt BA, Patel PR, Alencar H, Nigrovic PA, Lee DM, Mahmood U, Weissleder R, Mathis D, Benoist C
Particularities of the vasculature can promote the organ specificity of autoimmune attack.
Nat Immunol. 2006;7(3):284-92
Ji H, Li D, Chen L, Shimamura T, Kobayashi S, McNamara K, Mahmood U, Mitchell A, Sun Y, Al-Hashem R, Chirieac LR, Padera R, Bronson RT, Kim W, Janne PA, Shapiro GI, Tenen D, Johnson BE, Weissleder R, Sharpless NE, Wong KK
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies.
Cancer Cell. 2006;9(6):485-95
Rabin O, Manuel Perez J, Grimm J, Wojtkiewicz G, Weissleder R
An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles.
Nat Mater. 2006;5(2):118-22
Mempel T, Pittet M, Khazaie K, Weninger W, Weissleder R, von Boehmer H, von Adrian U.
Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation
Immunity. 2006;25(1):129-41
Zhang M, Alicot EM, Chiu I, Li J, Verna N, Vorup-Jensen T, Kessler B, Shimaoka M, Chan R, Friend D, Mahmood U, Weissleder R, Moore FD, Carroll MC
Identification of the target self-antigens in reperfusion injury.
J Exp Med. 2006;203(1):141-152
Tannous B, Grimm J, Perry K, Chen J, Weissleder R, Breakefield X.
Metabolic Biotinylation of Cell Surface Receptors for in vivo Imaging
Nat Methods. 2006;3(5):391-396
Nahrendorf M, Hu K, Frantz S, Jaffer F, Tung CH, Hiller KH, Voll S, Nordbeck P, Sosnovik D, Gattenlohner S, Novikov M, Dickneite G, Reed G, Jakob P, Rosenzweig A, Bauer W, Weissleder R, Ertl G.
Factor XIII Deficiency Causes Cardiac Rupture, Impairs Wound Healing, and Aggravates Cardiac Remodeling in Mice with Myocardial Infarction
Circulation. 2006;113(9):1196-1202
Deguchi JO, Aikawa M, Tung CH, Aikawa E, Kim DE, Ntziachristos V, Weissleder R, Libby P
Inflammation in Atherosclerosis. Visualizing Matrix Metalloproteinase Action in Macrophages In Vivo.
Circulation. 2006;114:55-62
Nahrendorf M, Jaffer FA, Kelly KA, Sosnovik DE, Aikawa E, Libby P, Weissleder R
Noninvasive Vascular Cell Adhesion Molecule-1 Imaging Identifies Inflammatory Activation of Cells in Atherosclerosis.
Circulation. 2006;114:1504-1511
Jaffer F, Libby P, Weissleder R.
Molecular and Cellular Imaging of Atherosclerosis, Emerging Applications
J Am Coll Cardiol. 2006;47:1328-1338
Quinti L, Weissleder R, Tung CH
A Fluorescent Nanosensor for Apoptotic Cells
Nano Lett. 2006;6 (3):488-490
Swirski FK, Pittet MJ, Kircher MF, Aikawa E, Jaffer FA, Libby P, Weissleder R
Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease.
P Natl Acad Sci U S A. 2006;103(27):10340-5
Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA
Both p16Ink4a and the p19Arf-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse.
P Natl Acad Sci U S A. 2006;103:5947-5952
Fulci G, Breymann L,Gianni D, Kurozomi K, Rhee S, Yu J, Kaur B, Louis D, Weissleder R, Caligiuri M, Chiocca A.
Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses
P Natl Acad Sci U S A. 2006;103:12873-12878
Choi YD, Weissleder R, Tung CH.
Selective antitumor effect of novel protease-mediated photodynamic agent
Cancer Res. 2006;66 (14):7225-7229
Deramaudt TB, Takaoka M, Upadhyay R, Bowser MJ, Porter J, Lee A, Rhoades B, Johnstone CN, Weissleder R, Hingorani SR, Mahmood U, Rustgi AK
N-Cadherin and Keratinocyte Growth Factor Receptor Mediate the Functional Interplay between Ki-RASG12V and p53V143A in Promoting Pancreatic Cell Migration, Invasion, and Tissue Architecture Disruption.
Mol Cell Biol. 2006;26(11):4185-200
McCarthy J, Jaffer F, Weissleder R.
A Macrophage Targeted Theranostic Nanoparticle for Biomedical Applications
Small. 2006;2(8-9):983-987
Sun EY, Weissleder R, Josephson L.
Continuous Analyte Sensing with Magnetic Nanoswitches
Small. 2006;(2) 10:1144-1147
Campanella GS, Grimm J, Manice LA, Colvin RA, Medoff BD, Wojtkiewicz GR, Weissleder R, Luster AD
Oligomerization of CXCL10 Is Necessary for Endothelial Cell Presentation and In Vivo Activity.
J Immunol. 2006;177:6991-8
Vianello F, Papeta N, Chen T, Kraft P, White N, Hart WK, Kircher MF, Swart E, Rhee S, Palu G, Irimia D, Toner M, Weissleder R, Poznansky MC
Murine B16 Melanomas Expressing High Levels of the Chemokine Stromal-Derived Factor-1/CXCL12 Induce Tumor-Specific T Cell Chemorepulsion and Escape from Immune Control.
