Ralph Weissleder, MD, PhD
Professor, Harvard Medical School Director, Center for Molecular Imaging Research Director, Center for Systems Biology Phone: 617-726-8226 Email: rweissleder@mgh.harvard.edu My primary research interests lie in the field of in vivo molecular imaging. Specific research interests over the last 10 years have included the development of novel molecular probes for MR imaging, methods to image cell trafficking and homing, imaging of gene expression in vivo and development of novel imaging technologies, in particular different magnetic resonance and optical imaging methods. These basic research interests go hand-in hand with my clinical interests in interventional and oncologic imaging. Specific examples of translational research have included the development of novel magnetic nanoparticles for MR imaging; the development of enzyme activatable probes for the detection of early cancers by minimally invasive techniques such as laparoscopy; and clinical testing of long circulating polymers for angiogenesis imaging. Molecular libraries and screens: One of the current areas of interest is the creation and use of entire libraries of imaging agents and their screening to identify hits for molecular targets of interest. Using this approach we have identified unique molecules and nanomaterials with specificity for activated and resting macrophages, subsets of endothelial cells and specific tumor cells. Nanomaterials: Another area of interest is the exploration of novel nanomaterials to develop novel diagnostic and therapeutic agents. We have developed a series of new nanomaterials for specific applications in cancer and cardiovascular disease. Stem cells: Another long standing research interest has been the imaging and tracking of individual cell populations in vivo especially stem cells. While we developed methods of superparamagnetic cell labeling over 10 years ago, it has not been until very recently that the use of membrane translocation signals has afforded the much required higher loading capacity of cells. Having the necessary tools at hand, we are now interested in exploring how the localization and retrieval of cell populations in vivo will enable detailed analysis of specific stem cell and organ interactions critical for advancing the therapeutic use of stem cells. Another area of interest is the identification of new affinity ligands for different stem cell types to allow their visualization in vivo. Publications Swirski* FK, Nahrendorf* M, Etzrodt M, Wildgruber M, Cortez-Retamozo V, Panizzi P, Figueiredo JL, Kohler RH, Chudnovskiy A, Waterman P, Aikawa E, Mempel TR, Libby P, Weissleder R, Pittet MJ
Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites
Science. 2009;325 (5940):612-6 - PMID: 19644120
Christen T*, Nahrendorf M*, Wildgruber M, Swirski FK, Aikawa E, Waterman P, Shimizu K, Weissleder R, Libby P
Molecular Imaging of Innate Immune Cell Function in Transplant Rejection.
Circulation. 2009;119(14):1925-32 - PMID: 19332470 - PMCID: PMC2676889
Aikawa E, Aikawa M, Libby P, Figueiredo JL, Rusanescu G, Iwamoto Y, Fukuda D, Kohler RH, Shi GP, Jaffer FA, Weissleder R
Arterial and Aortic Valve Calcification Abolished by Elastolytic Cathepsin S Deficiency in Chronic Renal Disease.
Circulation. 2009;119(13):1785-94 - PMID: 19307473 - PMCID: PMC2717745
Ronald JA*, Chen JW*, Chen Y, Hamilton AM, Rodriguez E, Reynolds F, Hegele RA, Rogers KA, Querol M, Bogdanov A, Weissleder R, Rutt BK
Enzyme-Sensitive Magnetic Resonance Imaging Targeting Myeloperoxidase Identifies Active Inflammation in Experimental Rabbit Atherosclerotic Plaques.
Circulation. 2009;120(7):592-9 - PMID: 19652086 - PMCID: PMC2736635
Lee H*, Yoon TJ*, Weissleder R
Ultrasensitive Detection of Bacteria Using Core-Shell Nanoparticles and an NMR-Filter System.
Angew Chem Int Edit. 2009;48(31):5657-60 - PMID: 19554581 - PMCID: PMC2453069
Devaraj NK, Upadhyay R, Haun JB, Hilderbrand SA, Weissleder R
Fast and Sensitive Pretargeted Labeling of Cancer Cells through a Tetrazine/trans-Cyclooctene Cycloaddition.
Angew Chem Int Edit. 2009;48(38):7013-6 - PMID: 19697389
Sasportas LS, Kasmieh R, Wakimoto H, Hingtgen S, van de Water JA, Mohapatra G, Figueiredo JL, Martuza RL, Weissleder R, Shah K
Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for cancer therapy.
P Natl Acad Sci U S A. 2009;106(12):4822-7 - PMID: 19264968 - PMCID: PMC2660771
Lee H*, Yoon TJ*, Figueiredo JL, Swirski FK, Weissleder R
Rapid detection and profiling of cancer cells in fine-needle aspirates.
P Natl Acad Sci U S A. 2009;106 (30):12459-12464 - PMID: 19620715 - PMCID: PMC2718371
Zhu H, Acquaviva J, Ramachandran P, Boskovitz A, Woolfenden S, Pfannl R, Bronson RT, Chen JW, Weissleder R, Housman DE, Charest A
Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis.
P Natl Acad Sci U S A. 2009;106(8):2712-6 - PMID: 19196966 - PMCID: PMC2650331
Panizzi P, Nahrendorf M, Wildgruber M, Waterman P, Figueiredo JL, Aikawa E, McCarthy J, Weissleder R, Hilderbrand SA
Oxazine Conjugated Nanoparticle Detects in Vivo Hypochlorous Acid and Peroxynitrite Generation.
J Am Chem Soc. 2009;131(43):15739-44 - PMID: 19817443 - PMCID: PMC2773134
Stangenberg L, Ellson C, Cortez-Retamozo V, Ortiz-Lopez A, Yuan H, Blois J, Smith RA, Yaffe MB, Weissleder R, Benoist C, Mathis D, Josephson L, Mahmood U
Abrogation of antibody-induced arthritis in mice by a self-activating viridin prodrug and association with impaired neutrophil and endothelial cell function.
Arthritis Rheum. 2009;60:2314-2324 - PMID: 19644878
Hilderbrand SA, Weissleder R
Near-infrared fluorescence: application to in vivo molecular imaging.
Curr Opin Chem Bio. 2009;14:1-9 - PMID: 19879798
Swirski FK, Weissleder R, Pittet MJ
Heterogeneous In Vivo Behavior of Monocyte Subsets in Atherosclerosis.
Jaffer FA, Libby P, Weissleder R
Optical and Multimodality Molecular Imaging. Insights Into Atherosclerosis.
Arterioscler Thromb Vasc Biol. 2009;29(7):1017-24 - PMID: 19359659 - PMCID: PMC2733228
Nahrendorf M, Waterman P, Thurber G, Groves K, Rajopadhye M, Panizzi P, Marinelli B, Aikawa E, Pittet MJ, Swirski FK, Weissleder R
Hybrid In Vivo FMT-CT Imaging of Protease Activity in Atherosclerosis With Customized Nanosensors.
Arterioscler Thromb Vasc Biol. 2009;29(10):1444-51 - PMID: 19608968 - PMCID: PMC2746251
Leimgruber A, Berger C, Cortez-Retamozo V, Etzrodt M, Newton A, Waterman P, Figueiredo JL, Kohler R, Elpek N, Mempel TR, Swirski FK, Nahrendorf M, Weissleder R, Pittet MJ
Behavior of endogenous tumor-associated macrophages assessed in vivo using a functionalized nanoparticle
McCann CM, Waterman P, Figueiredo JL, Aikawa E, Weissleder R, Chen JW
Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy.
Neuroimage. 2009;45(2):360-9 - PMID: 19154791 - PMCID: PMC2707831
Koh I, Hong R, Weissleder R, Josephson L
Nanoparticle-Target Interactions Parallel Antibody-Protein Interactions.
Anal Chem. 2009;81(9):3618-22 - PMID: 19323458 - PMCID: PMC2690647
Hilderbrand SA, Shao F, Salthouse C, Mahmood U, Weissleder R
Upconverting luminescent nanomaterials: application to in vivo bioimaging.
Chem Commun. 2009;28:4188-90 - PMID: 19585016 - PMCID: PMC2748243
Garanger E, Hilderbrand SA, Blois JT, Sosnovik DE, Weissleder R, Josephson L
A DNA-binding Gd chelate for the detection of cell death by MRI.
Chem Commun. 2009;(29):4444-6 - PMID: 19597620 - PMCID: PMC2754278
Daniel KD, Kim GY, Vassiliou CC, Galindo M, Guimaraes AR, Weissleder R, Charest A, Langer R, Cima MJ
Implantable diagnostic device for cancer monitoring.
Biosens Bioelectron. 2009;24(11):3252-7 - PMID: 19442510 - PMCID: PMC2738970
Tannous BA, Christensen AP, Pike L, Wurdinger T, Perry KF, Saydam O, Jacobs AH, Garcia-Anoveros J, Weissleder R, Sena-Esteves M, Corey DP, Breakefield XO
Mutant Sodium Channel for Tumor Therapy.
Mol Cancer Ther. 2009;17(5):810-9 - PMID: 19259066 - PMCID: PMC2751883
Hardcastle J, Kurozumi K, Dmitrieva N, Sayers MP, Ahmad S, Waterman P, Weissleder R, Chiocca EA, Kaur B
Enhanced Antitumor Efficacy of Vasculostatin (Vstat120) Expressing Oncolytic HSV-1.
Mol Cancer Ther. 2009;:ePub - PMID: 19844198
Smith A, Blois J, Yuan H, Aikawa E, Ellson C, Figueiredo JL, Weissleder R, Kohler R, Yaffe MB, Cantley LC, Josephson L
The antiproliferative cytostatic effects of a self-activating viridin prodrug.
Mol Cancer Ther. 2009;8(6):1666-1675 - PMID: 19509266 - PMCID: PMC2740925
Hjortnaes J, Gottlieb D, Figueiredo JL, Melero-Martin J, Kohler RH, Bischoff J, Weissleder R, Mayer J, Aikawa E
Intravital Molecular Imaging of Small-Diameter Tissue-Engineered Vascular Grafts: A Feasibility Study.
Tissue Eng. 2009;:ePub - PMID: 19751103
Smith RA, Yuan H, Weissleder R, Cantley LC, Josephson L
A Wortmannin-Cetuximab as a Double Drug.
Bioconjugate Chem. 2009;20 :2185-2189 - PMID: 19883074
Garanger E, Weissleder R, Josephson L
A Multifunctional Single-Attachment-Point Reagent for Controlled Protein Biotinylation.
Bioconjugate Chem. 2009;20(1):170-173 - PMID: 19072220 - PMCID: PMC2692913
Devaraj NK*, Keliher EJ*, Thurber GM, Nahrendorf M, Weissleder R
(18)F Labeled Nanoparticles for in Vivo PET-CT Imaging.
Bioconjugate Chem. 2009;20(2):397-401 - PMID: 19138113 - PMCID: PMC2644737
McCarthy JR, Patel P, Botnaru I, Haghayeghi P, Weissleder R, Jaffer FA
Multimodal Nanoagents for the Detection of Intravascular Thrombi.
Bioconjugate Chem. 2009;20(6):1251-5 - PMID: 19456115 - PMCID: PMC2733224
Yoon SS, Stangenberg L, Lee YJ, Rothrock C, Dreyfuss JM, Baek KH, Waterman PR, Nielsen GP, Weissleder R, Mahmood U, Park PJ, Jacks T, Dodd RD, Fisher CJ, Ryeom S, Kirsch DG
Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma.
Int J Radiat Oncol Biol Phys. 2009;74(4):1207-16 - PMID: 19545786 - PMCID: PMC2733223
Kozloff KM, Quinti L, Patntirapong S, Hauschka PV, Tung CH, Weissleder R, Mahmood U
Non-invasive optical detection of cathepsin K-mediated fluorescence reveals osteoclast activity in vitro and in vivo.
Bone. 2009;44:190-198 - PMID: 19007918 - PMCID: PMC2656637
Bhaumik J, Weissleder R, McCarthy JR
Synthesis and Photophysical Properties of Sulfonamidophenyl Porphyrins as Models for Activatable Photosensitizers.
J Org Chem. 2009;:ePub - PMID: 19610602
Duchrow T, Shtatland T, Guettler D, Pivovarov M, Kramer S, Weissleder R
Enhancing navigation in biomedical databases by community voting and database-driven text classification.
BMC Bioinformatics. 2009;10(1):317 - PMID: 19799796 - PMCID: PMC2768718
Vinegoni C, Razansky D, Hilderbrand SA, Shao F, Ntziachristos V, Weissleder R
Transillumination fluorescence imaging in mice using biocompatible upconverting nanoparticles
Opt Lett. 2009;34(17):2566-8 - PMID: 19724491 - PMCID: PMC2749971
Vinegoni C, Razansky D, Figueiredo JL, Nahrendorf M, Ntziachristos V, Weissleder R
Normalized Born ratio for fluorescence optical projection tomography.
Opt Lett. 2009;34(3):319-21 - PMID: 19183644 - PMCID: PMC2771918
McCarthy JR, Bhaumik J, Merbouh N, Weissleder R
High-yielding syntheses of hydrophilic conjugatable chlorins and bacteriochlorins.
Org Biomol Chem. 2009;7(17):3430-6 - PMID: 19675897 - PMCID: PMC2749955
Vonken EJ, Korosoglou G, Yu J, Schar M, Weissleder R, Stuber M
On the dual contrast enhancement mechanism in frequency-selective inversion-recovery magnetic resonance angiography (IRON-MRA).
Magn Reson Med. 2009;62(2):314-24 - PMID: 19526511 - PMCID: PMC2742771
Wildgruber M, Lee H, Chudnovskiy A, Yoon T, Etzrodt M, Pittet M, Nahrendorf M, Croce K, Libby P, Weissleder R, Swirski F
Monocyte subset dynamics in human atherosclerosis can be profiled with magnetic nano-sensors.
