Imaging Probes

The CMIR Chemistry core has developed a number of innovative materials for molecular imaging. Some of these materials are made available to the university based scientific community for experimental (non-human) use.

Compound MTA Cost Availability
MION-46 required NA discontinued
MION-47 required $300/20 mg
$1500/100 mg 		yes
MION-48 (high relaxivity) required NA collaborations only
CLIO-47 required NA collaborations only
 
MION-47 is a prototype monocrystalline iron oxide nanoparticle with an average diameter of 20-25 nm as determined by laser light scattering. The R1 and R2 values are approximately 29 and 60 mMsec-1 (0.47T, 39°C). MION-47 has been used for fMRI, as a vascular imaging agent and to measure macrophage activity in a number of diseases.
  • Biological properties: Bioconjug Chem. 2002;13:264-8
  • Angiogenesis: Radiology. 2003;226:214-20
  • Inflammation: PNAS 2004;101:12634-12639
  • fMRI: Neuroimage. 2002;16:283-94.
MION-48 is similar to MION-47 but has R2 values of approximately 120 mMsec-1 (0.47T, 39°C).
 
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