J Immunol. 2006;176(5):2902-14
Funovics MA, Alencar H, Montet X, Weissleder R, Mahmood U
Simultaneous fluorescence imaging of protease expression and vascularity during murine colonoscopy for colonic lesion characterization.
Gastrointest Endosc. 2006;64(4):589-97
Lamfers ML, Fulci G, Gianni D, Tang Y, Kurozumi K, Kaur B, Moeniralm S, Saeki Y, Carette JE, Weissleder R, Vandertop WP, van Beusechem VW, Dirven CM, Chiocca EA
Cyclophosphamide Increases Transgene Expression Mediated by an Oncolytic Adenovirus in Glioma-Bearing Mice Monitored by Bioluminescence Imaging.
Mol Ther. 2006;4(6):779-88
Yen L, Magnier M, Weissleder R, Stockwell BR, Mulligan RC
Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries.
RNA. 2006;12(5):797-806
Trehin R, Figueiredo JL, Pittet M, Weissleder R, Josephson L, Mahmood U.
Fluorescent Nanoparticle Uptake for Brain Tumor Visualization
Neoplasia. 2006;8(4):302-311
Montet X, Montet-Abou K, Reynolds F, Weissleder R, Josephson L.
Nanoparticle Imaging of Integrins on Tumor Cells
Neoplasia. 2006;8(3):214-222
Newton JR, Kelly KA, Mahmood U, Weissleder R, Deutscher SL
In vivo selection of phage for the optical imaging of PC-3 human prostate carcinoma in mice.
Neoplasia. 2006;8(9):772-80
Kelly KA, Waterman P, Weissleder R.
In vivo imaging of molecularly targeted phage
Neoplasia. 2006;8 (12):1011-1018
Chen JW, Querol Sans M, Bogdanov Jr A, Weissleder R
Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates
Radiology. 2006;240 (2):473-81
Kim DE, Tsuji K, Kim YR, Mueller FJ, Eom HS, Snyder EY, Lo EH, Weissleder R, Schellingerhout D
Neural Stem Cell Transplant Survival in Brains of Mice: Assessing the Effect of Immunity and Ischemia by using Real-time Bioluminescent Imaging.
Radiology. 2006;241(3):822-830
Jaffer FA, Sosnovik DE, Nahrendorf M, Weissleder R
Molecular imaging of myocardial infarction.
J Mol Cell Cardiol. 2006;41:921-933
Yuan H, Luo J, Weissleder R, Cantley L, Josephson L
Wortmannin-C20 Conjugates Generate Wortmannin.
J Med Chem. 2006;49(2):740-747
Montet X, Funovics M, Montet-Abou K, Weissleder R, Josephson L.
Multivalent effects of RGD peptides obtained by nanoparticle display
J Med Chem. 2006;49(20):6087-6093
Galande A, Hilderbrand S, Weissleder R, Tung CH.
Enzyme-targeted fluorescent imaging probes on a multiple antigenic peptide core
J Med Chem. 2006;49(15):4715-20
Law B, Quinti L, Choi YD, Weissleder R, Tung CH
A Mitochondrial Targeted Fusion Peptide Exhibits Remarkable Cytotoxicity
Mol Cancer Ther. 2006;5 (8):1944-1949
Kang HW, Torres D, Wald L, Weissleder R, Bogdanov AA
Targeted imaging of human endothelial-specific marker in a model of adoptive cell transfer.
Lab Invest. 2006;86(6):599-609
Montet X, Yuan H, Weissleder R, Josephson L
Enzyme-based visualization of receptor-ligand binding in tissues.
Lab Invest. 2006;86(5):517-25
Banerjee P, Weissleder R, Bogdanov A
Linear Polyethyleneimine Grafted to a Hyperbranched Poly(ethylene glycol)-like Core: A Copolymer for Gene Delivery.
Bioconjug Chem. 2006;17(1):125-31
Sun EY, Josephson L, Kelly KA, Weissleder R
Development of nanoparticle libraries for biosensing.
Bioconjug Chem. 2006;17(1):109-13
Galande A, Weissleder R, Tung CH.
Fluorescence Probe with a pH-Sensitive Trigger
Bioconjug Chem. 2006;17 (2):255-257
Montet X, Weissleder R, Josephson L.
Imaging pancreatic cancer with a peptide-nanoparticle conjugate targeted to normal pancreas
Bioconjug Chem. 2006;17(4):905-911
Messerli SM, Prabhakar S, Tang Y, Mahmood U, Weissleder R, Bronson R, Martuza R, Rabkin S, Breakefield XO
Treatment of schwannomas with an oncolytic recombinant herpes simplex virus in murine models of neurofibromatosis type 2.
Hum Gene Ther. 2006;17(1):20-30
Law B, Weissleder R, Tung CH
Peptide-based Biomaterials for Protease-Enhanced Drug Delivery
Biomacromolecules. 2006;7(4):1261-1265
Kelly KA, Allport JR, Yu AM, Sinh S, Sage EH, Gerszten RE, Weissleder R
SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration.