PLoS ONE. 2009;4(5):e5663 - PMID: 19461894 - PMCID: PMC2680949
Martinez-Boubeta C, Balcells L, Cristool R, Sanfeliu C, Rodriguez E, Weissleder R, Lope-Piedrafita S, Simeonidis K, Angelakeris M, Sandiumenge F, Calleja A, Casas L, Monty C, Martinez B
Self-assembled Multifunctional Fe/MgO Nanospheres for Magnetic Resonance Imaging and Hyperthermia.
NanoMedicine. 2009;:ePub - PMID: 19800988
Sheth RA, Upadhyay R, Stangenberg L, Sheth R, Weissleder R, Mahmood U
Improved detection of ovarian cancer metastases by intraoperative quantitative fluorescence protease imaging in a pre-clinical model.
Gynecol Oncol. 2009;112(3):616-22 - PMID: 19135233 - PMCID: PMC2664404
Yuan H, Pupo MT, Blois J, Smith A, Weissleder R, Clardy J, Josephson L
A stabilized demethoxyviridin derivative inhibits PI3 kinase.
Bioorg Med Chem Lett. 2009;19(15):4223-7 - PMID: 19523825
Sun N, Liu Y, Lee H, Weissleder R, Ham D
CMOS RF Biosensor Utilizing Nuclear Magnetic Resonance
IEEE J Solid-ST Circ. 2009;44:1629-1643
Rajendran R*, Ronald JA*, Ye T, Minqin R, Chen JW, Weissleder R, Rutt BK, Halliwell B, Watt F
Nuclear Microscopy: A Novel Technique for Quantitative Imaging of Gadolinium Distribution within Tissue Sections.
Microsc Micoranal. 2009;15:338-44 - PMID: 19575834
Bullain SS, Sahin A, Szentirmai O, Sanchez C, Lin N, Baratta E, Waterman P, Weissleder R, Mulligan RC, Carter BS
Genetically engineered T cells to target EGFRvIII expressing glioblastoma.
J Neuro-Oncol. 2009;94(3):373-82 - PMID: 19387557 - PMCID: PMC2730985
Ross RW, Zietman AL, Xie W, Coen JJ, Dahl DM, Shipley WU, Kaufman DS, Islam T, Guimaraes AR, Weissleder R, Harisinghani M
Lymphotropic nanoparticle-enhanced magnetic resonance imaging (LNMRI) identifies occult lymph node metastases in prostate cancer patients prior to salvage radiation therapy.
Clin Imag. 2009;33(4):301-5 - PMID: 19559353
Sosnovik DE, Nahrendorf M, Panizzi P, Matsui T, Aikawa E, Dai G, Li L, Reynolds F, Dorn GW, Weissleder R, Josephson L, Rosenzweig A
Molecular MRI Detects Low Levels of Cardiomyocyte Apoptosis in a Transgenic Model of Chronic Heart Failure.
Circ Cardiovasc Imaging. 2009;2(6):468-475 - PMID: 19920045
Kelly K*, Shaw SY*, Nahrendorf M, Kristoff K, Aikawa E, Schreiber SL, Clemons PA, Weissleder R.
Unbiased discovery of in vivo imaging probes through in vitro profiling of nanoparticle libraries.
Integrative Biology. 2009;1 :311-317
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Vinegoni C, Razansky D, Figueiredo JL, Fexon L, Pivovarov M, Nahrendorf M, Ntziachristos V, Weissleder R
Born Normalization for Fluorescence Optical Projection Tomography for Whole Heart Imaging
J Vis Exp. 2009;28:1389 - PMID: 19578329
Sosnovik DE, Garanger E, Aikawa E, Nahrendorf M, Figuiredo JL, Dai G, Reynolds F, Rosenzweig A, Weissleder R, Josephson L
Molecular MRI of Cardiomyocyte Apoptosis With Simultaneous Delayed-Enhancement MRI Distinguishes Apoptotic and Necrotic Myocytes In Vivo: Potential for Midmyocardial Salvage in Acute Ischemia.
Circ Cardiovasc Imaging. 2009;2(6):460-467 - PMID: 19920044
Nahrendorf M, Keliher E, Panizzi P, Zhang H, Hembrador S, Figueiredo JL, Aikawa E, Kelly K, Libby P, Weissleder R
18F-4V for PET-CT Imaging of VCAM-1 Expression in Atherosclerosis
Figueiredo JL, Nahrendorf M, Sosnovik DE, Weissleder R
MRI of a Novel Murine Working Heart Transplant Model
Circ Heart Failure. 2009;2:272-274 - PMID: 19718275 - PMCID: PMC2733535
Vinegoni C, Razansky D, Pitsouli C, Perrimon N, Ntziachristos V, Weissleder R
Mesoscopic fluorescence tomography for in-vivo imaging of developing Drosophila.
J Vis Exp. 2009;(30):pii:1510 - PMID: 19696720 - PMCID: PMC2736679
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Weissleder R, Pittet MJ
Imaging in the era of molecular oncology
Nature. 2008;452:580-589 - PMID: 18385732 - PMCID: PMC2708079
Lee H, Sun E, Ham D, Weissleder R
Chip-NMR biosensor for detection and molecular analysis of cells.
Nat Med. 2008;14(8):869-74 - PMID: 18607350 - PMCID: PMC2729055
Engelman JA, Chen L, Tan X, Crosby K, Guimaraes AR, Upadhyay R, Maira M, McNamara K, Perera SA, Song Y, Chirieac LR, Kaur R, Lightbown A, Simendinger J, Li T, Padera RF, Garcia-Echeverria C, Weissleder R, Mahmood U, Cantley LC, Wong KK
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.
Nat Med. 2008;14(12)::1351-1356 - PMID: 19029981 - PMCID: PMC2683415
Wurdinger T, Tannous BA, Saydam O, Skog J, Grau S, Soutschek J, Weissleder R, Breakefield XO, Krichevsky AM
miR-296 Regulates Growth Factor Receptor Overexpression in Angiogenic Endothelial Cells.
Cancer Cell. 2008;14(5):382-393 - PMID: 18977327 - PMCID: PMC2597164
Cortez-Retamozo V, Swirski FK, Waterman P, Yuan H, Figueiredo JL, Newton AP, Upadhyay R, Vinegoni C, Kohler R, Blois J, Smith A, Nahrendorf M, Josephson L, Weissleder R, Pittet MJ
Real-time assessment of inflammation and treatment response in a mouse model of allergic airway inflammation
J Clin Invest. 2008;:ePub - PMID: 18989378 - PMCID: PMC2579705
Wurdinger T, Badr C, Pike L, de Kleine R, Weissleder R, Breakefield XO, Tannous BA
A secreted luciferase for ex vivo monitoring of in vivo processes.
Nat Methods. 2008;5:171-173 - PMID: 18204457 - PMCID: PMC2699561
Kircher M, Grimm J, Swirski FK, Libby P, Gerszten R, Allport J, Weissleder R
Noninvasive in vivo imaging of monocyte trafficking to atherosclerotic lesions.
Circulation. 2008;117:388-395 - PMID: 18172031 - PMCID: PMC2705289
Nahrendorf M, Zhang H, Hembrador S, Panizzi P, Sosnovik D, Aikawa E, Libby P, Swirski F, Weissleder R.
Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis
Circulation. 2008;117:379-387 - PMID: 18158358 - PMCID: PMC2663426
Jaffer FA, Vinegoni C, John MC, Aikawa E, Gold HK, Finn AV, Ntziachristos V, Libby P, Weissleder R
Real-Time Catheter Molecular Sensing of Inflammation in Proteolytically Active Atherosclerosis.
Circulation. 2008;118(18):1802-9 - PMID: 18852366 - PMCID: PMC2729441
Nahrendorf M*, Sosnovik D*, Chen JW, Panizzi P, Figueiredo JL, Aikawa E, Libby P, Swirski FK, Weissleder R
Activatable Magnetic Resonance Imaging Agent Reports Myeloperoxidase Activity in Healing Infarcts and Noninvasively Detects the Antiinflammatory Effects of Atorvastatin on Ischemia-Reperfusion Injury.
Circulation. 2008;117(9):1153-60 - PMID: 18268141 - PMCID: PMC2673051
Kelly KA, Bardeesy N, Anbazhagan R, Gurumurthy S, Berger J, Alencar H, Depinho RA, Mahmood U, Weissleder R
Targeted Nanoparticles for Imaging Incipient Pancreatic Ductal Adenocarcinoma.
PLoS Med. 2008;5(4):e85 - PMID: 18416599 - PMCID: PMC2292750
Korosoglou G, Weiss RG, Kedziorek DA, Walczak P, Gilson WD, Schar M, Sosnovik DE, Kraitchman DL, Boston RC, Bulte JW, Weissleder R, Stuber M
Noninvasive detection of macrophage-rich atherosclerotic plaque in hyperlipidemic rabbits using positive contrast magnetic resonance imaging.
J Am Coll Cardiol. 2008;52:483-91 - PMID: 18672170 - PMCID: PMC2628468
Koh I, Hong R, Weissleder R, Josephson L
Sensitive NMR Sensors Detect Antibodies to Influenza.
Angew Chem Int Edit. 2008;47(22):4119-4121 - PMID: 18428168 - PMCID: PMC2668198
Niedre MJ, de Kleine RH, Aikawa E, Kirsch DG, Weissleder R, Ntziachristos V
Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo.
P Natl Acad Sci U S A. 2008;105(49)::19126-19131 - PMID: 19015534 - PMCID: PMC2614726
Breckwoldt M*, Chen JW*, Stangenberg L, Aikawa E, Rodriguez E, Qiu S, Moskowitz M, Weissleder R
Tracking the Inflammatory Response in Stroke in Vivo by Sensing the Enzyme Myeloperoxidase
P Natl Acad Sci U S A. 2008;105 (47):18584-18589 - PMID: 19011099 - PMCID: PMC2587593
Shaw SY, Westly EC, Pittet MJ, Subramanian A, Schreiber SL, Weissleder R
Perturbational profiling of nanomaterial biologic activity.
P Natl Acad Sci U S A. 2008;105:7387-7392 - PMID: 18492802 - PMCID: PMC2396702
Zhu H, Acquaviva J, Ramachandran P, Boskovitz A, Woolfenden S, Bronson R, Chen J, Weissleder R, Housman D, Charest A.
Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene function in gliomagenesis
PNAS. 2008;:ePub
Chen JW, Breckwoldt MO, Aikawa E, Chiang G, Weissleder R
Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis.
Brain. 2008;131(Pt 4):1123-33 - PMID: 18234693
McCarthy JR, Weissleder R
Multifunctional magnetic nanoparticles for targeted imaging and therapy.
Adv Drug Deliv Rev. 2008;60:1241-1251 - PMID: 18508157 - PMCID: PMC2583936
Kelly KA, Setlur SR, Ross R, Anbazhagan R, Waterman P, Rubin MA, Weissleder R
Detection of early prostate cancer using a hepsin-targeted imaging agent.
Cancer Res. 2008;68(7):2286-91 - PMID: 18381435 - PMCID: PMC2709884
Shah K, Hingtgen S, Kasmieh R, Figueiredo JL, Garcia-Garcia E, Martinez-Serrano A, Breakefield X, Weissleder R
Bimodal viral vectors and in vivo imaging reveal the fate of human neural stem cells in experimental glioma model.
J Neurosci. 2008;28:4406-13 - PMID: 18434519
Nahrendorf M, Aikawa E, Figueiredo JL, Stangenberg L, van den Borne S, Blankesteijn M, Sosnovik D, Jaffer F, Tung CH, Weissleder R
Transglutaminase activity in acute infarcts predicts healing outcome and let ventricular remodelling : implications for FXIII therapy and antithrombin use in myocardial infarction
Eur Heart J. 2008;29:445-454 - PMID: 18276618
Girnun GD, Chen L, Silvaggi J, Drapkin R, Chirieac LR, Padera RF, Upadhyay R, Vafai SB, Weissleder R, Mahmood U, Naseri E, Buckley S, Li D, Force J, McNamara K, Demetri G, Spiegelman BM, Wong KK
Regression of drug-resistant lung cancer by the combination of rosiglitazone and Carboplatin.
Clin Cancer Res. 2008;14(20):6478-86 - PMID: 18927287 - PMCID: PMC2696122
Perez JM, Grimm J, Josephson L, Weissleder R
Integrated nanosensors to determine levels and functional activity of human telomerase.
Neoplasia. 2008;10(10):1066-72 - PMID: 18813356 - PMCID: PMC2546593
Korosoglou G, Shah S, Vonken EJ, Gilson WD, Schar M, Tang L, Kraitchman DL, Boston RC, Sosnovik DE, Weiss RG, Weissleder R, Stuber M
Off-Resonance Angiography: A New Method to Depict Vessels--Phantom and Rabbit Studies.
Radiology. 2008;249(2)::501-509 - PMID: 18780823 - PMCID: PMC2657865
Gee MS, Upadhyay R, Bergquist H, Alencar H, Reynolds F, Maricevich M, Weissleder R, Josephson L, Mahmood U
Human Breast Cancer Tumor Models: Molecular Imaging of Drug Susceptibility and Dosing during HER2/neu-targeted Therapy.
Radiology. 2008;248(3):925-35 - PMID: 18647846
Garanger E, Aikawa E, Reynolds F, Weissleder R, Josephson L
Simplified syntheses of complex multifunctional nanomaterials.
Chem Commun. 2008;39:4792-4 - PMID: 18830495 - PMCID: PMC2692914
Blois J, Yuan H, Smith A, Pacold ME, Weissleder R, Cantley LC, Josephson L
Slow Self-Activation Enhances The Potency of Viridin Prodrugs.
J Med Chem. 2008;51(15):4699-707 - PMID: 18630894 - PMCID: PMC2663427
Hingtgen S, Ren X, Terwilliger E, Classon M, Weissleder R, Shah K
Targeting multiple pathways in gliomas with stem cell and viral delivered S-TRAIL and Temozolomide.
Mol Cancer Ther. 2008;7(11):3575-85 - PMID: 19001440 - PMCID: PMC2748233
Sosnovik DE, Nahrendorf M, Weissleder R
Targeted imaging of myocardial damage.
