Overview
On this page we present an overview of recent research projects of the Clinical Imaging Program at the Center for Molecular Imaging Research:
Ongoing clinical projects
Angiogenesis imaging in primary breast cancer
Alex R. Guimaraes, MD, PhD; Mukesh G Harisinghani, MD; Ralph Weissleder, MD, PhD
The overall goal of this proposal is to correlate signal intensity changes in primary breast cancer following nanoparticle administration with distribution of microvessel density.
| Status: | Open for enrollment |
| Type of trial: | Prospective imaging, pathology correlation |
| Collaborators: | Alphonse Taghian, MD,PhD Michele Gadd, MD |
| Funding: | MGH internally funded |
| Publications: | NA (ongoing trial) |
Imaging microvasculature in type 1 diabetes
Mukesh G Harisinghani, MD; Alex R. Guimaraes, MD, PhD; Ralph Weissleder, MD, PhD; Umar Mahmood MD, PhD
The overall aim of this component of the program is to explore the ability of MRI scans using MIONs to detect vascular changes associated with insulitis in patients with Type 1 diabetes.
| Status: | Ongoing |
| Type of trial: | Clinical |
| Collaborators: | Christophe Benoist, MD Richard Jackson, MD Diane Mathis, PhD |
| Funding: | NIAID PPG |
| Publications: | NA (ongoing trial) |
Clinical trials in planning
F-18 NaF PET for Detection of Bone Metastases in Men with Prostate Cancer
Ralph Weissleder, MD, PhD; Mukesh G Harisinghani, MD
The overall goal of this proposal is to improve the staging of advanced prostate cancer by detecting the presence of bony metastases using a non-invasive technique.
| Status: | Not open yet |
| Type of trial: | Clinical |
| Collaborators: | Matthew R Smith,MD, PhD |
| Funding: | NCI |
| Publications: | NA (ongoing trial) |
Preoperative staging of pancreatic cancer
Ralph Weissleder, MD, PhD; Mukesh G Harisinghani, MD
To improve the pre-operative staging of potentially resectable pancreatic cancers by detecting the presence of lymph node metastases using a non-invasive technique.
| Status: | Not open yet |
| Type of trial: | Clinical |
| Collaborators: | Andrew L Warshaw,MD |
| Funding: | NCI GI-spore program |
| Publications: | NA |
Completed clinical trials
Nodal staging in breast cancer
Mukesh Harisinghani, MD
The overall goal of this proposal is to extend the validated and novel approach to detecting cancer in lymph nodes of patients with breast cancer.
| Status: | Open for enrollment |
| Type of trial: | Prospective imaging, histopathology correlation |
| Collaborators: | Alphonse Taghian, MD,PhD Daniel B Kopans, MD Michele Gadd, MD Elizabeth Rafferty, MD Alex R. Guimaraes, MD, PhD |
| Funding: | Advanced Magnetics Inc., Cambridge / Breast Cancer Research Foundation |
| Publications: | NA (ongoing trial) |
Detection of minimal disease in lymph nodes from prostate cancer spread
Mukesh G Harisinghani, MD
The long-term goal of this research is to investigate and correlate histologically the MR signal intensity patterns of ultrasmall superparamagnetic iron oxide (USPIO) in patients with adenocarcinoma of prostate.
| Status: | Completed |
| Type of trial: | Prospective imaging pathology correlation |
| Collaborators: | Scott W McDougal, MD Shahin Tabatabei, MD Donald Kaufman, MD Anthony L Zietman, MD Jelle Berentz, MD |
| Funding: | RSNA Seed Grant |
| Publications: | Harisinghani M, Weissleder R. Sensitive, Noninvasive Detection of Lymph Node Metastases. PLoS Med 2004; 1:e66. |
Detection of minimal nodal disease in patients with primary genitourinary malignancies (renal, testicular, bladder, penis)
Mukesh G Harisinghani, MD
The long-term goal of this research is to investigate and correlate histologically the MR signal intensity patterns of ultrasmall superparamagnetic iron oxide (USPIO) in patients with adenocarcinoma of prostate.
| Status: | Completed |
| Type of trial: | Prospective imaging pathology correlation |
| Collaborators: | Scott W McDougal, MD Shahin Tabatabei, MD Donald Kaufman, MD Anthony L Zietman, MD Jelle Berentz, MD |
| Funding: | Advanced Magnetics Inc. |
| Publications: | Harisinghani, M. G., Barentsz, J., Hahn, P. F., Deserno, W. M., Tabatabaei, S., van de Kaa, C. H., de la Rosette, J., and Weissleder, R. Noninvasive detection of clinically occult lymph-node metastases in prostate cancer. N Engl J Med, 348: 2491-9, 2003. |
| Deserno W, Harisinghani M, Taupitz M, Jager G, Witjes JA, Mulders PF, Hulsbergen CA, Kaufman D, Barentsz J. Urinary bladder cancer: preoperative nodal staging with ferumoxtran-10 enhanced MR imaging. Radiology 2004; 233:449-456 | |
| Harisinghani M, Saksena M, Hahn PF, et, al. Ferumoxtran-10 Enhanced MR Lymphangiography: Does Post Contrast Imaging Alone Suffice for Accurate Lymph Node Characterization? AJR (In press) |
Detection of minimal disease in lymph nodes from prostate cancer spread
Mukesh G Harisinghani, MD
The long-term goal of this research is to investigate and correlate histologically the MR signal intensity patterns of ultrasmall superparamagnetic iron oxide (USPIO) in patients with adenocarcinoma of prostate.
| Status: | Completed |
| Type of trial: | Prospective imaging pathology correlation |
| Collaborators: | S. Saini, MD C. Tempany, MD M. Schnall, MD, PhD |
| Funding: | Internal |
| Publications: | Harisinghani M, Saini S, Gregory Slater, Schnall MD, Rifkin MD. MR imaging of pelvic lymph nodes in primary pelvic carcinoma with ultrasmall
superparamagnetic iron oxide (Combidex): preleminary observations. JMRI 1997; 7:161-163 Harisinghani M, Saini S, Slater GJ, Schnall MD, Rifkin MD. MR imaging of pelvic lymph nodes in primary pelvic Carcinoma with USPIO (Combidex). Academic Radiology 1998; 5(Suppl 1): S167-S169 Harisinghani M, Saini S, Weissleder R, Hahn P,Yantiss R, Tempany C, Wood B, Mueller P R. MR Lymphangiography Using Ultrasmall Superparamagnetic Iron Oxide (Combidex) In Patients With Primary Abdominal And Pelvic Malignancies: Radiographic-pathologic Correlation. AJR 1999; 172:1347-1351 |
Phase 1/2 trial of a synthetic graft copolymer
Ralph Weissleder, MD, PhD
The goal of this trial was to test the safety and efficacy of a synthetic graft copolymer for blood pool imaging.
| Status: | Completed |
| Type of trial: | Prospective |
| Collaborators: | R. Callahan PhD A. Fischman, MD, PhD |
| Funding: | Internal |
| Publications: | Callahan, R. J., A. Bogdanov, Jr., et al. (1998). "Preclinical evaluation and phase I clinical trial of a 99mTc-labeled synthetic polymer used in blood pool imaging." Am J Roentgenol 171(1): 137-43. |