J Leukoc Biol. 2006;:ePub
Zacharakis G, Shih H, Ripoll J, Weissleder R, Ntziachristos V
Normalized transillumination of fluorescent proteins in small animals.
Mol Imaging. 2006;5 (2):153-9
Jaffer F, Nahrendorf M, Sosnovik D, Kelly KA, Aikawa E, Weissleder R
Cellular Imaging of Inflammation in Atherosclerosis Using Magnetofluorescent Nanomaterials
Mol Imaging. 2006;(5) 2 :85-92
Kelly KA, Clemons PA, Yu AM, Weissleder R
High throughput identification of phage-derived imaging agents
Mol Imaging. 2006;5(1):24-30
Sun EY, Josephson L, Weissleder R.
Clickable nanoparticles for targeted imaging
Mol Imaging. 2006;(5) 2:122-128
Pande AN, Kohler RH, Aikawa E, Weissleder R, Jaffer FA
Detection of macrophage activity in atherosclerosis in vivo using multichannel, high-resolution laser scanning fluorescence microscopy.
J Biomed Opt. 2006;11(2):21009
Hsiao JK, Law B, Weissleder R, Tung CH
In-vivo imaging of tumor associated urokinase-type plasminogen activator activity.
J Biomed Opt. 2006;11(3):34013
Kelly KA, Nahrendorf M, Yu AM, Reynolds F, Weissleder R
In Vivo Phage Display Selection Yields Atherosclerotic Plaque Targeted Peptides for Imaging.
Mol Imaging Biol. 2006;8(4):201-7
Ho NH, Weissleder R, Tung CH
Development of water-soluble far-red fluorogenic dyes for enzyme sensing
Tetrahedron. 2006;62:578-585
Choi YD, McCarthy J, Weissleder R, Tung CH
Conjugation of a Photosensitizer to an Oligoarginine-based Cell-penetrating Peptide Increases the Efficacy of Photodynamic Therapy
ChemMedChem. 2006;1(4):458-463
Montet X, Rajopadhye M, Weissleder R.
An albumin-activated far-red fluorochrome for in vivo imaging
ChemMedChem. 2006;1(1):66-69
Choi Y, Weissleder R, Tung CH
Protease-mediated phototoxicity of a polylysine-chlorin(E6) conjugate.
ChemMedChem. 2006;1:698-701
Ho NH, Weissleder R, Tung CH
Development of a dual fluorogenic and chromogenic dipeptidyl peptidase IV substrate.
Bioorg Med Chem. 2006;16:2599-2602
Harisinghani MG, Saksena MA, Hahn PF, King B, Kim J, Torabi MT, Weissleder R
Ferumoxtran-10-Enhanced MR Lymphangiography: Does Contrast-Enhanced Imaging Alone Suffice for Accurate Lymph Node Characterization?
Am J Roentgenol. 2006;186(1):144-8
Saksena M, Harisinghani M, Hahn P, Kim J, Saokar A, King B, Weissleder R
Comparison of lymphotropic nanoparticle-enhanced MRI sequences in patients with various primary cancers.
Am J Roentgenol. 2006;187(6):W582-8
Hynynen K, McDannold N, Vykhodtseva N, Raymond S, Weissleder R, Jolesz FA, Sheikov N
Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery.
J Neurosurg. 2006;105:445-54
Pittet M, Swirski F, Reynolds F, Josephson L, Weissleder R.
Labeling of immune cells for in vivo imaging using magnetofluorescent nanoparticles
Nat Protocols. 2006;1(1):73-79
Nahrendorf M, Weissleder R, Ertl G
Does FXIII Deficiency Impair Wound Healing after Myocardial Infarction?
PLoS ONE. 2006;1:e48
Ntziachristos V, Ripoll J, Wang L, Weissleder R
Looking and Listening to light: the evolution of whole-body photonic imaging
Nat Biotechnol. 2005;23:313-320
Weissleder R, Kelly K, Sun E, Shtatland T, Josephson L.
Cell-specific targeting of nanoparticles by multivalent attachment of small molecules
Nat Biotechnol. 2005;23:1418-1423
Turvey SE, Swart E, Denis MC, Mahmood U, Benoist C, Weissleder R, Mathis D.
Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes
J Clin Invest. 2005;115(9):2454-2461
Chen J, Tung CH, Allport JR, Chen S, Weissleder R, Huang PL.
Near-Infrared Fluorescent Imaging of Matrix Metalloproteinase Activity After Myocardial Infarction
Circulation. 2005;111:1800-1805
Kelly KA, Allport JR, Tsourkas A, Shinde-Patil VR, Josephson L, Weissleder R.
Detection of Vascular Adhesion Molecule-1 Expression Using a Novel Multimodal Nanoparticle
Circ Res. 2005;96(3):327-36
McCarthy JR, Perez JM, Brueckner C, Weissleder R
Polymeric Nanoparticle Preparation that Eradicates Tumors.
Nano Lett. 2005;5:2552-6
Chen ML, Pittet MJ, Gorelik L, Flavell RA, Weissleder R, von Boehmer H, Khazaie K.