Nat Clin Pract Card. 2008;5 Suppl 2:S63-70 - PMID: 18641609 - PMCID: PMC2597275
Barnes KR, Blois J, Smith A, Yuan H, Reynolds F, Weissleder R, Cantley LC, Josephson L
Fate of a Bioactive Fluorescent Wortmannin Derivative in Cells.
Bioconjugate Chem. 2008;19:130-137 - PMID: 17988080
Shao F, Weissleder R, Hilderbrand SA
Monofunctional Carbocyanine Dyes for Bio- and Bioorthogonal Conjugation.
Bioconjugate Chem. 2008;19(12): :2487-2491 - PMID: 19053316 - PMCID: PMC2656649
Devaraj N, Weissleder R, Hilderbrand S
Tetrazine-Based Cycloadditions: Application to Pretargeted Live Cell Imaging.
Bioconjugate Chem. 2008;19(12):2297-2299 - PMID: 19053305 - PMCID: PMC2677645
Hilderbrand SA, Kelly KA, Niedre M, Weissleder R
Near Infrared Fluorescence-Based Bacteriophage Particles for Ratiometric pH Imaging.
Bioconjugate Chem. 2008;19(8):1635-9 - PMID: 18666791 - PMCID: PMC2705288
Sosnovik DE, Nahrendorf M, Weissleder R
Magnetic nanoparticles for MR imaging: agents, techniques and cardiovascular applications.
Basic Res Cardiol. 2008;103(2):122-30 - PMID: 18324368 - PMCID: PMC2597271
Nahrendorf M, Sosnovik DE, Weissleder R
MR-optical imaging of cardiovascular molecular targets.
Basic Res Cardiol. 2008;103:87-94 - PMID: 18324364 - PMCID: PMC2664635
Figueiredo JL, Passerotti CC, Sponholtz T, Nguyen HT, Weissleder R
A Novel Method of Imaging Calcium Urolithiasis Using Fluorescence.
J Urolology. 2008;179:1610-1614 - PMID: 18295253
Salthouse C, Hilderbrand S, Weissleder R, Mahmood U
Design and demonstration of a small-animal up-conversion imager.
Optics Express. 2008;16 (26):21731-7 - PMID: 19104605 - PMCID: PMC2717740
Taktak S, Weissleder R, Josephson L
Electrode Chemistry Yields a Nanoparticle-Based NMR Sensor for Calcium.
Langmuir. 2008;24 (14):7596-7598 - PMID: 18558729 - PMCID: PMC2748273
Hong R, Cima MJ, Weissleder R, Josephson L
Magnetic microparticle aggregation for viscosity determination by MR.
Magn Reson Med. 2008;59:515-520 - PMID: 18306403 - PMCID: PMC2740908
Jeong JH, Wang Z, Guimaraes AS, Ouyang X, Figueiredo JL, Ding Z, Jiang S, Guney I, Kang GH, Shin E, Hahn WC, Loda MF, Abate-Shen C, Weissleder R, Chin L
BRAF activation initiates but does not maintain invasive prostate adenocarcinoma.
PLoS ONE. 2008;3(12):e3949 - PMID: 19079609 - PMCID: PMC2597248
Gounaris E, Tung CH, Restaino C, Maehr R, Kohler R, Joyce JA, Plough HL, Barrett TA, Weissleder R, Khazaie K
Live imaging of cysteine-cathepsin activity reveals dynamics of focal inflammation, angiogenesis, and polyp growth.
PLoS ONE. 2008;3:e2916 - PMID: 18698347 - PMCID: PMC2488397
Guimaraes AR, Rakhlin E, Weissleder R, Thayer SP
Magnetic resonance imaging monitors physiological changes with antihedgehog therapy in pancreatic adenocarcinoma xenograft model.
Pancreas. 2008;37(4):440-4 - PMID: 18953259
Korosoglou G, Tang L, Kedziorek D, Cosby K, Gilson WD, Vonken EJ, Schar M, Sosnovik D, Kraitchman DL, Weiss RG, Weissleder R, Stuber M
Positive contrast MR-lymphography using inversion recovery with ON-resonant water suppression (IRON).
J Magn Reson Imaging. 2008;27(5):1175-1180 - PMID: 18425827 - PMCID: PMC2740932
Guimaraes AR, Tabatabei S, Dahl D, McDougal WS, Weissleder R, Harisinghani MG
Pilot Study Evaluating Use of Lymphotrophic Nanoparticle-Enhanced Magnetic Resonance Imaging for Assessing Lymph Nodes in Renal Cell Cancer.
Urology. 2008;71(4):708-12 - PMID: 18295316
Korngold EC, Jaffer FA, Weissleder R, Sosnovik DE
Noninvasive imaging of apoptosis in cardiovascular disease.
Heart Fail Rev. 2008;13(2)::163-173 - PMID: 18074226 - PMCID: PMC2597223
Rusanescu G, Weissleder R, Aikawa E
Notch Signaling in Cardiovascular Disease and Calcification
Curr Cardiol Review. 2008;4(3):148-156
Lin KY, Maricevich M, Bardeesy N, Weissleder R, Mahmood U
In vivo quantitative microvasculature phenotype imaging of healthy and malignant tissues using a fiber-optic confocal laser microprobe.
Transl Oncol. 2008;1:84-94 - PMID: 18633456 - PMCID: PMC2510813
Salthouse CD, Weissleder R, Mahmood U
Development of a Time Domain Fluorimeter for Fluorescent Lifetime Multiplexing Analysis.
IEEE Trans Biomed Circuits Syst. 2008;2(3):204-211 - PMID: 19830273 - PMCID: PMC2760943
49
Ventura A, Kirsch DG, McLaughlin ME, Tuveson DA, Grimm J, Lintault L, Newman J, Reczek EE, Weissleder R, Jacks T
Restoration of p53 function leads to tumour regression in vivo.
Nature. 2007;445:661-5 - PMID: 17251932
Kirsch DG, Dinulescu DM, Miller JB, Grimm J, Santiago PM, Young NP, Nielsen GP, Quade BJ, Chaber CJ, Schultz CP, Takeuchi O, Bronson RT, Crowley D, Korsmeyer SJ, Yoon SS, Hornicek FJ, Weissleder R, Jacks T
A spatially and temporally restricted mouse model of soft tissue sarcoma.
Nat Med. 2007;13(8):992-997 - PMID: 17676052
Swirski FK, Libby P, Aikawa E, Alcaide P, Luscinskas FW, Weissleder R, Pittet MJ
Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata
J Clin Invest. 2007;117(1):195-205 - PMID: 17200719 - PMCID: PMC1716211
Kurozumi K, Hardcastle J, Thakur R, Yang M, Christoforidis G, Fulci G, Hochberg F, Weissleder R, Carson W, Chiocca A, Kaur B.
Effect of Tumor Microenvironment Modulation on the Efficacy of Oncolytic Virus Therapy
J Natl Cancer I. 2007;(99) 23:1768-1781 - PMID: 18042934
Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo JL, Libby P, Weissleder R, Pittet MJ
The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions.
J Exp Med. 2007;204(12):3037-47 - PMID: 18025128 - PMCID: PMC2118517
Wu HJ, Sawaya H, Binstadt B, Brickelmaier M, Blasius A, Gorelik L, Mahmood U, Weissleder R, Carulli J, Benoist C, Mathis D.
Inflammatory arthritis can be reined in by CpG-induced DC-NK cell cross talk
J Exp Med. 2007;204:1911-1922 - PMID: 17646407 - PMCID: PMC2118664
Aikawa E, Nahrendorf M, Figueiredo JL, Swirski F, Shtatland T, Kohler RH, Jaffer F, Aikawa M, Weissleder R.
Osteogenesis associates with inflammation in early-stage atherosclerosis evaluated by molecular imaging in vivo.
Circulation. 2007;116(24):2841-50 - PMID: 18040026
Aikawa E, Nahrendorf M, Sosnovik D, Lok VM, Jaffer FA, Aikawa M, Weissleder R
Multimodality Molecular Imaging Identifies Proteolytic and Osteogenic Activities in Early Aortic Valve Disease.
Circulation. 2007;115:377-386 - PMID: 17224478
Jaffer FA, Kim DE, Quinti L, Tung CH, Aikawa E, Pande AN, Kohler RH, Shi GP, Libby P, Weissleder R
Optical Visualization of Cathepsin K Activity in Atherosclerosis With a Novel, Protease-Activatable Fluorescence Sensor.
Circulation. 2007;115(17):2292-8 - PMID: 17420353
Sosnovik DE, Nahrendorf M, Weissleder R
Molecular magnetic resonance imaging in cardiovascular medicine.
Circulation. 2007;115(15):2076-86 - PMID: 17438163
Sosnovik DE, Nahrendorf M, Deliolanis N, Novikov M, Aikawa E, Josephson L, Rosenzweig A, Weissleder R, Ntziachristos V
Fluorescence Tomography and Magnetic Resonance Imaging of Myocardial Macrophage Infiltration in Infarcted Myocardium In Vivo.
Circulation. 2007;115:1384-1391 - PMID: 17339546
Jaffer FA, Libby P, Weissleder R
Molecular imaging of cardiovascular disease.
Circulation. 2007;116(9):1052-61 - PMID: 17724271
Nahrendorf M, Sosnovik D, Waterman P, Swirski F, Pande A, Aikawa E, Figueiredo JL, Pittet M, Weissleder R.
Dual channel optical tomographic imaging of leukocyte recruitment and protease activity in the healing myocardial infarct
Circ Res. 2007;100:1218-1225 - PMID: 17379832
Gounaris E, Erdman SE, Restaino C, Gurish MF, Friend DS, Gounari F, Lee DM, Zhang G, Glickman JN, Shin K, Rao VP, Poutahidis T, Weissleder R, McNagny KM, Khazaie K
Mast cells are an essential hematopoietic component for polyp development.
P Natl Acad Sci U S A. 2007;104:19977-82 - PMID: 18077429 - PMCID: PMC2148408
Pittet M, Grimm J, Berger C, Tamura T, Wojtkiewicz G, Nahrendorf M, Romero P, Swirski F, Weissleder R.
In vivo imaging of T cell delivery to tumors after adoptive transfer therapy
P Natl Acad Sci U S A. 2007;104:12457-12461 - PMID: 17640914 - PMCID: PMC1941490
Fulci G, Dmitrieva N, Gianni D, Fontana EJ, Pan X, Lu Y, Kaufman CS, Kaur B, Lawler SE, Lee RJ, Marsh CB, Brat DJ, van Rooijen N, Rachamimov AS, Hochberg FH, Weissleder R, Martuza RL, Chiocca EA
Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses.
Cancer Res. 2007;67(19):9398-406 - PMID: 17909049
Corsten MF, Miranda R, Kasmieh R, Krichevsky AM, Weissleder R, Shah K
MicroRNA-21 Knockdown Disrupts Glioma Growth In vivo and Displays Synergistic Cytotoxicity with Neural Precursor Cell Delivered S-TRAIL in Human Gliomas.
Cancer Res. 2007;67(19):8994-9000 - PMID: 17908999
Arwert E, Hingtgen S, Figueiredo JL, Bergquist H, Mahmood U, Weissleder R, Shah K.
Visualizing the dynamics of EGFR activity and antiglioma therapies in vivo
Cancer Res. 2007;67 (15):7335-7342 - PMID: 17671203
Izmailova ES, Paz N, Alencar H, Chun M, Schopf L, Hepperle M, Lane JH, Harriman G, Xu Y, Ocain T, Weissleder R, Mahmood U, Healy AM, Jaffee B
Use of molecular imaging to quantify response to IKK-2 inhibitor treatment in murine arthritis.
Arth Rheum/AR C Res. 2007;56(1):117-128 - PMID: 17195214
Sosnovik DE, Weissleder R
Emerging concepts in molecular MRI.
Curr Opin Biotech. 2007;18(1):4-10 - PMID: 17126545
Kozloff KM, Weissleder R, Mahmood U
Non-Invasive Optical Detection of Bone Mineral.
J Bone Miner Res. 2007;(22) 8:1208-1216 - PMID: 17488196
Shepherd J, Hilderbrand SA, Waterman P, Heinecke JW, Weissleder R, Libby P
A fluorescent probe for the detection of myeloperoxidase activity in atherosclerosis-associated macrophages.
Chem Biol. 2007;14:1221-31 - PMID: 18022561
Yuan H, Barnes KR, Weissleder R, Cantley L, Josephson L
Covalent Reactions of Wortmannin under Physiological Conditions.
Chem Biol. 2007;14(3):321-8 - PMID: 17379147
Kock N, Kasmieh R, Weissleder R, Shah K
Tumor Therapy Mediated by Lentiviral Expression of shBcl-2 and S-TRAIL.
Neoplasia. 2007;9(5):435-42 - PMID: 17534449 - PMCID: PMC1877976
Harisinghani M, Ross R, Guimaraes A, Weissleder R
Utility of a New Bolus-Injectable Nanoparticle for Clinical Cancer Staging
Neoplasia. 2007;(9)12:1160-1165 - PMID: 18084623 - PMCID: PMC2134912
Upadhyay R, Sheth RA, Weissleder R, Mahmood U
Quantitative Real-time Catheter-based Fluorescence Molecular Imaging in Mice.
Radiology. 2007;245(2):523-31 - PMID: 17940307
Alencar H, Funovics MA, Figueiredo J, Sawaya H, Weissleder R, Mahmood U
Colonic Adenocarcinomas: Near-Infrared Microcatheter Imaging of Smart Probes for Early Detection.
Radiology. 2007;244(1):232-8 - PMID: 17507718
Montet X, Figueiredo JL, Alencar H, Ntziachristos V, Mahmood U, Weissleder R.
Tomographic fluorescence imaging of tumor vascular volume in mice.
Radiology. 2007;242 (3):751-758 - PMID: 17325064
Taktak S, Sosnovik D, Cima MJ, Weissleder R, Josephson L
Multiparameter Magnetic Relaxation Switch Assays.
Anal Chem. 2007;(79) 23:8863-9 - PMID: 17983206
Hilderbrand S, Weissleder R.
