Overview

On this page we present an overview of recent research projects of the Clinical Imaging Program at the Center for Molecular Imaging Research:

Ongoing clinical projects

Angiogenesis imaging in primary breast cancer


Alex R. Guimaraes, MD, PhD; Mukesh G Harisinghani, MD; Ralph Weissleder, MD, PhD

The overall goal of this proposal is to correlate signal intensity changes in primary breast cancer following nanoparticle administration with distribution of microvessel density.

Status:Open for enrollment
Type of trial:Prospective
imaging, pathology correlation
Collaborators:Alphonse Taghian, MD,PhD
Michele Gadd, MD
Funding:MGH internally funded
Publications:NA (ongoing trial)

Imaging microvasculature in type 1 diabetes

Mukesh G Harisinghani, MD; Alex R. Guimaraes, MD, PhD; Ralph Weissleder, MD, PhD; Umar Mahmood MD, PhD

The overall aim of this component of the program is to explore the ability of MRI scans using MIONs to detect vascular changes associated with insulitis in patients with Type 1 diabetes.

Status:Ongoing
Type of trial:Clinical
Collaborators:Christophe Benoist, MD
Richard Jackson, MD
Diane Mathis, PhD
Funding:NIAID PPG
Publications:NA (ongoing trial)

Clinical trials in planning

F-18 NaF PET for Detection of Bone Metastases in Men with Prostate Cancer

Bone mets trial

Ralph Weissleder, MD, PhD; Mukesh G Harisinghani, MD

The overall goal of this proposal is to improve the staging of advanced prostate cancer by detecting the presence of bony metastases using a non-invasive technique.

Status:Not open yet
Type of trial:Clinical
Collaborators:Matthew R Smith,MD, PhD
Funding:NCI
Publications:NA (ongoing trial)

Preoperative staging of pancreatic cancer

Ralph Weissleder, MD, PhD; Mukesh G Harisinghani, MD

To improve the pre-operative staging of potentially resectable pancreatic cancers by detecting the presence of lymph node metastases using a non-invasive technique.

Status:Not open yet
Type of trial:Clinical
Collaborators:Andrew L Warshaw,MD
Funding:NCI GI-spore program
Publications:NA

Completed clinical trials

Nodal staging in breast cancer

Micromet

Mukesh Harisinghani, MD

The overall goal of this proposal is to extend the validated and novel approach to detecting cancer in lymph nodes of patients with breast cancer.

Status: Open for enrollment
Type of trial: Prospective
imaging, histopathology correlation
Collaborators: Alphonse Taghian, MD,PhD
Daniel B Kopans, MD
Michele Gadd, MD
Elizabeth Rafferty, MD
Alex R. Guimaraes, MD, PhD
Funding: Advanced Magnetics Inc., Cambridge / Breast Cancer Research Foundation
Publications: NA (ongoing trial)

Detection of minimal disease in lymph nodes from prostate cancer spread

Mukesh G Harisinghani, MD

The long-term goal of this research is to investigate and correlate histologically the MR signal intensity patterns of ultrasmall superparamagnetic iron oxide (USPIO) in patients with adenocarcinoma of prostate.

Status:Completed
Type of trial:Prospective
imaging pathology correlation
Collaborators:Scott W McDougal, MD
Shahin Tabatabei, MD
Donald Kaufman, MD
Anthony L Zietman, MD
Jelle Berentz, MD
Funding:RSNA Seed Grant
Publications:Harisinghani M, Weissleder R. Sensitive, Noninvasive Detection of Lymph Node Metastases. PLoS Med 2004; 1:e66.

Detection of minimal nodal disease in patients with primary genitourinary malignancies (renal, testicular, bladder, penis)

Mukesh G Harisinghani, MD

The long-term goal of this research is to investigate and correlate histologically the MR signal intensity patterns of ultrasmall superparamagnetic iron oxide (USPIO) in patients with adenocarcinoma of prostate.

Status:Completed
Type of trial:Prospective
imaging pathology correlation
Collaborators:Scott W McDougal, MD
Shahin Tabatabei, MD
Donald Kaufman, MD
Anthony L Zietman, MD
Jelle Berentz, MD
Funding:Advanced Magnetics Inc.
Publications:Harisinghani, M. G., Barentsz, J., Hahn, P. F., Deserno, W. M., Tabatabaei, S., van de Kaa, C. H., de la Rosette, J., and Weissleder, R. Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N Engl J Med, 348: 2491-9, 2003.
Deserno W, Harisinghani M, Taupitz M, Jager G, Witjes JA, Mulders PF, Hulsbergen CA, Kaufman D, Barentsz J. Urinary bladder cancer: preoperative nodal staging with ferumoxtran-10 enhanced MR imaging. Radiology 2004; 233:449-456
Harisinghani M, Saksena M, Hahn PF, et, al. Ferumoxtran-10 Enhanced MR Lymphangiography: Does Post Contrast Imaging Alone Suffice for Accurate Lymph Node Characterization? AJR (In press)

Detection of minimal disease in lymph nodes from prostate cancer spread

Mukesh G Harisinghani, MD

The long-term goal of this research is to investigate and correlate histologically the MR signal intensity patterns of ultrasmall superparamagnetic iron oxide (USPIO) in patients with adenocarcinoma of prostate.

Status:Completed
Type of trial:Prospective
imaging pathology correlation
Collaborators:S. Saini, MD
C. Tempany, MD
M. Schnall, MD, PhD
Funding:Internal
Publications:Harisinghani M, Saini S, Gregory Slater, Schnall MD, Rifkin MD. MR imaging of pelvic lymph nodes in primary pelvic carcinoma with ultrasmall superparamagnetic iron oxide (Combidex): preleminary observations. JMRI 1997; 7:161-163

Harisinghani M, Saini S, Slater GJ, Schnall MD, Rifkin MD. MR imaging of pelvic lymph nodes in primary pelvic Carcinoma with USPIO (Combidex). Academic Radiology 1998; 5(Suppl 1): S167-S169

Harisinghani M, Saini S, Weissleder R, Hahn P,Yantiss R, Tempany C, Wood B, Mueller P R. MR Lymphangiography Using Ultrasmall Superparamagnetic Iron Oxide (Combidex) In Patients With Primary Abdominal And Pelvic Malignancies: Radiographic-pathologic Correlation. AJR 1999; 172:1347-1351

Phase 1/2 trial of a synthetic graft copolymer

Ralph Weissleder, MD, PhD

The goal of this trial was to test the safety and efficacy of a synthetic graft copolymer for blood pool imaging.

Status:Completed
Type of trial:Prospective
Collaborators:R. Callahan PhD
A. Fischman, MD, PhD
Funding:Internal
Publications:Callahan, R. J., A. Bogdanov, Jr., et al. (1998). "Preclinical evaluation and phase I clinical trial of a 99mTc-labeled synthetic polymer used in blood pool imaging." Am J Roentgenol 171(1): 137-43.