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-{beta} signals in vivo
P Natl Acad Sci U S A. 2005;102(2):419-24
Grimm J, Kirsch DG, Windsor SD, Kim CF, Santiago PM, Ntziachristos V, Jacks T, Weissleder R.
Use of gene expression profiling to direct in vivo molecular imaging of lung cancer
P Natl Acad Sci U S A. 2005;102(40):14404-14409
Zacharakis G, Kambara H, Shih H, Ripoll J, Grimm J, Saeki Y, Weissleder R, Ntziachristos V.
Volumetric tomography of fluorescent proteins through small animals in vivo
P Natl Acad Sci U S A. 2005;102:18252-18257
Shah K, Bureau E, Kim DE, Yang K, Tang Y, Weissleder R, Breakefield XO.
Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression
Ann Neurol. 2005;57(1):34-41
Montet X, Ntziachristos V, Grimm J, Weissleder R.
Tomographic Fluorescence Mapping of Tumor Targets
Cancer Res. 2005;65 (14):6330-6336
Tang Y, Kim M, Carrasco D, Kung AL, Chin L, Weissleder R.
In vivo assessment of RAS-dependent maintenance of tumor angiogenesis by real-time magnetic resonance imaging
Cancer Res. 2005;65(18):8324-30
Kim YR, Yudina A, Figueiredo J, Reichardt W, Hu-Lowe D, Petrovsky A, Kang HW, Torres D, Mahmood U, Weissleder R, Bogdanov AA Jr.
Detection of Early Antiangiogenic Effects in Human Colon Adenocarcinoma Xenografts: In vivo Changes of Tumor Blood Volume in Response to Experimental VEGFR Tyrosine Kinase Inhibitor
Cancer Res. 2005;65(20):9253-60
Kelloff GJ, Krohn KA, Larson SM, Weissleder R, Mankoff DA, Hoffman JM, Link JM, Guyton KZ, Eckelman WC, Scher HI, O
The progress and promise of molecular imaging probes in oncologic drug development.
Clin Cancer Res. 2005;11(22):7967-85
Tannous BA, Kim DE, Fernandez JL, Weissleder R, Breakefield XO.
Codon-optimized gaussia luciferase cDNA for Mammalian gene expression in culture and in vivo
Mol Ther. 2005;11(3):435-43
Shah K, Tung CH, Breakefield X, Weissleder R.
In vivo imaging of S-TRAIL-mediated tumor regression and apoptosis
Mol Ther. 2005;11 (6):926-931
Alencar H, Mahmood U, Kawano Y, Hirata T, Weissleder R
Novel Multiwavelength Microscopic Scanner for Mouse Imaging.
Neoplasia. 2005;7(11):977-983
Funovics M, Montet X, Reynolds F, Weissleder R, Josephson L.
Nanoparticles for the Optical Imaging of Tumor E-selectin
Neoplasia. 2005;7(10):904-11
Shinde Patil VR, Friedrich EB, Wolley AE, Gerszten RE, Allport JR, Weissleder R.
Bone Marrow-Derived lin(-)c-kit(+)Sca-1(+) Stem Cells Do Not Contribute to Vasculogenesis in Lewis Lung Carcinoma
Neoplasia. 2005;7(3):234-40
Reichardt W, Hu-Lowe D, Torres D, Weissleder R, Bogdanov A Jr.
Imaging of VEGF receptor kinase inhibitor-induced antiangiogenic effects in drug-resistant human adenocarcinoma model
Neoplasia. 2005;7(9):847-53
Tsourkas A, Newton G, Perez JM, Basilion J, Weissleder R.
Detection of Peroxidase-Mediated Dityrosine Formation with Enhanced Yellow Fluorescent Protein
Anal Chem. 2005;77:2862-2867
Kim DE, Jaffer FA, Weissleder R, Tung CH, Schellingerhout D.
Near-infrared fluorescent imaging of cerebral thrombi and blood-brain barrier disruption in a mouse model of cerebral venous sinus thrombosis
J Cereb Blood F Met. 2005;25(2):226-33
Querol M, Chen JW, Weissleder R, Bogdanov A Jr.
DTPA-bisamide-Based MR Sensor Agents for Peroxidase Imaging
Org Lett. 2005;7(9):1719-22
Alencar H, King R, Funovics M, Stout C, Weissleder R, Mahmood U.
A novel mouse model for segmental orthotopic colon cancer
Int J Cancer. 2005;117(3):335-9
Figueiredo JL, Alencar H, Weissleder R, Mahmood U
Near infrared thoracoscopy of tumoral protease activity for improved detection of peripheral lung cancer.
Int J Cancer. 2005;118(11):2672-7
Tsourkas A, Shinde-Patil VR, Kelly KA, Patel P, Wolley A, Allport JR, Weissleder R.
In Vivo Imaging of Activated Endothelium Using an Anti-VCAM-1 Magneto optical Probe
Bioconjug Chem. 2005;(3):576-581
Yuan H, Luo J, Field S, Weissleder R, Cantley L, Josephson L.
Synthesis and Activity of C11-Modified Wortmannin Probes for P13 Kinase
Bioconjug Chem. 2005;(3):669-675
Hilderbrand SA, Kelly KA, Weissleder R, Tung CH.