Optimized pH-responsive cyanine fluorochromes for detection of acidic environments
Chem Commun. 2007;(26):2747-9 - PMID: 17594041
Kim YM, Hilderbrand S, Weissleder R, Tung CH
Sugar sensing based on induced pH changes
Chem Commun. 2007;(22):2299-2301 - PMID: 17534523
Bouffard J, Kim Y, Swager TM, Weissleder R, Hilderbrand SA
A Highly Selective Fluorescent Probe for Thiol Bioimaging.
Org Lett. 2007;10 :37-40 - PMID: 18062694
Gee MS, Upadhyay R, Bergquist H, Weissleder R, Josephson L, Mahmood U
Multiparameter noninvasive assessment of treatment susceptibility, drug target inhibition and tumor response guides cancer treatment.
Int J Cancer. 2007;(121) 11:2492-2500 - PMID: 17683072
Law B, Weissleder R, Tung CH
Protease-Sensitive Fluorescent Nanofibers.
Bioconjugate Chem. 2007;(18) 6 ::1701-1704 - PMID: 17915958 - PMCID: PMC2528070
Nahrendorf M, Badea C, Hedlund LW, Figueiredo JL, Sosnovik DE, Johnson GA, Weissleder R
High Resolution Imaging of Murine Myocardial Infarction With Delayed Enhancement Cine Micro-CT.
Am J Physiol-Heart C. 2007;292(6):3172-8 - PMID: 17322414 - PMCID: PMC2680216
Shtatland T, Guettler D, Kossodo M, Pivovarov M, Weissleder R
PepBank - a database of peptides based on sequence text mining and public peptide data sources.
BMC Bioinformatics. 2007;8(1):280 - PMID: 17678535 - PMCID: PMC1976427
Ho NH, Weissleder R, Tung CH
A Self-Immolative Reporter For beta-Galactosidase Sensing.
Chembiochem. 2007;8:560-566 - PMID: 17300128
Tam JM, Upadhyay R, Pittet MJ, Weissleder R, Mahmood U
Improved in vivo whole-animal detection limits of green fluorescent protein-expressing tumor lines by spectral fluorescence imaging.
Mol Imaging. 2007;6(4):269-76 - PMID: 17711782
Montet-Abou K, Montet X, Weissleder R, Josephson L
Cell internalization of magnetic nanoparticles using transfection agents.
Mol Imaging. 2007;(6) 1:1-9 - PMID: 17311760
Sheth RA, Upadhyay R, Weissleder R, Mahmood U
Real-time multichannel imaging framework for endoscopy, catheters, and fixed geometry intraoperative systems.
Mol Imaging. 2007;6(3):147-55 - PMID: 17532881
Farrar CT, Dai G, Novikov M, Rosenzweig A, Weissleder R, Rosen BR, Sosnovik DE
Impact of field strength and iron oxide nanoparticle concentration on the linearity and diagnostic accuracy of off-resonance imaging.
NMR Biomed. 2007;:ePub - PMID: 17918777 - PMCID: PMC2629945
Kelly KA, Carson J, McCarthy JR, Weissleder R
Novel Peptide Sequence ("IQ-tag") with High Affinity for NIR Fluorochromes Allows Protein and Cell Specific Labeling for In Vivo Imaging.
PLoS ONE. 2007;2:e665 - PMID: 17653285 - PMCID: PMC1919420
Swirski FK, Berger CR, Figueiredo JL, Mempel TR, von Andrian UH, Pittet MJ, Weissleder R
A near-infrared cell tracker reagent for multiscopic in vivo imaging and quantification of leukocyte immune responses.
PLoS ONE. 2007;2(10):e1075 - PMID: 17957257 - PMCID: PMC2034600
McCarthy JR, Weissleder R
Model Systems for Fluorescence and Singlet Oxygen Quenching by Metalloporphyrins.
ChemMedChem. 2007;2:360-365 - PMID: 17245681
McCarthy J, Kelly KA, Sun EY, Weissleder R.
Targeted delivery of multifunctional magnetic nanoparticles
NanoMedicine. 2007;2(2):153-167 - PMID: 17716118
Kim Y, Choi Y, Weissleder R, Tung CH
Membrane permeable esterase-activated fluorescent imaging probe.
Bioorg Med Chem Lett. 2007;17(18):5054-7 - PMID: 17664067 - PMCID: PMC1995663
Nahrendorf M, Weissleder R
Advances in cardiovascular medicine through molecular imaging.
Radiologe. 2007;47(1):18-24 - PMID: 17187263
Grimm J, Kircher MF, Weissleder R
Cell tracking : Principles and applications.
Radiologe. 2007;47(1):25-33 - PMID: 17187264
Hilderbrand SA, Weissleder R
One-Pot Synthesis of New Symmetric and Asymmetric Xanthene Dyes.
Tetrahedron Lett. 2007;48(25):4383-4385 - PMID: 19834587 - PMCID: PMC2761723
49
Binstadt BA, Patel PR, Alencar H, Nigrovic PA, Lee DM, Mahmood U, Weissleder R, Mathis D, Benoist C
Particularities of the vasculature can promote the organ specificity of autoimmune attack.
Nat Immunol. 2006;7(3):284-92 - PMID: 16444258
Ji H, Li D, Chen L, Shimamura T, Kobayashi S, McNamara K, Mahmood U, Mitchell A, Sun Y, Al-Hashem R, Chirieac LR, Padera R, Bronson RT, Kim W, Janne PA, Shapiro GI, Tenen D, Johnson BE, Weissleder R, Sharpless NE, Wong KK
The impact of human EGFR kinase domain mutations on lung tumorigenesis and in vivo sensitivity to EGFR-targeted therapies.
Cancer Cell. 2006;9(6):485-95 - PMID: 16730237
Rabin O, Manuel Perez J, Grimm J, Wojtkiewicz G, Weissleder R
An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles.
Nat Mater. 2006;5(2):118-22 - PMID: 16444262
Mempel T, Pittet M, Khazaie K, Weninger W, Weissleder R, von Boehmer H, von Adrian U.
Regulatory T cells reversibly suppress cytotoxic T cell function independent of effector differentiation
Immunity. 2006;25(1):129-41 - PMID: 16860762
Zhang M, Alicot EM, Chiu I, Li J, Verna N, Vorup-Jensen T, Kessler B, Shimaoka M, Chan R, Friend D, Mahmood U, Weissleder R, Moore FD, Carroll MC
Identification of the target self-antigens in reperfusion injury.
J Exp Med. 2006;203(1):141-152 - PMID: 16390934 - PMCID: PMC2118091
Tannous B*, Grimm J*, Perry K, Chen J, Weissleder R, Breakefield X.
Metabolic Biotinylation of Cell Surface Receptors for in vivo Imaging
Nat Methods. 2006;3(5):391-396 - PMID: 16628210
Deguchi JO, Aikawa M, Tung CH, Aikawa E, Kim DE, Ntziachristos V, Weissleder R, Libby P
Inflammation in Atherosclerosis. Visualizing Matrix Metalloproteinase Action in Macrophages In Vivo.
Circulation. 2006;114:55-62 - PMID: 16801460
Nahrendorf M, Jaffer FA, Kelly KA, Sosnovik DE, Aikawa E, Libby P, Weissleder R
Noninvasive Vascular Cell Adhesion Molecule-1 Imaging Identifies Inflammatory Activation of Cells in Atherosclerosis.
Circulation. 2006;114:1504-1511 - PMID: 17000904
Nahrendorf M, Hu K, Frantz S, Jaffer F, Tung CH, Hiller KH, Voll S, Nordbeck P, Sosnovik D, Gattenlohner S, Novikov M, Dickneite G, Reed G, Jakob P, Rosenzweig A, Bauer W, Weissleder R, Ertl G.
Factor XIII Deficiency Causes Cardiac Rupture, Impairs Wound Healing, and Aggravates Cardiac Remodeling in Mice with Myocardial Infarction
Circulation. 2006;113(9):1196-1202 - PMID: 16505171
Jaffer F, Libby P, Weissleder R.
Molecular and Cellular Imaging of Atherosclerosis, Emerging Applications
J Am Coll Cardiol. 2006;47:1328-1338 - PMID: 16580517
Quinti L, Weissleder R, Tung CH
A Fluorescent Nanosensor for Apoptotic Cells
Nano Lett. 2006;6 (3):488-490 - PMID: 16522048
Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA
Both p16Ink4a and the p19Arf-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse.
P Natl Acad Sci U S A. 2006;103:5947-5952 - PMID: 16585505 - PMCID: PMC1458678
Fulci G, Breymann L,Gianni D, Kurozomi K, Rhee S, Yu J, Kaur B, Louis D, Weissleder R, Caligiuri M, Chiocca A.
Cyclophosphamide enhances glioma virotherapy by inhibiting innate immune responses
P Natl Acad Sci U S A. 2006;103:12873-12878 - PMID: 16908838 - PMCID: PMC1568940
Swirski FK, Pittet MJ, Kircher MF, Aikawa E, Jaffer FA, Libby P, Weissleder R
Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of disease.
P Natl Acad Sci U S A. 2006;103(27):10340-5 - PMID: 16801531 - PMCID: PMC1502459
Choi YD, Weissleder R, Tung CH.
Selective antitumor effect of novel protease-mediated photodynamic agent
Cancer Res. 2006;66 (14):7225-7229 - PMID: 16849570
Deramaudt TB, Takaoka M, Upadhyay R, Bowser MJ, Porter J, Lee A, Rhoades B, Johnstone CN, Weissleder R, Hingorani SR, Mahmood U, Rustgi AK
N-Cadherin and Keratinocyte Growth Factor Receptor Mediate the Functional Interplay between Ki-RASG12V and p53V143A in Promoting Pancreatic Cell Migration, Invasion, and Tissue Architecture Disruption.
Mol Cell Biol. 2006;26(11):4185-200 - PMID: 16705170 - PMCID: PMC1489079
McCarthy J, Jaffer F, Weissleder R.
A Macrophage Targeted Theranostic Nanoparticle for Biomedical Applications
Small. 2006;2(8-9):983-987 - PMID: 17193154
Sun EY, Weissleder R, Josephson L.
Continuous Analyte Sensing with Magnetic Nanoswitches
Small. 2006;(2) 10:1144-1147 - PMID: 17193579
Vianello F, Papeta N, Chen T, Kraft P, White N, Hart WK, Kircher MF, Swart E, Rhee S, Palu G, Irimia D, Toner M, Weissleder R, Poznansky MC
Murine B16 Melanomas Expressing High Levels of the Chemokine Stromal-Derived Factor-1/CXCL12 Induce Tumor-Specific T Cell Chemorepulsion and Escape from Immune Control.
J Immunol. 2006;176(5):2902-14 - PMID: 16493048
Campanella GS, Grimm J, Manice LA, Colvin RA, Medoff BD, Wojtkiewicz GR, Weissleder R, Luster AD
Oligomerization of CXCL10 Is Necessary for Endothelial Cell Presentation and In Vivo Activity.
J Immunol. 2006;177:6991-8 - PMID: 17082614
Funovics MA, Alencar H, Montet X, Weissleder R, Mahmood U
Simultaneous fluorescence imaging of protease expression and vascularity during murine colonoscopy for colonic lesion characterization.
Gastrointest Endosc. 2006;64(4):589-97 - PMID: 16996355
Lamfers ML, Fulci G, Gianni D, Tang Y, Kurozumi K, Kaur B, Moeniralm S, Saeki Y, Carette JE, Weissleder R, Vandertop WP, van Beusechem VW, Dirven CM, Chiocca EA
Cyclophosphamide Increases Transgene Expression Mediated by an Oncolytic Adenovirus in Glioma-Bearing Mice Monitored by Bioluminescence Imaging.
Mol Ther. 2006;4(6):779-88 - PMID: 16996314
Yen L, Magnier M, Weissleder R, Stockwell BR, Mulligan RC
Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries.
RNA. 2006;12(5):797-806 - PMID: 16556935 - PMCID: PMC1440893
Montet X, Montet-Abou K, Reynolds F, Weissleder R, Josephson L.
Nanoparticle Imaging of Integrins on Tumor Cells
Neoplasia. 2006;8(3):214-222 - PMID: 16611415 - PMCID: PMC1578521
Trehin R, Figueiredo JL, Pittet M, Weissleder R, Josephson L, Mahmood U.
Fluorescent Nanoparticle Uptake for Brain Tumor Visualization
Neoplasia. 2006;8(4):302-311 - PMID: 16756722 - PMCID: PMC1600680
Newton JR, Kelly KA, Mahmood U, Weissleder R, Deutscher SL
In vivo selection of phage for the optical imaging of PC-3 human prostate carcinoma in mice.
Neoplasia. 2006;8(9):772-80 - PMID: 16984734 - PMCID: PMC1584300
Kelly KA, Waterman P, Weissleder R.
In vivo imaging of molecularly targeted phage
Neoplasia. 2006;8 (12):1011-1018
Kim DE, Tsuji K, Kim YR, Mueller FJ, Eom HS, Snyder EY, Lo EH, Weissleder R, Schellingerhout D
Neural Stem Cell Transplant Survival in Brains of Mice: Assessing the Effect of Immunity and Ischemia by using Real-time Bioluminescent Imaging.
Radiology. 2006;241(3):822-830 - PMID: 17114629
Chen JW, Querol Sans M, Bogdanov Jr A, Weissleder R
Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates
Radiology. 2006;240 (2):473-81 - PMID: 16864673
Jaffer FA, Sosnovik DE, Nahrendorf M, Weissleder R
Molecular imaging of myocardial infarction.
J Mol Cell Cardiol. 2006;41:921-933 - PMID: 17067633
Galande A, Hilderbrand S, Weissleder R, Tung CH.
Enzyme-targeted fluorescent imaging probes on a multiple antigenic peptide core
J Med Chem. 2006;49(15):4715-20 - PMID: 16854078
Yuan H, Luo J, Weissleder R, Cantley L, Josephson L
Wortmannin-C20 Conjugates Generate Wortmannin.