Monofunctional near-infrared fluorochromes for imaging applications
Bioconjug Chem. 2005;16(5):1275-81
Reynolds F, Weissleder R, Josephson L.
Protamine as an efficient membrane-translocating Peptide
Bioconjug Chem. 2005;16(5):1240-5
Messerli SM, Prabhakar S, Tang Y, Mahmood U, Weissleder R, Bronson R, Martuza R, Rabkin S, Breakefield XO
Treatment of Schwannomas with an Oncolytic Recombinant Herpes Simplex Virus in Murine Models of Neurofibromatosis Type 2.
Hum Gene Ther. 2005;17(1):20-30
Brown AB, Mahmood U, Cortes ML, Tang Y, Dai G, Stemmer-Rachamimov A, Prabhakar S, Leishear K, Onda H, Kwiatkowski D, Weissleder R, Breakefield X
Magnetic resonance imaging and characterization of spontaneous lesions in a transgenic mouse model of tuberous sclerosis as a model for endothelial cell-based transgene delivery.
Hum Gene Ther. 2005;16:1367-76
Shih HA, Harisinghani M, Zietman AL, Wolfgang JA, Saksena M, Weissleder R.
Mapping of nodal disease in locally advanced prostate cancer: Rethinking the clinical target volume for pelvic nodal irradiation based on vascular rather than bony anatomy
Int J Radiat Oncol. 2005;63(4):1262-9
Bremer C, Ntziachristos V, Weitkamp B, Theilmeier G, Heindel W, Weissleder R.
Optical Imaging of Spontaneous Breast Tumors Using Protease Sensing
Invest Radiol. 2005;(6):321-327
Choi HK, Yessayan D, Choi HJ, Schellenberger E, Bogdanov A, Josephson L, Weissleder R, Ntziachristos V.
Quantitative analysis of chemotherapeutic effects in tumors using in vivo staining and correlative histology
Cell Oncol. 2005;27(3):183-90
Chen WT, Mahmood U, Weissleder R, Tung CH
Arthritis imaging using a near-infrared fluorescence folate-targeted probe
Arthritis Res Ther. 2005;7:R310-R317
Shah K, Weissleder R
Molecular Optical Imaging: Applications Leading to the Development of Present Day Therapeutics
NeuroRx. 2005;2:215-225
Tung CH, Quinti L, Jaffer F, Weissleder R
A Branched Fluorescent Peptide Probe for Imaging of Activated Platelets
Mol Pharmacol. 2005;2:92-95
Koch AM, Reynolds F, Merkle HP, Weissleder R, Josephson L.
Transport Of Surface-Modified Nanoparticles Through Cell Monolayers
Chembiochem. 2005;6(2):337-345
Law B, Weissleder R, Tung CH.
Mechanism-Based Fluorescent Reporter for Protein Kinase A Detection
Chembiochem. 2005;6(8):1361-1367
Chen WT, Khazaie K, Zhang G, Weissleder R, Tung CH
Detection of dysplastic intestinal adenomas using a fluorescent folate imaging probe
Mol Imaging. 2005;4 (1):67-74
Wunder A, Schellenberger E, Mahmood U, Bogdanov A Jr, Muller-Ladner U, Weissleder R, Josephson L.
Methotrexate-induced accumulation of fluorescent annexin v in collagen-induced arthritis
Mol Imaging. 2005;4(1):1-6
Montet-Abou K, Montet X, Weissleder R, Josephson L.
Transfection agent induced nanoparticle cell loading
Mol Imaging. 2005;4(3):165-71
Pivovarov M, Bhandary G, Mahmood U, Zahlmann G, Naraghi M, Weissleder R
MIPortal: A High Capacity Server for Molecular Imaging Research.
Mol Imaging. 2005;4(4):425-31
Gillies R, Hoffman J, Lam K, Menkens A, Piwnica-Worms D, Sullivan D, Weissleder R.
Meeting Report: High-Throughput Technologies for In Vivo Imaging Agents
Mol Imaging. 2005;4:1-6
Zacharakis G, Ripoll J, Weissleder R, Ntziachristos V.
Fluorescent protein tomography scanner for small animal imaging
IEEE T Med Imaging. 2005;24(7):878-85
Galande A, Weissleder R, Tung CH.
An Effective Method of On-Resin Disulfide Bond Formation in Peptides
J Comb Chem. 2005;7:174-177
Sosnovik DE, Schellenberger EA, Nahrendorf M, Novikov MS, Matsui T, Dai G, Reynolds F, Grazette L, Rosenzweig A, Weissleder R, Josephson L.
Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle
Magn Reson Med. 2005;54(3):718-724
Graves EE, Yessayan D, Turner G, Weissleder R, Ntziachristos V.
Validation of in vivo fluorochrome concentrations measured using fluorescence molecular tomography
J Biomed Opt. 2005;10(4):44019
Law B, Hsiao JK, Bugge TH, Weissleder R, Tung CH.
Optical zymography for specific detection of urokinase plasminogen activator activity in biological samples
Anal Biochem. 2005;338(1):151-158
Querol Sans M, Chen JW, Weissleder R, Bogdanov AA
Myeloperoxidase Activity Imaging Using (67)Ga Labeled Substrate.
Mol Imaging Biol. 2005;:1-8
Reynolds F, O'loughlin T, Weissleder R, Josephson L.
Method of Determining Nanoparticle Core Weight
Anal Bioanal Chem. 2005;77(3):814-817
Zhu B, Jaffer F, Nztiachristos V, Weissleder R
Development of a near infrared fluorescence catheter: operating characteristics and feasibility for atherosclerotic plaque detection
J Phys D Appl Phys. 2005;38:2701-2707
Harisinghani MG, Saksena M, Ross RW, Tabatabaei S, Dahl D, McDougal S, Weissleder R
A pilot study of lymphotrophic nanoparticle-enhanced magnetic resonance imaging technique in early stage testicular cancer: a new method for noninvasive lymph node evaluation.
Urology. 2005;66(5):1066-71
Kim CF, Jackson EL, Kirsch DG, Grimm J, Shaw AT, Lane K, Kissil J, Olive KP, Sweet-Cordero A, Weissleder R, Jacks T
Mouse Models of Human Non-Small-Cell Lung Cancer: Raising the Bar.
Cold Spring Harb Symp Quant Biol. 2005;70:241-250
Bogdanov AA Jr, Chen JW, Kang HW, Weissleder R.
Magnetic resonance signal amplification probes
Ernst Schering Res Found Workshop. 2005;49:147-57
Sosnovik D, Weissleder R
Magnetic resonance and fluorescence based molecular imaging technologies.
Prog Drug Res. 2005;62:83-115
Jaffer FA, Tung CH, Wykrzykowska JJ, Ho NH, Houng AK, Reed GL, Weissleder R
Molecular Imaging of Factor XIIIa Activity in Thrombosis Using a Novel, Near-Infrared Fluorescent Contrast Agent That Covalently Links to Thrombi.
Circulation. 2004;110(2):170-6
Harisinghani MG, Weissleder R
Sensitive, noninvasive detection of lymph node metastases.
PLoS Med. 2004;1(3):e66
Tsourkas A, Hofstetter O, Hofstetter H, Weissleder R, Josephson L
Magnetic Relaxation Switch Immunosensors Detect Enantiomeric Impurities
Angew Chem Int Edit. 2004;43(18):2395-2399
Jaffer FA, Weissleder R
Seeing within: molecular imaging of the cardiovascular system
Circ Res. 2004;94(4):433-45
Perez JM, Simeone FJ, Tsourkas A, Josephson L, Weissleder R
Peroxidase substrate nanosensors for MR imaging
Nano Lett. 2004;4:119-122
Ntziachristos V, Schellenberger EA, Ripoll J, Yessayan D, Graves E, Bogdanov A Jr, Josephson L, Weissleder R
Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate.
P Natl Acad Sci U S A. 2004;101(33):12294-9
Denis MC, Mahmood U, Benoist C, Mathis D, Weissleder R
Imaging inflammation of the pancreatic islets in type 1 diabetes.
P Natl Acad Sci U S A. 2004;101(34):12634-9
Shah K, Tung CH, Yang K, Weissleder R, Breakefield XO
Inducible release of TRAIL fusion proteins from a proapoptotic form for tumor therapy
Cancer Res. 2004;64(9):3236-42
Tung CH, Zeng Q, Shah K, Kim DE, Schellingerhout D, Weissleder R
In Vivo Imaging of ?-Galactosidase Activity Using Far Red Fluorescent Switch
Cancer Res. 2004;64:1579-1583
Kelly K, Alencar H, Funovics M, Mahmood U, Weissleder R
Detection of invasive colon cancer using a novel, targeted, library-derived fluorescent peptide.
Cancer Res. 2004;64(17):6247-51
Gondi CS, Lakka SS, Yanamandra N, Olivero WC, Dinh DH, Gujrati M, Tung CH, Weissleder R, Rao JS
Adenovirus-mediated expression of antisense urokinase plasminogen activator receptor and antisense cathepsin B inhibits tumor growth, invasion, and angiogenesis in gliomas.
Cancer Res. 2004;64(12):4069-77
Grimm J, Perez JM, Josephson L, Weissleder R
Novel nanosensors for rapid analysis of telomerase activity
Cancer Res. 2004;64:639-43
Shah K, Tung CH, Chang CH, Slootweg E, O'Loughlin T, Breakefield XO, Weissleder R
In vivo imaging of HIV protease activity in amplicon vector-transduced gliomas
Cancer Res. 2004;64:273-8
Wunder A, Tung CH, Muller-Ladner U, Weissleder R, Mahmood U
In vivo imaging of protease activity in arthritis: a novel approach for monitoring treatment response.
Arth Rheum. 2004;50(8):2459-65
Zhao M, Weissleder R
Intracellular cargo delivery using tat peptide and derivatives
Med Res Rev. 2004;24:1-12
Kim DE, Schellingerhout D, Ishii K, Shah K, Weissleder R
Imaging of Stem Cell Recruitment to Ischemic Infarcts in a Murine Model
Stroke. 2004;35:952-7
Law B, Curino A, Bugge TH, Weissleder R, Tung CH
Design, synthesis, and characterization of urokinase plasminogen-activator-sensitive near-infrared reporter.