J Med Chem. 2006;49(2):740-747 - PMID: 16420059
Montet X, Funovics M, Montet-Abou K, Weissleder R, Josephson L.
Multivalent effects of RGD peptides obtained by nanoparticle display
J Med Chem. 2006;49(20):6087-6093
Law B, Quinti L, Choi YD, Weissleder R, Tung CH
A Mitochondrial Targeted Fusion Peptide Exhibits Remarkable Cytotoxicity
Mol Cancer Ther. 2006;5 (8):1944-1949 - PMID: 16928814
Kang HW, Torres D, Wald L, Weissleder R, Bogdanov AA
Targeted imaging of human endothelial-specific marker in a model of adoptive cell transfer.
Lab Invest. 2006;86(6):599-609 - PMID: 16607378
Montet X, Yuan H, Weissleder R, Josephson L
Enzyme-based visualization of receptor-ligand binding in tissues.
Lab Invest. 2006;86(5):517-25 - PMID: 16568109
Sun EY, Josephson L, Kelly KA, Weissleder R
Development of nanoparticle libraries for biosensing.
Bioconjugate Chem. 2006;17(1):109-13 - PMID: 16417258
Banerjee P, Weissleder R, Bogdanov A
Linear Polyethyleneimine Grafted to a Hyperbranched Poly(ethylene glycol)-like Core: A Copolymer for Gene Delivery.
Bioconjugate Chem. 2006;17(1):125-31 - PMID: 16417260
Montet X, Weissleder R, Josephson L.
Imaging pancreatic cancer with a peptide-nanoparticle conjugate targeted to normal pancreas
Bioconjugate Chem. 2006;17(4):905-911 - PMID: 16848396
Galande A, Weissleder R, Tung CH.
Fluorescence Probe with a pH-Sensitive Trigger
Bioconjugate Chem. 2006;17 (2):255-257 - PMID: 16536452
Messerli SM, Prabhakar S, Tang Y, Mahmood U, Weissleder R, Bronson R, Martuza R, Rabkin S, Breakefield XO
Treatment of schwannomas with an oncolytic recombinant herpes simplex virus in murine models of neurofibromatosis type 2.
Hum Gene Ther. 2006;17(1):20-30 - PMID: 16409122
Law B, Weissleder R, Tung CH
Peptide-based Biomaterials for Protease-Enhanced Drug Delivery
Biomacromolecules. 2006;7(4):1261-1265 - PMID: 16602747
Kelly KA, Allport JR, Yu AM, Sinh S, Sage EH, Gerszten RE, Weissleder R
SPARC is a VCAM-1 counter-ligand that mediates leukocyte transmigration.
J Leukocyte biol. 2006;:ePub - PMID: 17178915
Jaffer F, Nahrendorf M, Sosnovik D, Kelly KA, Aikawa E, Weissleder R
Cellular Imaging of Inflammation in Atherosclerosis Using Magnetofluorescent Nanomaterials
Mol Imaging. 2006;(5) 2 :85-92 - PMID: 16954022
Zacharakis G, Shih H, Ripoll J, Weissleder R, Ntziachristos V
Normalized transillumination of fluorescent proteins in small animals.
Mol Imaging. 2006;5 (2):153-9 - PMID: 16954030
Sun EY, Josephson L, Weissleder R.
Clickable nanoparticles for targeted imaging
Mol Imaging. 2006;(5) 2:122-128 - PMID: 16954026
Kelly KA, Clemons PA, Yu AM, Weissleder R
High throughput identification of phage-derived imaging agents
Mol Imaging. 2006;5(1):24-30 - PMID: 16779967
Hsiao JK, Law B, Weissleder R, Tung CH
In-vivo imaging of tumor associated urokinase-type plasminogen activator activity.
J Biomed Opt. 2006;11(3):34013 - PMID: 16822063
Pande AN, Kohler RH, Aikawa E, Weissleder R, Jaffer FA
Detection of macrophage activity in atherosclerosis in vivo using multichannel, high-resolution laser scanning fluorescence microscopy.
J Biomed Opt. 2006;11(2):21009 - PMID: 16674184
Kelly KA, Nahrendorf M, Yu AM, Reynolds F, Weissleder R
In Vivo Phage Display Selection Yields Atherosclerotic Plaque Targeted Peptides for Imaging.
Mol Imaging Biol. 2006;8(4):201-7 - PMID: 16791746
Nahrendorf M, Weissleder R, Ertl G
Does FXIII Deficiency Impair Wound Healing after Myocardial Infarction?
PLoS ONE. 2006;1:e48 - PMID: 17183677 - PMCID: PMC1762326
Ho NH, Weissleder R, Tung CH
Development of water-soluble far-red fluorogenic dyes for enzyme sensing
Tetrahedron. 2006;62:578-585
Choi YD, McCarthy J, Weissleder R, Tung CH
Conjugation of a Photosensitizer to an Oligoarginine-based Cell-penetrating Peptide Increases the Efficacy of Photodynamic Therapy
ChemMedChem. 2006;1(4):458-463 - PMID: 16892381
Choi Y, Weissleder R, Tung CH
Protease-mediated phototoxicity of a polylysine-chlorin(E6) conjugate.
ChemMedChem. 2006;1:698-701 - PMID: 16902920
Montet X, Rajopadhye M, Weissleder R.
An albumin-activated far-red fluorochrome for in vivo imaging
ChemMedChem. 2006;1(1):66-69 - PMID: 16892337
Ho NH, Weissleder R, Tung CH
Development of a dual fluorogenic and chromogenic dipeptidyl peptidase IV substrate.
Bioorg Med Chem. 2006;16:2599-2602 - PMID: 16517162
Harisinghani MG, Saksena MA, Hahn PF, King B, Kim J, Torabi MT, Weissleder R
Ferumoxtran-10-Enhanced MR Lymphangiography: Does Contrast-Enhanced Imaging Alone Suffice for Accurate Lymph Node Characterization?
Am J Roentgenol. 2006;186(1):144-8 - PMID: 16357394
Saksena M, Harisinghani M, Hahn P, Kim J, Saokar A, King B, Weissleder R
Comparison of lymphotropic nanoparticle-enhanced MRI sequences in patients with various primary cancers.
Am J Roentgenol. 2006;187(6):W582-8 - PMID: 17114509
Hynynen K, McDannold N, Vykhodtseva N, Raymond S, Weissleder R, Jolesz FA, Sheikov N
Focal disruption of the blood-brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery.
J Neurosurg. 2006;105:445-54 - PMID: 16961141
Pittet M, Swirski F, Reynolds F, Josephson L, Weissleder R.
Labeling of immune cells for in vivo imaging using magnetofluorescent nanoparticles
Nat Protoc. 2006;1(1):73-79
Weissleder R, Imhof H
Molecular imaging -a new emphasis in radiology
Radiologe. 2006;:epub - PMID: 17136404
62
Jaffer F, Weissleder R
Molecular Imaging in the Clinical Arena
JAMA-J Am Med Assoc. 2005;293(7):855-62 - PMID: 15713776
Ntziachristos V, Ripoll J, Wang L, Weissleder R
Looking and Listening to light: the evolution of whole-body photonic imaging
Nat Biotechnol. 2005;23:313-320 - PMID: 15765087
Weissleder R, Kelly K, Sun E, Shtatland T, Josephson L.
Cell-specific targeting of nanoparticles by multivalent attachment of small molecules
Nat Biotechnol. 2005;23:1418-1423 - PMID: 16244656
Turvey SE, Swart E, Denis MC, Mahmood U, Benoist C, Weissleder R, Mathis D.
Noninvasive imaging of pancreatic inflammation and its reversal in type 1 diabetes
J Clin Invest. 2005;115(9):2454-2461 - PMID: 16110329 - PMCID: PMC1187933
Chen J, Tung CH, Allport JR, Chen S, Weissleder R, Huang PL.
Near-Infrared Fluorescent Imaging of Matrix Metalloproteinase Activity After Myocardial Infarction
Circulation. 2005;111:1800-1805 - PMID: 15809374
Kelly KA, Allport JR, Tsourkas A, Shinde-Patil VR, Josephson L, Weissleder R.
Detection of Vascular Adhesion Molecule-1 Expression Using a Novel Multimodal Nanoparticle
Circ Res. 2005;96(3):327-36 - PMID: 15653572
McCarthy JR, Perez JM, Brueckner C, Weissleder R
Polymeric Nanoparticle Preparation that Eradicates Tumors.
Nano Lett. 2005;5:2552-6 - PMID: 16351214
Zacharakis G, Kambara H, Shih H, Ripoll J, Grimm J, Saeki Y, Weissleder R, Ntziachristos V.
Volumetric tomography of fluorescent proteins through small animals in vivo
P Natl Acad Sci U S A. 2005;102:18252-18257 - PMID: 16344470 - PMCID: PMC1317905
Chen ML, Pittet MJ, Gorelik L, Flavell RA, Weissleder R, von Boehmer H, Khazaie K.
Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-{beta} signals in vivo
Grimm J, Kirsch DG, Windsor SD, Kim CF, Santiago PM, Ntziachristos V, Jacks T, Weissleder R.
Use of gene expression profiling to direct in vivo molecular imaging of lung cancer
P Natl Acad Sci U S A. 2005;102(40):14404-14409 - PMID: 16183744 - PMCID: PMC1242291
Shah K, Bureau E, Kim DE, Yang K, Tang Y, Weissleder R, Breakefield XO.
Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression
Ann Neurol. 2005;57(1):34-41 - PMID: 15622535
Montet X, Ntziachristos V, Grimm J, Weissleder R.
Tomographic Fluorescence Mapping of Tumor Targets
Cancer Res. 2005;65 (14):6330-6336 - PMID: 16024635
Kim YR, Yudina A, Figueiredo J, Reichardt W, Hu-Lowe D, Petrovsky A, Kang HW, Torres D, Mahmood U, Weissleder R, Bogdanov AA Jr.
Detection of Early Antiangiogenic Effects in Human Colon Adenocarcinoma Xenografts: In vivo Changes of Tumor Blood Volume in Response to Experimental VEGFR Tyrosine Kinase Inhibitor
Cancer Res. 2005;65(20):9253-60 - PMID: 16230386
Tang Y, Kim M, Carrasco D, Kung AL, Chin L, Weissleder R.
In vivo assessment of RAS-dependent maintenance of tumor angiogenesis by real-time magnetic resonance imaging
Cancer Res. 2005;65(18):8324-30 - PMID: 16166309
Kelloff GJ, Krohn KA, Larson SM, Weissleder R, Mankoff DA, Hoffman JM, Link JM, Guyton KZ, Eckelman WC, Scher HI, O
The progress and promise of molecular imaging probes in oncologic drug development.
Clin Cancer Res. 2005;11(22):7967-85 - PMID: 16299226
Shah K, Tung CH, Breakefield X, Weissleder R.
In vivo imaging of S-TRAIL-mediated tumor regression and apoptosis
Mol Ther. 2005;11 (6):926-931 - PMID: 15922963
Tannous BA, Kim DE, Fernandez JL, Weissleder R, Breakefield XO.
Codon-optimized gaussia luciferase cDNA for Mammalian gene expression in culture and in vivo
Mol Ther. 2005;11(3):435-43 - PMID: 15727940
Reichardt W, Hu-Lowe D, Torres D, Weissleder R, Bogdanov A Jr.
Imaging of VEGF receptor kinase inhibitor-induced antiangiogenic effects in drug-resistant human adenocarcinoma model
Neoplasia. 2005;7(9):847-53 - PMID: 16229807 - PMCID: PMC1351316
Funovics M, Montet X, Reynolds F, Weissleder R, Josephson L.
Nanoparticles for the Optical Imaging of Tumor E-selectin
Neoplasia. 2005;7(10):904-11 - PMID: 16242073
Shinde Patil VR, Friedrich EB, Wolley AE, Gerszten RE, Allport JR, Weissleder R.
Bone Marrow-Derived lin(-)c-kit(+)Sca-1(+) Stem Cells Do Not Contribute to Vasculogenesis in Lewis Lung Carcinoma
Neoplasia. 2005;7(3):234-40 - PMID: 15799823 - PMCID: PMC1501134
Alencar H, Mahmood U, Kawano Y, Hirata T, Weissleder R
Novel Multiwavelength Microscopic Scanner for Mouse Imaging.
Neoplasia. 2005;7(11):977-983 - PMID: 16331883 - PMCID: PMC1502018
Tsourkas A, Newton G, Perez JM, Basilion J, Weissleder R.
Detection of Peroxidase-Mediated Dityrosine Formation with Enhanced Yellow Fluorescent Protein
Anal Chem. 2005;77:2862-2867 - PMID: 15859603
Kim DE, Jaffer FA, Weissleder R, Tung CH, Schellingerhout D.
Near-infrared fluorescent imaging of cerebral thrombi and blood-brain barrier disruption in a mouse model of cerebral venous sinus thrombosis
J Cerebr Blood F Met. 2005;25(2):226-33 - PMID: 15678125
Querol M, Chen JW, Weissleder R, Bogdanov A Jr.
DTPA-bisamide-Based MR Sensor Agents for Peroxidase Imaging
Org Lett. 2005;7(9):1719-22 - PMID: 15844889
Alencar H, King R, Funovics M, Stout C, Weissleder R, Mahmood U.
A novel mouse model for segmental orthotopic colon cancer
Int J Cancer. 2005;117(3):335-9 - PMID: 15900588
Figueiredo JL, Alencar H, Weissleder R, Mahmood U
Near infrared thoracoscopy of tumoral protease activity for improved detection of peripheral lung cancer.
Int J Cancer. 2005;118(11):2672-7 - PMID: 16380983
Hilderbrand SA, Kelly KA, Weissleder R, Tung CH.
Monofunctional near-infrared fluorochromes for imaging applications
Bioconjugate Chem. 2005;16(5):1275-81 - PMID: 16173808
Reynolds F, Weissleder R, Josephson L.
Protamine as an efficient membrane-translocating Peptide
Bioconjugate Chem. 2005;16(5):1240-5 - PMID: 16173804
Yuan H, Luo J, Field S, Weissleder R, Cantley L, Josephson L.
Synthesis and Activity of C11-Modified Wortmannin Probes for P13 Kinase
Bioconjugate Chem. 2005;(3):669-675 - PMID: 15898736
Tsourkas A, Shinde-Patil VR, Kelly KA, Patel P, Wolley A, Allport JR, Weissleder R.
In Vivo Imaging of Activated Endothelium Using an Anti-VCAM-1 Magneto optical Probe
Bioconjugate Chem. 2005;(3):576-581 - PMID: 15898724
Brown AB, Mahmood U, Cortes ML, Tang Y, Dai G, Stemmer-Rachamimov A, Prabhakar S, Leishear K, Onda H, Kwiatkowski D, Weissleder R, Breakefield X
Magnetic resonance imaging and characterization of spontaneous lesions in a transgenic mouse model of tuberous sclerosis as a model for endothelial cell-based transgene delivery.
Hum Gene Ther. 2005;16:1367-76 - PMID: 16390268
Shih HA, Harisinghani M, Zietman AL, Wolfgang JA, Saksena M, Weissleder R.
Mapping of nodal disease in locally advanced prostate cancer: Rethinking the clinical target volume for pelvic nodal irradiation based on vascular rather than bony anatomy
Int J Radiat Oncol Biol Phys. 2005;63(4):1262-9 - PMID: 16253781
Bremer C, Ntziachristos V, Weitkamp B, Theilmeier G, Heindel W, Weissleder R.
Optical Imaging of Spontaneous Breast Tumors Using Protease Sensing
Invest Radiol. 2005;(6):321-327 - PMID: 15905717
Choi HK, Yessayan D, Choi HJ, Schellenberger E, Bogdanov A, Josephson L, Weissleder R, Ntziachristos V.
Quantitative analysis of chemotherapeutic effects in tumors using in vivo staining and correlative histology
Cell Oncol. 2005;27(3):183-90 - PMID: 16037639
Chen WT, Mahmood U, Weissleder R, Tung CH
Arthritis imaging using a near-infrared fluorescence folate-targeted probe
Arthritis Res Ther. 2005;7:R310-R317 - PMID: 15743478 - PMCID: PMC1065321
Shah K, Weissleder R
Molecular Optical Imaging: Applications Leading to the Development of Present Day Therapeutics
NeuroRx. 2005;2:215-225 - PMID: 15897946 - PMCID: PMC1064987
Tung CH, Quinti L, Jaffer F, Weissleder R
A Branched Fluorescent Peptide Probe for Imaging of Activated Platelets
Mol Pharmacol. 2005;2:92-95 - PMID: 15804182
Law B, Weissleder R, Tung CH.
Mechanism-Based Fluorescent Reporter for Protein Kinase A Detection
Chembiochem. 2005;6(8):1361-1367 - PMID: 16010698
Koch AM, Reynolds F, Merkle HP, Weissleder R, Josephson L.
Transport Of Surface-Modified Nanoparticles Through Cell Monolayers
Chembiochem. 2005;6(2):337-345 - PMID: 15651046
Pivovarov M, Bhandary G, Mahmood U, Zahlmann G, Naraghi M, Weissleder R
MIPortal: A High Capacity Server for Molecular Imaging Research.
Mol Imaging. 2005;4(4):425-31 - PMID: 16285904
Chen WT, Khazaie K, Zhang G, Weissleder R, Tung CH
Detection of dysplastic intestinal adenomas using a fluorescent folate imaging probe
Mol Imaging. 2005;4 (1):67-74 - PMID: 15912902
Montet-Abou K, Montet X, Weissleder R, Josephson L.
Transfection agent induced nanoparticle cell loading
Mol Imaging. 2005;4(3):165-71 - PMID: 16194448
Gillies R, Hoffman J, Lam K, Menkens A, Piwnica-Worms D, Sullivan D, Weissleder R.
Meeting Report: High-Throughput Technologies for In Vivo Imaging Agents
Mol Imaging. 2005;4:1-6
Wunder A, Schellenberger E, Mahmood U, Bogdanov A Jr, Muller-Ladner U, Weissleder R, Josephson L.
Methotrexate-induced accumulation of fluorescent annexin v in collagen-induced arthritis
Mol Imaging. 2005;4(1):1-6 - PMID: 15967121
Zacharakis G, Ripoll J, Weissleder R, Ntziachristos V.
Fluorescent protein tomography scanner for small animal imaging
IEEE T Med Imaging. 2005;24(7):878-85 - PMID: 16011317
Galande A, Weissleder R, Tung CH.
An Effective Method of On-Resin Disulfide Bond Formation in Peptides
J Comb Chem. 2005;7:174-177 - PMID: 15762743
Sosnovik DE, Schellenberger EA, Nahrendorf M, Novikov MS, Matsui T, Dai G, Reynolds F, Grazette L, Rosenzweig A, Weissleder R, Josephson L.
Magnetic resonance imaging of cardiomyocyte apoptosis with a novel magneto-optical nanoparticle
Magn Reson Med. 2005;54(3):718-724 - PMID: 16086367
Graves EE, Yessayan D, Turner G, Weissleder R, Ntziachristos V.
Validation of in vivo fluorochrome concentrations measured using fluorescence molecular tomography
J Biomed Opt. 2005;10(4):44019 - PMID: 16178652
Law B, Hsiao JK, Bugge TH, Weissleder R, Tung CH.
Optical zymography for specific detection of urokinase plasminogen activator activity in biological samples
Anal Biochem. 2005;338(1):151-158 - PMID: 15707946
Querol Sans M*, Chen JW*, Weissleder R, Bogdanov AA
Myeloperoxidase Activity Imaging Using (67)Ga Labeled Substrate.
Mol Imaging Biol. 2005;:1-8 - PMID: 16292477
Reynolds F, O'loughlin T, Weissleder R, Josephson L.
Method of Determining Nanoparticle Core Weight
Anal Bioanal Chem. 2005;77(3):814-817 - PMID: 15679348
Zhu B, Jaffer F, Nztiachristos V, Weissleder R
Development of a near infrared fluorescence catheter: operating characteristics and feasibility for atherosclerotic plaque detection
J Phys D Appl Phys. 2005;38:2701-2707
Harisinghani MG, Saksena M, Ross RW, Tabatabaei S, Dahl D, McDougal S, Weissleder R
A pilot study of lymphotrophic nanoparticle-enhanced magnetic resonance imaging technique in early stage testicular cancer: a new method for noninvasive lymph node evaluation.
Urology. 2005;66(5):1066-71 - PMID: 16286125
Kim CF, Jackson EL, Kirsch DG, Grimm J, Shaw AT, Lane K, Kissil J, Olive KP, Sweet-Cordero A, Weissleder R, Jacks T
Mouse Models of Human Non-Small-Cell Lung Cancer: Raising the Bar.
Cold Spring Harb Symp Quant Biol. 2005;70:241-250 - PMID: 16869760
Sosnovik D, Weissleder R
Magnetic resonance and fluorescence based molecular imaging technologies.
Prog Drug Res. 2005;62:83-115 - PMID: 16329255
Bogdanov AA Jr, Chen JW, Kang HW, Weissleder R.
Magnetic resonance signal amplification probes
Ernst Schering Res Found Workshop. 2005;49:147-57 - PMID: 15524215
56
Jaffer FA, Tung CH, Wykrzykowska JJ, Ho NH, Houng AK, Reed GL, Weissleder R
Molecular Imaging of Factor XIIIa Activity in Thrombosis Using a Novel, Near-Infrared Fluorescent Contrast Agent That Covalently Links to Thrombi.
Circulation. 2004;110(2):170-6 - PMID: 15210587
Harisinghani MG, Weissleder R
Sensitive, noninvasive detection of lymph node metastases.
Tsourkas A, Hofstetter O, Hofstetter H, Weissleder R, Josephson L
Magnetic Relaxation Switch Immunosensors Detect Enantiomeric Impurities
Angew Chem Int Edit. 2004;43(18):2395-2399 - PMID: 15114571
Jaffer FA, Weissleder R
Seeing within: molecular imaging of the cardiovascular system
Circ Res. 2004;94(4):433-45 - PMID: 15001542
Perez JM, Simeone FJ, Tsourkas A, Josephson L, Weissleder R
Peroxidase substrate nanosensors for MR imaging
Nano Lett. 2004;4:119-122
Denis MC, Mahmood U, Benoist C, Mathis D, Weissleder R
Imaging inflammation of the pancreatic islets in type 1 diabetes.
Ntziachristos V, Schellenberger EA, Ripoll J, Yessayan D, Graves E, Bogdanov A Jr, Josephson L, Weissleder R
Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate.
Tung CH, Zeng Q, Shah K, Kim DE, Schellingerhout D, Weissleder R
In Vivo Imaging of ?-Galactosidase Activity Using Far Red Fluorescent Switch
Cancer Res. 2004;64:1579-1583 - PMID: 14996712
Grimm J, Perez JM, Josephson L, Weissleder R
Novel nanosensors for rapid analysis of telomerase activity
Cancer Res. 2004;64:639-43 - PMID: 14744779
Shah K, Tung CH, Yang K, Weissleder R, Breakefield XO
Inducible release of TRAIL fusion proteins from a proapoptotic form for tumor therapy
Cancer Res. 2004;64(9):3236-42 - PMID: 15126365
Kelly K, Alencar H, Funovics M, Mahmood U, Weissleder R
Detection of invasive colon cancer using a novel, targeted, library-derived fluorescent peptide.
Cancer Res. 2004;64(17):6247-51 - PMID: 15342411
Shah K, Tung CH, Chang CH, Slootweg E, O'Loughlin T, Breakefield XO, Weissleder R
In vivo imaging of HIV protease activity in amplicon vector-transduced gliomas
Cancer Res. 2004;64:273-8 - PMID: 14729634
Gondi CS, Lakka SS, Yanamandra N, Olivero WC, Dinh DH, Gujrati M, Tung CH, Weissleder R, Rao JS
Adenovirus-mediated expression of antisense urokinase plasminogen activator receptor and antisense cathepsin B inhibits tumor growth, invasion, and angiogenesis in gliomas.
Cancer Res. 2004;64(12):4069-77 - PMID: 15205313
Wunder A, Tung CH, Muller-Ladner U, Weissleder R, Mahmood U
In vivo imaging of protease activity in arthritis: a novel approach for monitoring treatment response.
Arth Rheum/AR C Res. 2004;50(8):2459-65 - PMID: 15334458
Zhao M, Weissleder R
Intracellular cargo delivery using tat peptide and derivatives
Med Res Rev. 2004;24:1-12 - PMID: 14595670
Kim DE, Schellingerhout D, Ishii K, Shah K, Weissleder R
Imaging of Stem Cell Recruitment to Ischemic Infarcts in a Murine Model
Stroke. 2004;35:952-7 - PMID: 14988578
Law B, Curino A, Bugge TH, Weissleder R, Tung CH
Design, synthesis, and characterization of urokinase plasminogen-activator-sensitive near-infrared reporter.
Chem Biol. 2004;11(1):99-106 - PMID: 15112999
Messerli SM, Prabhakar S, Tang Y, Shah K, Cortes ML, Murthy V, Weissleder R, Breakefield XO, Tung CH
A novel method for imaging apoptosis using a caspase-1 near-infrared fluorescent probe.
Neoplasia. 2004;6(2):95-105 - PMID: 15140398 - PMCID: PMC1502090
Funovics MA, Weissleder R, Mahmood U
Catheter-based in vivo imaging of enzyme activity and gene expression: feasibility study in mice.
Radiology. 2004;231(3):659-66 - PMID: 15163807
Shah K, Jacobs A, Breakefield XO, Weissleder R
Molecular imaging of gene therapy for cancer
Gene Ther. 2004;11(15):1175-87 - PMID: 15141158
Graves EE, Weissleder R, Ntziachristos V
Fluorescence molecular imaging of small animal tumor models.
Curr Mol Med. 2004;4(4):419-30 - PMID: 15354872
Kircher MF, Weissleder R, Josephson L
A dual fluorochrome probe for imaging proteases
Bioconjugate Chem. 2004;15:242-8 - PMID: 15025519
Pham W, Choi Y, Weissleder R, Tung CH
Developing a Peptide-Based Near-Infrared Molecular Probe for Protease Sensing.
Bioconjugate Chem. 2004;15(6):1403-1407 - PMID: 15546208
Banerjee P, Reichardt W, Weissleder R, Bogdanov A Jr
Novel hyperbranched dendron for gene transfer in vitro and in vivo.
Bioconjugate Chem. 2004;15(5):960-8 - PMID: 15366948
Metelev V, Weissleder R, Bogdanov A Jr
Synthesis and Properties of Fluorescent NF-kappaB-Recognizing Hairpin Oligodeoxyribonucleotide Decoys.
Bioconjugate Chem. 2004;15(6):1481-1487 - PMID: 15546218
Schellenberger EA, Sosnovik D, Weissleder R, Josephson L
Magneto/Optical annexin v, a multimodal protein.
Bioconjugate Chem. 2004;15(5):1062-7 - PMID: 15366960
Pham W, Kircher MF, Weissleder R, Tung CH
Enhancing membrane permeability by Fatty acylation of oligoarginine peptides.
Chembiochem. 2004;5(8):1148-51 - PMID: 15300843
Perez JM, Josephson L, Weissleder R
Use of magnetic nanoparticles as nanosensors to probe for molecular interactions
Chembiochem. 2004;5:261-4 - PMID: 14997516
Schellenberger EA, Reynolds F, Weissleder R, Josephson L
Surface-functionalized nanoparticle library yields probes for apoptotic cells
Chembiochem. 2004;5:275-9 - PMID: 14997519
Schellenberger EA, Weissleder R, Josephson L
Optimal modification of annexin v with fluorescent dyes
Chembiochem. 2004;5:271-4 - PMID: 14997518
Chen WT, Tung CH, Weissleder R
Imaging reactive oxygen species in arthritis.