Chem Biol. 2004;11(1):99-106
Messerli SM, Prabhakar S, Tang Y, Shah K, Cortes ML, Murthy V, Weissleder R, Breakefield XO, Tung CH
A novel method for imaging apoptosis using a caspase-1 near-infrared fluorescent probe.
Neoplasia. 2004;6(2):95-105
Funovics MA, Weissleder R, Mahmood U
Catheter-based in vivo imaging of enzyme activity and gene expression: feasibility study in mice.
Radiology. 2004;231(3):659-66
Shah K, Jacobs A, Breakefield XO, Weissleder R
Molecular imaging of gene therapy for cancer
Gene Ther. 2004;11(15):1175-87
Graves EE, Weissleder R, Ntziachristos V
Fluorescence molecular imaging of small animal tumor models.
Curr Mol Med. 2004;4(4):419-30
Schellenberger EA, Sosnovik D, Weissleder R, Josephson L
Magneto/Optical annexin v, a multimodal protein.
Bioconjug Chem. 2004;15(5):1062-7
Metelev V, Weissleder R, Bogdanov A Jr
Synthesis and Properties of Fluorescent NF-kappaB-Recognizing Hairpin Oligodeoxyribonucleotide Decoys.
Bioconjug Chem. 2004;15(6):1481-1487
Banerjee P, Reichardt W, Weissleder R, Bogdanov A Jr
Novel hyperbranched dendron for gene transfer in vitro and in vivo.
Bioconjug Chem. 2004;15(5):960-8
Kircher MF, Weissleder R, Josephson L
A dual fluorochrome probe for imaging proteases
Bioconjug Chem. 2004;15:242-8
Pham W, Choi Y, Weissleder R, Tung CH
Developing a Peptide-Based Near-Infrared Molecular Probe for Protease Sensing.
Bioconjug Chem. 2004;15(6):1403-1407
Pham W, Kircher MF, Weissleder R, Tung CH
Enhancing membrane permeability by Fatty acylation of oligoarginine peptides.
Chembiochem. 2004;5(8):1148-51
Perez JM, Josephson L, Weissleder R
Use of magnetic nanoparticles as nanosensors to probe for molecular interactions
Chembiochem. 2004;5:261-4
Schellenberger EA, Reynolds F, Weissleder R, Josephson L
Surface-functionalized nanoparticle library yields probes for apoptotic cells
Chembiochem. 2004;5:275-9
Schellenberger EA, Weissleder R, Josephson L
Optimal modification of annexin v with fluorescent dyes
Chembiochem. 2004;5:271-4
Chen WT, Tung CH, Weissleder R
Imaging reactive oxygen species in arthritis.
Mol Imaging. 2004;3(3):159-62
Chen JW, Pham W, Weissleder R, Bogdanov A Jr
Human myeloperoxidase: A potential target for molecular MR imaging in atherosclerosis.
Magn Reson Med. 2004;52(5):1021-8
Kim YR, Savellano MD, Savellano DH, Weissleder R, Bogdanov A Jr
Measurement of tumor interstitial volume fraction: Method and implication for drug delivery
Magn Reson Med. 2004;52(3):485-94
Kelly KA, Reynolds F, Weissleder R, Josephson L
Fluorescein isothiocyanate-hapten immunoassay for determination of peptide-cell interactions.
Anal Biochem. 2004;330(2):181-5
Allport JR, Shinde Patil VR, Weissleder R
Murine Neuronal Progenitor Cells are Preferentially Recruited to Tumor Vasculature via alpha(4)-integrin and SDF-1alpha-Dependent Mechanisms.
Cancer Biol Ther. 2004;3(9):838-44
Graves EE, Culver JP, Ripoll J, Weissleder R, Ntziachristos V
Singular-value analysis and optimization of experimental parameters in fluorescence molecular tomography
J Opt Soc Am A Opt Image Sci Vis. 2004;21(2):231-41
Tsourkas A, Weissleder R
Illuminating the dynamics of intracellular activity with
Mech Chem Biosyst. 2004;1:133-45
Harisinghani MG, Barentsz J, Hahn PF, Deserno WM, Tabatabaei S, van de Kaa CH, de la Rosette J, Weissleder R
Noninvasive detection of clinically occult lymph-node metastases in prostate cancer
N Engl J Med. 2003;348:2491-9
Rudin M, Weissleder R
Molecular imaging in drug discovery and development
Nat Rev Drug Discov. 2003;2:123-31
Zhao M, Josephson L, Tang Y, Weissleder R
Magnetic sensors for protease assays
Angew Chem Int Edit. 2003;42:1375-8
Tung CH, Weissleder R
Arginine containing peptides as delivery vectors
Adv Drug Deliv Rev. 2003;55:281-94
Perez JM, Simeone FJ, Saeki Y, Josephson L, Weissleder R
Viral-induced self-assembly of magnetic nanoparticles allows the detection of viral particles in biological media
J Am Chem Soc. 2003;125:10192-3
Kircher MF, Allport, JR, Graves EE, Love V, Josephson L, Lichtman AH, Weissleder R
In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumors
Cancer Res. 2003;63:6838-46
Petrovsky A, Schellenberger E, Josephson L, Weissleder R, Bogdanov A Jr
Near-infrared fluorescent imaging of tumor apoptosis
Cancer Res. 2003;63:1936-42
Kircher MF, Mahmood U, King RS, Weissleder R, Josephson L
A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation
Cancer Res. 2003;63:8122-5
Shah K, Tang Y, Breakefield X, Weissleder R
Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo
Oncogene. 2003;22:6865-72
Hogemann-Savellano D, Bos E, Blondet C, Sato F, Abe T, Josephson L, Weissleder R, Gaudet J, Sgroi D, Peters PJ, Basilion JP.
The transferrin receptor: a potential molecular imaging marker for human cancer.
Neoplasia. 2003;5(6):495-506
Allport JR, Weissleder R
Murine Lewis lung carcinoma-derived endothelium expresses markers of endothelial activation and requires tumor-specific extracellular matrix in vitro
Neoplasia. 2003;5:205-17
Schellenberger EA, Bogdanov A Jr, Petrovsky A, Ntziachristos V, Weissleder R, Josephson L
Optical imaging of apoptosis as a biomarker of tumor response to chemotherapy
Neoplasia. 2003;5:187-92
Bremer C, Mustafa M, Bogdanov A Jr, Ntziachristos V, Petrovsky A, Weissleder R
Steady-state blood volume measurements in experimental tumors with different angiogenic burdens a study in mice
Radiology. 2003;226:214-20
Mahmood U, Weissleder R
Near-infrared optical imaging of proteases in cancer
Mol Cancer Ther. 2003;2:489-96
Pham W, Lai WF, Weissleder R, Tung CH
High efficiency synthesis of a bioconjugatable near-infrared fluorochrome
Bioconjug Chem. 2003;14:1048-51
Moon, WK, Lin Y, O'Loughlin T, Tang Y, Kim DE, Weissleder R, Tung CH
Enhanced tumor detection using a folate receptor-targeted near-infrared fluorochrome conjugate
Bioconjug Chem. 2003;14:539-45
Koch AM, Reynolds F, Kircher MF, Merkle HP, Weissleder R, Josephson L
Uptake and metabolism of a dual fluorochrome Tat-nanoparticle in HeLa cells
Bioconjug Chem. 2003;14:1115-21
Tang Y, Shah K, Messerli SM, Snyder E, Breakefield X, Weissleder R
In vivo tracking of neural progenitor cell migration to glioblastomas
Hum Gene Ther. 2003;14:1247-54
Simonova M, Shtanko O, Sergeyev N, Weissleder R, Bogdanov A Jr
Engineering of technetium-99m-binding artificial receptors for imaging gene expression
J Gene Med. 2003;5:1056-66
Tung CH, Ho NH, Zeng Q, Tang Y, Jaffer FA, Reed GL, Weissleder R
Novel Factor XIII Probes for Blood Coagulation Imaging
Chembiochem. 2003;4:897-899
Moffat BA, Reddy GR, McConville P, Hall DE, Chenevert TL, Kopelman RR, Philbert M, Weissleder R, Rehemtulla A, Ross BD
A novel polyacrylamide magnetic nanoparticle contrast agent for molecular imaging using MRI
Mol Imaging. 2003;2:324-32
Josephson L, Mahmood U, Wunderbaldinger P, Tang Y, Weissleder R
Pan and sentinel lymph node visualization using a near-infrared fluorescent probe
Mol Imaging. 2003;2:18-23
Lin Y, Weissleder R, Tung CH
Synthesis and properties of sulfhydryl-reactive near-infrared cyanine fluorochromes for fluorescence imaging
Mol Imaging. 2003;2:87-92
Funovics MA, Alencar H, Su HS, Khazaie K, Weissleder R, Mahmood U
Miniaturized multichannel near infrared endoscope for mouse imaging
Mol Imaging. 2003;2:350-7
Graves EE, Ripoll J, Weissleder R, Ntziachristos V
A submillimeter resolution fluorescence molecular imaging system for small animal imaging
Med Phys. 2003;30:901-11
Funovics M, Weissleder R, Tung CH
Protease sensors for bioimaging
Anal Bioanal Chem. 2003;377:956-63
Ntziachristos V, Bremer C, Weissleder R
Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging
Eur J Radiol. 2003;13:195-208
Bremer C, Ntziachristos V, Weissleder R
Optical-based molecular imaging: contrast agents and potential medical applications
Eur J Radiol. 2003;13:231-43
Yip S, Aboody KS, Burns M, Imitola J, Boockvar JA, Allport J, Park KI, Teng YD, Lachyankar M, McIntosh T, O'Rourke DM, Khoury S, Weissleder R, Black PM, Weiss W, Snyder EY
Neural stem cell biology may be well suited for improving brain tumor therapies
Cancer J. 2003;9:189-204
Ntziachristos V, Tung CH, Bremer C, Weissleder R
Fluorescence molecular tomography resolves protease activity in vivo
Nat Med. 2002;8: |