Mol Imaging. 2004;3(3):159-62 - PMID: 15530251
Chen JW, Pham W, Weissleder R, Bogdanov A Jr
Human myeloperoxidase: A potential target for molecular MR imaging in atherosclerosis.
Magn Reson Med. 2004;52(5):1021-8 - PMID: 15508166
Kim YR, Savellano MD, Savellano DH, Weissleder R, Bogdanov A Jr
Measurement of tumor interstitial volume fraction: Method and implication for drug delivery
Magn Reson Med. 2004;52(3):485-94 - PMID: 15334566
Kelly KA, Reynolds F, Weissleder R, Josephson L
Fluorescein isothiocyanate-hapten immunoassay for determination of peptide-cell interactions.
Anal Biochem. 2004;330(2):181-5 - PMID: 15203322
Allport JR, Shinde Patil VR, Weissleder R
Murine Neuronal Progenitor Cells are Preferentially Recruited to Tumor Vasculature via alpha(4)-integrin and SDF-1alpha-Dependent Mechanisms.
Cancer Biol Ther. 2004;3(9):838-44 - PMID: 15254391
Graves EE, Culver JP, Ripoll J, Weissleder R, Ntziachristos V
Singular-value analysis and optimization of experimental parameters in fluorescence molecular tomography
J Opt Soc Am A . 2004;21(2):231-41 - PMID: 14763766
Tsourkas A, Weissleder R
Illuminating the dynamics of intracellular activity with
Mech Chem Biosyst. 2004;1:133-45 - PMID: 16783939
37
Harisinghani MG, Barentsz J, Hahn PF, Deserno WM, Tabatabaei S, van de Kaa CH, de la Rosette J, Weissleder R
Noninvasive detection of clinically occult lymph-node metastases in prostate cancer
New Engl J Med. 2003;348:2491-9 - PMID: 12815134
Weissleder R, Ntziachristos V
Shedding light onto live molecular targets
Nat Med. 2003;9:123-8 - PMID: 12514725
Rudin M, Weissleder R
Molecular imaging in drug discovery and development
Nat Rev Drug Discov. 2003;2:123-31 - PMID: 12563303
Zhao M, Josephson L, Tang Y, Weissleder R
Magnetic sensors for protease assays
Angew Chem Int Edit. 2003;42:1375-8 - PMID: 12671972
Tung CH, Weissleder R
Arginine containing peptides as delivery vectors
Adv Drug Deliv Rev. 2003;55:281-94 - PMID: 12564981
Perez JM, Simeone FJ, Saeki Y, Josephson L, Weissleder R
Viral-induced self-assembly of magnetic nanoparticles allows the detection of viral particles in biological media
J Am Chem Soc. 2003;125:10192-3 - PMID: 12926940
Kircher MF, Allport, JR, Graves EE, Love V, Josephson L, Lichtman AH, Weissleder R
In vivo high resolution three-dimensional imaging of antigen-specific cytotoxic T-lymphocyte trafficking to tumors
Cancer Res. 2003;63:6838-46 - PMID: 14583481
Kircher MF, Mahmood U, King RS, Weissleder R, Josephson L
A multimodal nanoparticle for preoperative magnetic resonance imaging and intraoperative optical brain tumor delineation
Cancer Res. 2003;63:8122-5 - PMID: 14678964
Petrovsky A, Schellenberger E, Josephson L, Weissleder R, Bogdanov A Jr
Near-infrared fluorescent imaging of tumor apoptosis
Cancer Res. 2003;63:1936-42 - PMID: 12702586
Shah K, Tang Y, Breakefield X, Weissleder R
Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo
Oncogene. 2003;22:6865-72 - PMID: 14534533
Schellenberger EA, Bogdanov A Jr, Petrovsky A, Ntziachristos V, Weissleder R, Josephson L
Optical imaging of apoptosis as a biomarker of tumor response to chemotherapy
Neoplasia. 2003;5:187-92 - PMID: 12869301 - PMCID: PMC1502408
Hogemann-Savellano D, Bos E, Blondet C, Sato F, Abe T, Josephson L, Weissleder R, Gaudet J, Sgroi D, Peters PJ, Basilion JP.
The transferrin receptor: a potential molecular imaging marker for human cancer.
Neoplasia. 2003;5(6):495-506 - PMID: 14965443 - PMCID: PMC1502574
Allport JR, Weissleder R
Murine Lewis lung carcinoma-derived endothelium expresses markers of endothelial activation and requires tumor-specific extracellular matrix in vitro
Neoplasia. 2003;5:205-17 - PMID: 12869304 - PMCID: PMC1502407
Bremer C, Mustafa M, Bogdanov A Jr, Ntziachristos V, Petrovsky A, Weissleder R
Steady-state blood volume measurements in experimental tumors with different angiogenic burdens a study in mice
Radiology. 2003;226:214-20 - PMID: 12511693
Mahmood U, Weissleder R
Near-infrared optical imaging of proteases in cancer
Mol Cancer Ther. 2003;2:489-96 - PMID: 12748311
Moon, WK, Lin Y, O'Loughlin T, Tang Y, Kim DE, Weissleder R, Tung CH
Enhanced tumor detection using a folate receptor-targeted near-infrared fluorochrome conjugate
Bioconjugate Chem. 2003;14:539-45 - PMID: 12757377
Koch AM, Reynolds F, Kircher MF, Merkle HP, Weissleder R, Josephson L
Uptake and metabolism of a dual fluorochrome Tat-nanoparticle in HeLa cells
Bioconjugate Chem. 2003;14:1115-21 - PMID: 14624624
Pham W, Lai WF, Weissleder R, Tung CH
High efficiency synthesis of a bioconjugatable near-infrared fluorochrome
Bioconjugate Chem. 2003;14:1048-51 - PMID: 13129411
Tang Y, Shah K, Messerli SM, Snyder E, Breakefield X, Weissleder R
In vivo tracking of neural progenitor cell migration to glioblastomas
Hum Gene Ther. 2003;14:1247-54 - PMID: 12952596
Simonova M, Shtanko O, Sergeyev N, Weissleder R, Bogdanov A Jr
Engineering of technetium-99m-binding artificial receptors for imaging gene expression
J Gene Med. 2003;5:1056-66 - PMID: 14661181
Tung CH, Ho NH, Zeng Q, Tang Y, Jaffer FA, Reed GL, Weissleder R
Novel Factor XIII Probes for Blood Coagulation Imaging
Chembiochem. 2003;4:897-899 - PMID: 12964167
Lin Y, Weissleder R, Tung CH
Synthesis and properties of sulfhydryl-reactive near-infrared cyanine fluorochromes for fluorescence imaging
Mol Imaging. 2003;2:87-92 - PMID: 12964306
Moffat BA, Reddy GR, McConville P, Hall DE, Chenevert TL, Kopelman RR, Philbert M, Weissleder R, Rehemtulla A, Ross BD
A novel polyacrylamide magnetic nanoparticle contrast agent for molecular imaging using MRI
Mol Imaging. 2003;2:324-32 - PMID: 14717331
Josephson L, Mahmood U, Wunderbaldinger P, Tang Y, Weissleder R
Pan and sentinel lymph node visualization using a near-infrared fluorescent probe
Mol Imaging. 2003;2:18-23 - PMID: 12926234
Funovics MA, Alencar H, Su HS, Khazaie K, Weissleder R, Mahmood U
Miniaturized multichannel near infrared endoscope for mouse imaging
Mol Imaging. 2003;2:350-7 - PMID: 14717334
Graves EE, Ripoll J, Weissleder R, Ntziachristos V
A submillimeter resolution fluorescence molecular imaging system for small animal imaging
Med Phys. 2003;30:901-11 - PMID: 12772999
Funovics M, Weissleder R, Tung CH
Protease sensors for bioimaging
Anal Bioanal Chem. 2003;377:956-63 - PMID: 12955390
Ntziachristos V, Bremer C, Weissleder R
Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging
Eur J Radiol. 2003;13:195-208 - PMID: 12541130
Bremer C, Ntziachristos V, Weissleder R
Optical-based molecular imaging: contrast agents and potential medical applications
Eur J Radiol. 2003;13:231-43 - PMID: 12598985
Yip S, Aboody KS, Burns M, Imitola J, Boockvar JA, Allport J, Park KI, Teng YD, Lachyankar M, McIntosh T, O'Rourke DM, Khoury S, Weissleder R, Black PM, Weiss W, Snyder EY
Neural stem cell biology may be well suited for improving brain tumor therapies
Cancer J. 2003;9:189-204 - PMID: 12952304
30
Weissleder R
Scaling down imaging: molecular mapping of cancer in mice
Nat Rev Cancer. 2002;2:1-8 - PMID: 11902581
Ntziachristos V, Tung CH, Bremer C, Weissleder R
Fluorescence molecular tomography resolves protease activity in vivo
Nat Med. 2002;8:757-60 - PMID: 12091907
Bachoo RM, Maher EA, Ligon KL, Sharpless NE, Chan SS, You MJ, Tang Y, DeFrances J, Stover E, Weissleder R, Rowitch DH, Louis DN, DePinho RA
Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis
Cancer Cell. 2002;1:269-77 - PMID: 12086863
Perez JM, Josephson L, O'Loughlin T, Hogemann D, Weissleder R
Magnetic relaxation switches capable of sensing molecular interactions
Nat Biotechnol. 2002;20:816-20 - PMID: 12134166
Ji H, Ohmura K, Mahmood U, Lee DM, Hofhuis FM, Boackle SA, Takahashi K, Holers VM, Walport M, Gerard C, Ezekowitz A, Carroll MC, Brenner M, Weissleder R, Verbeek JS, Duchatelle V, Degott C, Benoist C, Mathis D
Arthritis critically dependent on innate immune system players
Immunity. 2002;16:157-68 - PMID: 11869678
Chen J, Tung CH, Mahmood U, Ntziachristos V, Gyurko R, Fishman MC, Huang PL, Weissleder R
In vivo imaging of proteolytic activity in atherosclerosis
Circulation. 2002;105:2766-71 - PMID: 12057992
Marten K, Bremer C, Khazaie K, Sameni M, Sloane B, Tung CH, Weissleder R
Detection of dysplastic intestinal adenomas using enzyme-sensing molecular beacons in mice
Gastroenterology. 2002;122:406-14 - PMID: 11832455
Pham W, Weissleder R, Tung CH
An azulene dimer as a near-infrared quencher
Angew Chem Int Edit. 2002;41:3659-62, 3519 - PMID: 12370922
Perez JM, O'Loughin T, Simeone F J, Weissleder R, Josephson L
DNA-based magnetic nanoparticle assembly acts as a magnetic relaxation nanoswitch allowing screening of DNA-cleaving agents
J Am Chem Soc. 2002;124:2856-7 - PMID: 11902860
Jaffer FA, Tung CH, Gerszten RE, Weissleder R
In vivo imaging of thrombin activity in experimental thrombi with thrombin-sensitive near-infrared molecular probe
Arterioscler Thromb Vasc Biol. 2002;22:1929-35 - PMID: 12426227
Ichikawa T, Hogemann D, Saeki Y, Tyminski E, Terada K, Weissleder R, Chiocca EA, Basilion JP
MRI of transgene expression: correlation to therapeutic gene expression
Neoplasia. 2002;4:523-30 - PMID: 12407446 - PMCID: PMC1503666
Messerli SM, Tang Y, Giovannini M, Bronson R, Weissleder R, Breakefield XO
Detection of spontaneous schwannomas by MRI in a transgenic murine model of neurofibromatosis type 2
Neoplasia. 2002;4:501-9 - PMID: 12407444 - PMCID: PMC1503664
Melder RJ, Munn LL, Stoll BR, Marecos EM, Baxter LT, Weissleder R, Jain RK
Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic model
Neoplasia. 2002;4:3-8 - PMID: 11922388 - PMCID: PMC1503314
Bogdanov AA Jr, Lin CP, Simonova M, Matuszewski L, Weissleder R
Cellular activation of the self-quenched fluorescent reporter probe in tumor microenvironment
Neoplasia. 2002;4:228-36 - PMID: 11988842 - PMCID: PMC1531696
Bremer C, Tung CH, Bogdanov A Jr, Weissleder R
Imaging of differential protease expression in breast cancers for detection of aggressive tumor phenotypes
Radiology. 2002;222:814-8 - PMID: 11867806
Mahmood U, Tung CH, Tang Y, Weissleder R
Feasibility of in vivo multichannel optical imaging of gene expression: experimental study in mice
Radiology. 2002;224:446-51 - PMID: 12147841
Lin Y, Weissleder R, Tung CH
Novel near-infrared cyanine fluorochromes: synthesis, properties, and bioconjugation
Bioconjugate Chem. 2002;13:605-10 - PMID: 12009952
Hogemann D, Ntziachristos V, Josephson L, Weissleder R
High throughput magnetic resonance imaging for evaluating targeted nanoparticle probes
Bioconjugate Chem. 2002;13:116-21 - PMID: 11792186
Kang HW, Josephson L, Petrovsky A, Weissleder R, Bogdanov A Jr
Magnetic resonance imaging of inducible E-selectin expression in human endothelial cell culture
Bioconjugate Chem. 2002;13:122-7 - PMID: 11792187
Wunderbaldinger P, Josephson L, Weissleder R
Tat peptide directs enhanced clearance and hepatic permeability of magnetic nanoparticles
Bioconjugate Chem. 2002;13:264-8 - PMID: 11906263
Josephson L, Kircher MF, Mahmood U, Tang Y, Weissleder R
Near-infrared fluorescent nanoparticles as combined MR/optical imaging probes
Bioconjugate Chem. 2002;13:554-60 - PMID: 12009946
Zhao M, Kircher MF, Josephson L, Weissleder R
Differential conjugation of tat peptide to superparamagnetic nanoparticles and its effect on cellular uptake
Bioconjugate Chem. 2002;13:840-4 - PMID: 12121140
Tung CH, Lin Y, Moon WK, Weissleder R
A receptor-targeted near-infrared fluorescence probe for in vivo tumor imaging
Chembiochem. 2002;3:784-6 - PMID: 12203978
Tung CH, Gerszten RE, Jaffer FA, Weissleder R
A novel near-infrared fluorescence sensor for detection of thrombin activation in blood
Chembiochem. 2002;3:207-11 - PMID: 11921399
Schellingerhout D, Accorsi R, Mahmood U, Idoine J, Lanza RC, Weissleder R
Coded aperture nuclear scintigraphy: a novel small animal imaging technique
Mol Imaging. 2002;1:344-53 - PMID: 12926230
Bogdanov A Jr, Matuszewski L, Bremer C, Petrovsky A, Weissleder R
Oligomerization of paramagnetic substrates result in signal amplification and can be used for MR imaging of molecular targets
Mol Imaging. 2002;1:16-23 - PMID: 12920857
Schellenberger EA, Bogdanov A Jr, Hogemann D, Tait J, Weissleder R, Josephson L
Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI
Mol Imaging. 2002;1:102-7 - PMID: 12920851
Kircher MF, Josephson L, Weissleder R
Ratio imaging of enzyme activity using dual wavelength optical reporters
Mol Imaging. 2002;1:89-95 - PMID: 12920849
Ntziachristos, V, Bremer C, Graves EE, Ripoll J, Weissleder R
In vivo tomographic imaging of near-infrared fluorescent probes
Mol Imaging. 2002;1:82-8 - PMID: 12920848
Ntziachristos V, Weissleder R
Charge-coupled-device based scanner for tomography of fluorescent near-infrared probes in turbid media
Med Phys. 2002;29:803-9 - PMID: 12033576
Moore, A, Sun PZ, Cory D, Hogemann D, Weissleder R, Lipes MA
MRI of insulitis in autoimmune diabetes
Magn Reson Med. 2002;47:751-8 - PMID: 11948737
Wunderbaldinger P, Josephson L, Bremer C, Moore A, Weissleder R
Detection of lymph node metastases by contrast-enhanced MRI in an experimental model
Magn Reson Med. 2002;47:292-7 - PMID: 11810672
Kang HW, Weissleder R, Bogdanov A Jr
Targeting of MPEG-protected polyamino acid carrier to human E-selectin in vitro
Amino Acids. 2002;23:301-8 - PMID: 12373551
Tung CH, Mueller S, Weissleder R
Novel branching membrane translocational peptide as gene delivery vector
Bioorg Med Chem. 2002;10:3609-14 - PMID: 12213476
Kim YR, Savellano MD, Weissleder R, Bogdanov A Jr
Steady-state and dynamic contrast MR imaging of human prostate cancer xenograft tumors: a comparative study
Technol Cancer Res T. 2002;1:489-95 - PMID: 12625776
Harisinghani MG, Barentsz JO, Hahn PF, Deserno W, de la Rosette J, Saini S, Marten K, Weissleder R
MR lymphangiography for detection of minimal nodal disease in patients with prostate cancer
Acad Radiol. 2002;9 Suppl 2:S312-3 - PMID: 12188258
Bremer C, Tung CH, Weissleder R
Molecular imaging of MMP expression and therapeutic MMP inhibition
Acad Radiol. 2002;9 Suppl 2:S314-5 - PMID: 12188259
Mahmood U, Weissleder R
Some tools for molecular imaging
Acad Radiol. 2002;9:629-31 - PMID: 12061735
Ntziachristos, V, Bremer C, Tung C, Weissleder R
Imaging cathepsin B up-regulation in HT-1080 tumor models using fluorescence-mediated molecular tomography (FMT)
Acad Radiol. 2002;9 Suppl 2:S323-5 - PMID: 12188262
Wunderbaldinger P, Josephson L, Weissleder R
Crosslinked iron oxides (CLIO): a new platform for the development of targeted MR contrast agents
Acad Radiol. 2002;9 Suppl 2:S304-6 - PMID: 12188255
Schellenberger EA, Hogemann D, Josephson L, Weissleder R
Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI
Acad Radiol. 2002;9 Suppl 2:S310-1 - PMID: 12188257
41
Bremer C, Tung CH, Weissleder R
In vivo molecular target assessment of matrix metalloproteinase inhibition
Nat Med. 2001;7:743-8 - PMID: 11385514
Moore A, Bonner-Weir S, Weissleder R
Noninvasive in vivo measurement of beta-cell mass in mouse model of diabetes
Diabetes. 2001;50:2231-6 - PMID: 11574403
Bremer C, Bredow S, Mahmood U, Weissleder R, Tung CH
Optical imaging of matrix metalloproteinase-2 activity in tumors: feasibility study in a mouse model
Radiology. 2001;221:523-9 - PMID: 11687699
Moore A, Josephson L, Bhorade RM, Basilion JP, Weissleder R
Human transferrin receptor gene as a marker gene for MR imaging
Radiology. 2001;221:244-50 - PMID: 11568347
Bogdanov A Jr, Tung CH, Bredow S, Weissleder R
DNA binding chelates for nonviral gene delivery imaging
Gene Ther. 2001;8:515-22 - PMID: 11319618
Weissleder R, Bogdanov A Jr, Tung CH, Weinmann HJ
Size optimization of synthetic graft copolymers for in vivo angiogenesis imaging
Bioconjugate Chem. 2001;12:213-9 - PMID: 11312682
Spear MA, Breakefield XO, Beltzer J, Schuback D, Weissleder R, Pardo FS, Ladner R
Isolation, characterization, and recovery of small peptide phage display epitopes selected against viable malignant glioma cells
Cancer Gene Ther. 2001;8:506-11 - PMID: 11498772
Allport JR, Weissleder R
In vivo imaging of gene and cell therapies
Exp Hematol. 2001;29:1237-46 - PMID: 11698119
O'Neill MJ, Weissleder R, Gervais DA, Hahn PF, Mueller PR
Tunneled peritoneal catheter placement under sonographic and fluoroscopic guidance in the palliative treatment of malignant ascites
Am J Roentgenol. 2001;177:615-8 - PMID: 11517056
Wagenaar DJ, Weissleder R, Hengerer A
Glossary of molecular imaging terminology
Acad Radiol. 2001;8:409-20 - PMID: 11345272
Bremer C, Weissleder R
In vivo imaging of gene expression
Acad Radiol. 2001;8:15-23 - PMID: 11201452
Dodd CH, Hsu HC, Chu WJ, Yang P, Zhang HG, Mountz JD Jr, Zinn K, Forder J, Josephson L, Weissleder R, Mountz JM, Mountz JD
Normal T-cell response and in vivo magnetic resonance imaging of T cells loaded with HIV transactivator-peptide-derived superparamagnetic nanoparticles
J Immunol Methods. 2001;256:89-105 - PMID: 11516758
Harisinghani MG, Saini S, Weissleder R, Rubin D, deLange E, Harms S, Weinreb J, Small W, Sukerkar A, Brown JJ, Zelch J, Lucas M, Morris M, Hahn PF
Splenic imaging with ultrasmall superparamagnetic iron oxide ferumoxtran-10 (AMI-7227): preliminary observations
J Comput Assist Tomo. 2001;25:770-6 - PMID: 11584239
Harisinghani MG, Jhaveri KS, Weissleder R, Schima W, Saini S, Hahn PF, Mueller PR
MRI contrast agents for evaluating focal hepatic lesions
Clin Radiol. 2001;56:714-25 - PMID: 11585393
Wunderbaldinger P, Weissleder R
[Experimental and clinical approaches to lymph node imaging]
Radiologe. 2001;41:121-30 - PMID: 11253097
Hogemann D, Basilion JP, Weissleder R
[Molecular imaging in magnetic resonance tomography and nuclear medicine]
Radiologe. 2001;41:116-20 - PMID: 11253096
Bremer C, Ntziachristos V, Mahmood U, Tung CH, Weissleder R
[Progress in optical imaging]
Radiologe. 2001;41:131-7 - PMID: 11253098
Bremer C, Bogdanov AA, Weissleder R
[Imaging of angiogenesis]
Radiologe. 2001;41:138-45 - PMID: 11253099
21
Weissleder R, Moore A, Mahmood U, Bhorade R, Benveniste H, Chiocca EA, Basilion JP
In vivo magnetic resonance imaging of transgene expression
Nat Med. 2000;6:351-5 - PMID: 10700241
Lewin M, Carlesso N, Tung CH, Tang XW, Cory D, Scadden DT, Weissleder R
Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells
Nat Biotechnol. 2000;18:410-4 - PMID: 10748521
Simonova M, Wall A, Weissleder R, Bogdanov A Jr
Tyrosinase mutants are capable of prodrug activation in transfected nonmelanotic cells
Cancer Res. 2000;60:6656-62 - PMID: 11118049
Tung CH, Mahmood U, Bredow S, Weissleder R
In vivo imaging of proteolytic enzyme activity using a novel molecular reporter
Cancer Res. 2000;60:4953-8 - PMID: 10987312
Moore A, Marecos E, Bogdanov A Jr, Weissleder R
Tumoral distribution of long-circulating dextran-coated iron oxide nanoparticles in a rodent model
Radiology. 2000;214:568-74 - PMID: 10671613
Schellingerhout D, Rainov NG, Breakefield XO, Weissleder R
Quantitation of HSV mass distribution in a rodent brain tumor model
Gene Ther. 2000;7:1648-55 - PMID: 11083473
Bredow S, Lewin M, Hofmann B, Marecos E, Weissleder R
Imaging of tumour neovasculature by targeting the TGF-beta binding receptor endoglin
Eur J Cancer. 2000;36:675-81 - PMID: 10738134
Hogemann D, Josephson L, Weissleder R, Basilion JP
Improvement of MRI probes to allow efficient detection of gene expression
Bioconjugate Chem. 2000;11:941-6 - PMID: 11087345
Bhorade R, Weissleder R, Nakakoshi T, Moore A, Tung CH
Macrocyclic chelators with paramagnetic cations are internalized into mammalian cells via a HIV-tat derived membrane translocation peptide
Bioconjugate Chem. 2000;11:301-5 - PMID: 10821645
Bogdanov AA Jr, Simonova M, Weissleder R
Engineering membrane proteins for nuclear medicine: applications for gene therapy and cell tracking
Q J Nucl Med Mol IM. 2000;44:224-35 - PMID: 11105587
Wunderbaldinger P, Bogdanov A, Weissleder R
New approaches for imaging in gene therapy
Eur J Radiol. 2000;34:156-65 - PMID: 10927158
11
Weissleder R, Tung CH, Mahmood U, Bogdanov A Jr
In vivo imaging of tumors with protease-activated near-infrared fluorescent probes
Nat Biotechnol. 1999;17:375-8 - PMID: 10207887
Bogdanov AA, Lewin M, Weissleder R
Approaches and agents for imaging the vascular system
Adv Drug Deliv Rev. 1999;37:279-293 - PMID: 10837740
Zaharchuk G, Mandeville JB, Bogdanov AA Jr, Weissleder R, Rosen BR, Marota JJ
Cerebrovascular dynamics of autoregulation and hypoperfusion. An MRI study of CBF and changes in total and microvascular cerebral blood volume during hemorrhagic hypotension
Stroke. 1999;30:2197-204; discussion 2204-5 - PMID: 10512929
Bogdanov A Jr, Marecos E, Cheng HC, Chandrasekaran L, Krutzsch HC, Roberts DD, Weissleder R
Treatment of experimental brain tumors with trombospondin-1 derived peptides: an in vivo imaging study
Neoplasia. 1999;1:438-45 - PMID: 10933059 - PMCID: PMC1508110
Mahmood U, Tung CH, Bogdanov A Jr, Weissleder R
Near-infrared optical imaging of protease activity for tumor detection
Radiology. 1999;213:866-70 - PMID: 10580968
Weissleder R
Molecular imaging: exploring the next frontier
Radiology. 1999;212:609-14 - PMID: 10478223
Lewin M, Bredow S, Sergeyev N, Marecos E, Bogdanov A Jr, Weissleder R
In vivo assessment of vascular endothelial growth factor-induced angiogenesis
Int J Cancer. 1999;83:798-802 - PMID: 10597197
Josephson L, Tung CH, Moore A, Weissleder R
High-efficiency intracellular magnetic labeling with novel superparamagnetic-Tat peptide conjugates
Bioconjugate Chem. 1999;10:186-91 - PMID: 10077466
Tung CH, Bredow S, Mahmood U, Weissleder R
Preparation of a cathepsin D sensitive near-infrared fluorescence probe for imaging
Bioconjugate Chem. 1999;10:892-6 - PMID: 10502358
Simonova M, Weissleder R, Sergeyev N, Vilissova N, Bogdanov A Jr
Targeting of green fluorescent protein expression to the cell surface
Biochem Bioph Res Co. 1999;262:638-42 - PMID: 10471377
Harisinghani MG, Saini S, Weissleder R, Hahn PF, Yantiss RK, Tempany C, Wood BJ, Mueller PR
MR lymphangiography using ultrasmall superparamagnetic iron oxide in patients with primary abdominal and pelvic malignancies: radiographic-pathologic correlation
Am J Roentgenol. 1999;172:1347-51 - PMID: 10227514
Schima W, Saini S, Petersein J, Weissleder R, Harisinghani M, Mayo-Smith W, Hahn PF
MR imaging of the liver with Gd-BOPTA: quantitative analysis of T1-weighted images at two different doses
J Magn Reson Imaging. 1999;10:80-3 - PMID: 10398981
Hofmann, B, Bogdanov A Jr, Marecos E, Ebert W, Semmler W, Weissleder R
Mechanism of gadophrin-2 accumulation in tumor necrosis
J Magn Reson Imaging. 1999;9:336-41 - PMID: 10077034
Enochs WS, Harsh G, Hochberg F, Weissleder R
Improved delineation of human brain tumors on MR images using a long-circulating, superparamagnetic iron oxide agent
J Magn Reson Imaging. 1999;9:228-32 - PMID: 10077018
14
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Ralph Weissleder, MD, PhD